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Items: 4

1.

Transcription factor Bcl11b controls identity and function of mature innate lymphoid cells type II

(Submitter supplied) Type-2 innate lymphoid cells (ILC2s) promote anti-helminth responses and contribute to allergies. Though Bcl11b has been previously considered a T-lineage identity transcription factor (TF) that restrains the innate-cell genetic programs, we report here that Bcl11b is highly expressed in mature ILC2s and acts upstream of the key ILC2 TFs Gfi1, Gata-3, and of IL-33 receptor IL1rl1 (T1ST2). Additionally, Bcl11b-/- ILC2s de-repressed Rorγt, Ahr and IL-23 receptor, normally expressed in type-3 ILCs (ILC3s). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
2 Samples
Download data: TXT
Series
Accession:
GSE67437
ID:
200067437
2.

Illumina HiSeq 2500 (Mus musculus)

Platform
Accession:
GPL17021
ID:
100017021
3.

TMX-Bcl11bF/F Cre-ERT2

Organism:
Mus musculus
Source name:
TMX-Bcl11bF/F Cre-ERT2
Platform:
GPL17021
Series:
GSE67437
Download data
Sample
Accession:
GSM1646800
ID:
301646800
4.

TMX-Wild type control

Organism:
Mus musculus
Source name:
TMX-Wild type control
Platform:
GPL17021
Series:
GSE67437
Download data
Sample
Accession:
GSM1646799
ID:
301646799
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Supplemental Content

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