GSM2230698[Accession] - GEO DataSets

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Items: 4

Select item 2000842811.

Integrative "-omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array; Methylation profiling by genome tiling array

Platforms:: GPL16284 GPL18402 GPL17996
53 Samples

Download data: CEL, PAIR, TXT

Series

Accession:: GSE84281

ID:: 200084281

Select item 2000842762.

Integrative "-omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis (MeDIP)

(Submitter supplied) Cyclosporine A (CsA), is an endecapeptide with strong immunosuppressant activities and has contributed significantly towards clinical progress in organ transplantation. Furthermore, it has various toxic effects in the kidney and especially in the liver where it may induce cholestasis. The CsA drug-induced cholestasis (DIC) pathway includes important genes involved in the uptake, synthesis, conjugation and secretion of bile acids, which can be verified also in hepatic models in vitro. more...