GEO DataSets

(Submitter supplied) ERG and FLI1 are important regulators of angiogenesis, but their role in lymphatic vasculature is less known. The goal of this study was to determine the role of ERG and FLI1 in postnatal lymphangiogenesis and their involvement in SSc lymphatic system defects. IF were used to detect ERG and FLI1 in SSc and healthy controls (HC) skin biopsies. Human lymphatic endothelial cells (LECs) were used in cell culture experiments. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17930

12 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:

GPL24676 GPL17930

61 Samples

Download data: CEL, TXT

(Submitter supplied) Frontotemporal dementia (FTD) is an incurable group of early-onset dementias that can be caused by deposition of hyperphosphorylated tau in patient brains. However, the mechanisms leading to neurodegeneration remain largely unknown. Here, we combined single-cell analyses of FTD patient brains with a stem cell culture and transplantation model of FTD. We identified disease phenotypes in FTD neurons carrying the MAPT-N279K mutation, which were related to oxidative stress, oxidative phosphorylation and neuroinflammation with an upregulation of the inflammation-associated protein osteopontin (OPN). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17930

18 Samples

Download data: CEL

(Submitter supplied) E7386 inhibits interaction between B-catenin and CREB-binding protein (CBP), which drives oncogenic gene expression and aggressive cancer phenotypes in oral squamous cell carcinomas (OSCC). We use microarrays to profile the effects of E7386 treatment on gene expression of HSC3 human OSCC cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17930

6 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

synthetic construct; Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array; Expression profiling by high throughput sequencing

Platforms:

GPL18573 GPL19117 GPL17930

28 Samples

Download data: CEL

(Submitter supplied) We combine state-of-the-art data acquisition platforms and bioinformatics tools to devise PAMAF, a workflow that simultaneously examines twelve omics modalities, i.e., protein abundance from whole-cells, nucleus, exosomes, secretome and membrane; N-glycosylation, phosphorylation; metabolites; mRNA, miRNA; and, in parallel, single-cell transcriptomes. Here we apply PAMAF in an established in vitro model of TGFβ-induced epithelial to mesenchymal transition (EMT) to quantify >61,000 molecules from 12 omics and 10 timepoints over 12 days. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17930

10 Samples

Download data: CEL

(Submitter supplied) Glioblastoma is a high-grade glial neoplasm with a patient survival of 12-18 months. Therefore, there is an urgent need for identification of novel therapeutic targets. RAB38 is a member of a family of small GTPase proteins and has been implicated in regulating cell proliferation and survival in tumors. The role of RAB38 in glioblastoma is unexplored. Here, we used human glioblastoma cell lines to test the hypothesis that RAB38 regulates glioblastoma growth. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17930

4 Samples

Download data: CEL

(Submitter supplied) We described the metabolic alterations in glioblastoma model systems elicited by AURKA inhibition. By utilizing proteomic and transcriptomic analyses coupled with untargeted polar and nonpolar metabolite analysis by LC/MC, we found that AURKA inhibition leads to a profound reprogramming of tumor metabolism, which suppresses c-Myc protein levels and increases pro-survival PGC1α which in concert mediate a suppression of glycolysis and a concomitant activation of oxidative phosphorylation (OXPHOS) that is fueled by enhanced fatty acid oxidation (FAO). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17930

4 Samples

Download data: CEL

(Submitter supplied) Gene expression of chronically or acutely Crizotinib treated glioblastoma cells vs vehicle controls

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17930

4 Samples

Download data: CEL

(Submitter supplied) Histone modifications, largely regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs) have been recognized as major regulatory mechanisms governing human diseases including cancer. Despite significant effort and recent advances, the mechanism by which the p300 transcriptional coactivator mediates tumorigenesis remains unclear. Here, we use a genetic and chemical approach to identify the Microphthalmia-associated transcription factor (MITF) as a critical downstream target of p300 driving human melanoma growth. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17930

8 Samples

Download data: CEL

(Submitter supplied) Skeletal muscle wasting is a devastating consequence of cancer that may be responsible for nearly 30% of cancer-related deaths. In addition to muscle atrophy, we have identified significant muscle fiber damage and replacement of muscle with fibrotic tissue in rectus abdominis muscle biopsies from cachectic pancreatic ductal adenocarcinoma (PDAC) patients that associates with poor survival. Transcriptional profiling of muscle harvested from these same patients supported these findings by identifying gene clusters related to wounding, inflammation and cellular response to TGF-B upregulated in cachectic PDAC patients compared with non-cancer controls. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17930

46 Samples

Download data: CEL

(Submitter supplied) We performed microarray analysis in order to evaluate the combination effect of the mitochondrial matrix chaperone inhibitor gamitrinib-triphenylphosphonium (G-TPP) and Liver X receptor agonist LXR623 on gene expression in stem cell like glioma cells (NCH644).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17930

8 Samples

Download data: CEL

(Submitter supplied) We performed microarray analysis in order to evaluate the effect of ONC201 on gene expression in glioma cells (U87).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17930

2 Samples

Download data: CEL

(Submitter supplied) Microarray analysis was performed to compare gene expression between stem cell like glioma cells and their differentiated cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17930

4 Samples

Download data: CEL

(Submitter supplied) Low dose of HDAC inhibitor (Panobinostat) treatment causes U87 cells to become resistant to the drug. Gene expression of the resistant cell line is altered comparing to the vehicle control.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17930

2 Samples

Download data: CEL

(Submitter supplied) Here, we generated and differentiated a human induced pluripotent stem cell line with an ACTA2eGFP reporter towards a smooth muscle-like cell that can be purified and expresses characteristic markers of smooth muscle cells. We performed microarray analysis of day 30 ACTA2eGFP+ and ACTA2eGFP- sorted populations, and the transcriptomic profile of the ACTA2eGFP+ cells is reminiscent of an immature or a synthetic smooth muscle cell phenotype.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17930

6 Samples

Download data: CEL

(Submitter supplied) The goal of this study was to determine if loss of STK25 or gain of miR-24-3p resulted in YAP/TAZ activation.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17930

9 Samples

Download data: CEL

(Submitter supplied) The goal of this study was to identify an active YAP/TAZ signature in the hTERT-RPE-1 cell line.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17930

8 Samples

Download data: CEL

(Submitter supplied) We performed micro array analysis in order to evaluate the effect of LXR623 on gene expression in glioma cancer cells (U87).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17930

2 Samples

Download data: CEL

(Submitter supplied) We performed micro array analysis in order to evaluate the effect of LXR623 on gene expression in colon cancer cells (HCT116).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17930

2 Samples

Download data: CEL