GSM3223426[Accession] - GEO DataSets

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Items: 3

Select item 2000867951.

6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda

(Submitter supplied) A long-standing question in the field of embryogenesis is how the zygotic genome is precisely activated by maternal factors, allowing normal early embryonic development. We have previously shown that N6-methyladenine (6mA) DNA modification is highly dynamic in early Drosophila embryos and forms an epigenetic mark. However, little is known about how 6mA-formed epigenetic information is decoded. Here we report that the Fox-family protein Jumu binds 6mA-marked DNA and acts as a maternal factor to regulate the maternal-to-zygotic transition. more...

Organism:: Drosophila melanogaster

Type:: Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other