GSM351746[Accession] - GEO DataSets

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Items: 4

Select item 2000140111.

Expression data from myeloma cell lines treated with 500 nM pristimerin or DMSO vehicle alone for 4 hours

(Submitter supplied) As multiple myeloma tumors universally dysregulate cyclin D genes we conducted high-throughput chemical library screens for compounds that induce suppression of cyclin D2. The top-ranked compound was a natural triterpenoid, pristimerin. We used gene expression microarray studies to identify co-regulated pristimerin-response genes and to deduce the compound’s direct molecular target(s), utilizing pattern-matching algorithms available at the Connectivity Map (Cmap). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5279
Platform:: GPL570
4 Samples

Download data: CEL

Series

Accession:: GSE14011

ID:: 200014011

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 52792.

Pristimerin effect on myeloma cell lines

Analysis of H929 and U266 myeloma cells treated with the natural triterpenoid pristimerin. Multiple myeloma tumors exhibit dysregulated cyclin D expression. Pristimerin identified from a chemical library screen for compounds that induce suppression of transcription from the cyclin D2 promoter.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 2 cell line sets

Platform:: GPL570
Series:: GSE14011
4 Samples

Download data: CEL

DataSet

Accession:: GDS5279

ID:: 5279

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000005703.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...