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Items: 7

1.

Small molecule screen identifies de novo nucleotide synthesis as a vulnerability of cells lacking SIRT3

(Submitter supplied) Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase downregulated in aging and age-associated diseases such as cancer and neurodegeneration, and high fat diet (HFD)-induced metabolic disorders. Thus, we performed a small molecule screen and identified an unexpected metabolic vulnerability associated with SIRT3 loss.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
5 Samples
Download data: TXT
Series
Accession:
GSE109279
ID:
200109279

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina NextSeq 500 (Mus musculus)

Organism:
Mus musculus
10286 Series
295783 Samples
Download data
Platform
Accession:
GPL19057
ID:
100019057

3.

SIRT3 KO MEF rep 2

Organism:
Mus musculus
Source name:
mouse embryonic fibroblasts
Platform:
GPL19057
Series:
GSE109279
Download data
Sample
Accession:
GSM2936415
ID:
302936415

SRA Run Selector

4.

SIRT3 KO MEF rep 1

Organism:
Mus musculus
Source name:
mouse embryonic fibroblasts
Platform:
GPL19057
Series:
GSE109279
Download data
Sample
Accession:
GSM2936414
ID:
302936414

SRA Run Selector

5.

SIRT3 WT MEF rep 3

Organism:
Mus musculus
Source name:
mouse embryonic fibroblasts
Platform:
GPL19057
Series:
GSE109279
Download data
Sample
Accession:
GSM2936413
ID:
302936413

SRA Run Selector

6.

SIRT3 WT MEF rep 2

Organism:
Mus musculus
Source name:
mouse embryonic fibroblasts
Platform:
GPL19057
Series:
GSE109279
Download data
Sample
Accession:
GSM2936412
ID:
302936412

SRA Run Selector

7.

SIRT3 WT MEF rep 1

Organism:
Mus musculus
Source name:
mouse embryonic fibroblasts
Platform:
GPL19057
Series:
GSE109279
Download data
Sample
Accession:
GSM2936411
ID:
302936411

SRA Run Selector

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db=gds|term=GSE109279[Accession]|query=11|qty=2|blobid=MCID_6734e293b31eac71f53d3918|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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