GSM3326517[Accession] - GEO DataSets

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Items: 4

Select item 2001183901.

Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL16791 GPL9052
1539 Samples

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Accession:: GSE118390

ID:: 200118390

PubMed Full text in PMC Similar studies

Select item 2001183892.

Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq [RNA-Seq]

(Submitter supplied) Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by extensive intratumoral heterogeneity. To investigate the underlying biology, we conduct single-cell RNA- sequencing (scRNA-seq) of >1500 cells from six primary TNBC. Intercellular heterogeneity of gene expression programs within each tumor was variable and largely correlated with clonality of inferred genomic copy number changes, suggesting that genotype drives the gene expression phenotype of individual subpopulations. more...