GSE216294[Accession] - GEO DataSets - NCBI

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Select item 2002162941.

A TDP-43 acetylation-mimic mutation that disrupts RNA-binding drives FTLD-like neurodegeneration in a mouse model of sporadic TDP-43 proteinopathy

(Submitter supplied) TDP-43 proteinopathies including frontotemporal lobar dementia (FTLD) and amyotrophic lateral sclerosis (ALS) are devastating neurodegenerative disorders characterized by aggregation and mislocalization of the nucleic-acid binding protein TDP-43 and subsequent neuronal dysfunction. Here, we developed an endogenous model of sporadic TDP-43 proteinopathy based on the principle that disease-associated TDP-43 acetylation at lysine 145 (K145) alters TDP-43 conformation, impairs its RNA-binding capacity, and induces downstream mis-regulation of target genes. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
20 Samples

Download data: TXT

Series

Accession:: GSE216294

ID:: 200216294

PubMed Full text in PMC Similar studies

Select item 1000242472.

Illumina NovaSeq 6000 (Mus musculus)

Organism:: Mus musculus

14170 Series
692715 Samples

Platform

Accession:: GPL24247

ID:: 100024247

Select item 3066661633.

Hippocampus_TDP43-KQ_Male_rep2

Organism:: Mus musculus

Source name:: Hippocampus

Platform:: GPL24247
Series:: GSE216294

Sample

Accession:: GSM6666163

ID:: 306666163

SRA Run Selector

Select item 3066661624.

Hippocampus_TDP43-KQ_Male_rep1

Organism:: Mus musculus

Source name:: Hippocampus

Platform:: GPL24247
Series:: GSE216294

Sample

Accession:: GSM6666162

ID:: 306666162

SRA Run Selector

Select item 3066661615.

Hippocampus_TDP43-WT_Male_rep1

Organism:: Mus musculus

Source name:: Hippocampus

Platform:: GPL24247
Series:: GSE216294

Sample

Accession:: GSM6666161

ID:: 306666161

SRA Run Selector

Select item 3066661606.

Hippocampus_TDP43-KQ_Female_rep3

Organism:: Mus musculus

Source name:: Hippocampus

Platform:: GPL24247
Series:: GSE216294

Sample

Accession:: GSM6666160

ID:: 306666160

SRA Run Selector

Select item 3066661597.

Hippocampus_TDP43-KQ_Female_rep2

Organism:: Mus musculus

Source name:: Hippocampus

Platform:: GPL24247
Series:: GSE216294

Sample

Accession:: GSM6666159

ID:: 306666159

SRA Run Selector

Select item 3066661588.

Hippocampus_TDP43-KQ_Female_rep1

Organism:: Mus musculus

Source name:: Hippocampus

Platform:: GPL24247
Series:: GSE216294

Sample

Accession:: GSM6666158

ID:: 306666158

SRA Run Selector

Select item 3066661579.

Hippocampus_TDP43-WT_Female_rep3

Organism:: Mus musculus

Source name:: Hippocampus

Platform:: GPL24247
Series:: GSE216294

Sample

Accession:: GSM6666157

ID:: 306666157

SRA Run Selector

Select item 30666615610.

Hippocampus_TDP43-WT_Female_rep2

Organism:: Mus musculus

Source name:: Hippocampus

Platform:: GPL24247
Series:: GSE216294

Sample

Accession:: GSM6666156

ID:: 306666156

SRA Run Selector

Select item 30666615511.

Hippocampus_TDP43-WT_Female_rep1

Organism:: Mus musculus

Source name:: Hippocampus

Platform:: GPL24247
Series:: GSE216294

Sample

Accession:: GSM6666155

ID:: 306666155

SRA Run Selector

Select item 30666615412.

Cortex_TDP43-KQ_Male_rep3

Organism:: Mus musculus

Source name:: Cortex

Platform:: GPL24247
Series:: GSE216294

Sample

Accession:: GSM6666154

ID:: 306666154

SRA Run Selector

Select item 30666615313.

Cortex_TDP43-KQ_Male_rep2

Organism:: Mus musculus

Source name:: Cortex

Platform:: GPL24247
Series:: GSE216294

Sample

Accession:: GSM6666153

ID:: 306666153

SRA Run Selector

Select item 30666615214.

Cortex_TDP43-KQ_Male_rep1

Organism:: Mus musculus

Source name:: Cortex

Platform:: GPL24247
Series:: GSE216294

Sample

Accession:: GSM6666152

ID:: 306666152

SRA Run Selector

Select item 30666615115.

Cortex_TDP43-WT_Male_rep2

Organism:: Mus musculus

Source name:: Cortex

Platform:: GPL24247
Series:: GSE216294

Sample

Accession:: GSM6666151

ID:: 306666151

SRA Run Selector

Select item 30666615016.

Cortex_TDP43-WT_Male_rep1

Organism:: Mus musculus

Source name:: Cortex

Platform:: GPL24247
Series:: GSE216294

Sample

Accession:: GSM6666150

ID:: 306666150

SRA Run Selector

Select item 30666614917.

Cortex_TDP43-KQ_Female_rep3

Organism:: Mus musculus

Source name:: Cortex

Platform:: GPL24247
Series:: GSE216294

Sample

Accession:: GSM6666149

ID:: 306666149

SRA Run Selector

Select item 30666614818.

Cortex_TDP43-KQ_Female_rep2

Organism:: Mus musculus

Source name:: Cortex

Platform:: GPL24247
Series:: GSE216294

Sample

Accession:: GSM6666148

ID:: 306666148

SRA Run Selector

Select item 30666614719.

Cortex_TDP43-KQ_Female_rep1

Organism:: Mus musculus

Source name:: Cortex

Platform:: GPL24247
Series:: GSE216294

Sample

Accession:: GSM6666147

ID:: 306666147

SRA Run Selector

Select item 30666614620.

Cortex_TDP43-WT_Female_rep3

Organism:: Mus musculus

Source name:: Cortex

Platform:: GPL24247
Series:: GSE216294

Sample

Accession:: GSM6666146

ID:: 306666146

SRA Run Selector

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GSE216294[Accession] (22)
GEO DataSets
Coryphantha chlorantha psbA (psbA) gene, partial cds; and psbA-trnH intergenic s...
Coryphantha chlorantha psbA (psbA) gene, partial cds; and psbA-trnH intergenic spacer, partial sequence; chloroplast
gi|426204964|gb|KC196848.1|

Nucleotide
TRAF2 and NCK-interacting protein kinase isoform X5 [Canis lupus familiaris]
TRAF2 and NCK-interacting protein kinase isoform X5 [Canis lupus familiaris]
gi|1953056370|ref|XP_038439820.1|

Protein
fv95c09.y1 Zebrafish SJD adult male II Danio rerio cDNA clone IMAGE:5544952 5', ...
fv95c09.y1 Zebrafish SJD adult male II Danio rerio cDNA clone IMAGE:5544952 5', mRNA sequence
gi|17516921|gnl|dbEST|10536309|gb|B 63.1|

Nucleotide
ft46f02.y1 Gong zebrafish ovary Danio rerio cDNA clone IMAGE:5153787 5', mRNA se...
ft46f02.y1 Gong zebrafish ovary Danio rerio cDNA clone IMAGE:5153787 5', mRNA sequence
gi|15684052|gnl|dbEST|9567395|gb|BI 7.1|

Nucleotide

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