GSM1104585[Accession] - GEO DataSets

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Items: 4

Select item 2000454571.

A Switch Between Topological Domains Underlies HoxD Genes Collinearity in Mouse Limbs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by genome tiling array; Other; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL9185 GPL14183 GPL9250
29 Samples

Download data: BEDGRAPH, CEL

Series

Accession:: GSE45457

ID:: 200045457

PubMed Similar studies

Select item 2000454552.

A Switch Between Topological Domains Underlies HoxD Genes Collinearity in Mouse Limbs (4C-Seq)

(Submitter supplied) During limb development, Hoxd genes are transcribed in two waves: Early on, when the arm and forearm are specified and subsequently, when digits form. While the latter phase is controlled by enhancers centromeric to the HoxD cluster, we show here that the early phase requires enhancers located in the opposite telomeric gene desert. The transition between the two types of regulations involves a functional switch between two distinct topological domains, as reflected by a subset of genes mapping centrally into the cluster, which initially interact with the telomeric domain and subsequently shift to establish new contacts on the opposite side. more...