GSM1502851[Accession] - GEO DataSets

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Items: 4

Select item 2000609541.

Expression profiling and Pol II occupancy of HeLa cell line treated with CDK9 inhibitor

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11154 GPL18756
23 Samples

Download data: BED, BEDGRAPH, CEL

Series

Accession:: GSE60954

ID:: 200060954

Analyze with GEO2R

Select item 2000609522.

Expression profiling of HeLa cell line treated with CDK9 inhibitor

(Submitter supplied) CDK9 is the kinase subunit of P-TEFb that enables RNA polymerase (Pol) II to transit from promoter-proximal pausing to productive elongation. Although considerable interest exists in CDK9 as a therapeutic target, little progress has been made due to the lack of highly selective inhibitors. Here, we describe the development of i-CDK9 as such an inhibitor that potently suppresses CDK9 phosphorylation of substrates and causes genome-wide Pol II pausing. more...