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Items: 1 to 20 of 56

1.

Ribosomes guide pachytene piRNA formation on long intergenic piRNA precursors

(Submitter supplied) PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs essential for fertility. In adult mouse testes, most piRNAs are derived from long single-stranded RNAs lacking annotated open reading frames (ORFs). The mechanisms underlying how piRNA sequences are defined during the cleavages of piRNA precursors remain elusive. Here, we show that 80S ribosomes translate the 5′-proximal short ORFs (uORFs) of piRNA precursors. more...
Organism:
Mus musculus; Anolis carolinensis
Type:
Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL13112 GPL15001
61 Samples
Download data: BED2, TXT
Series
Accession:
GSE65786
ID:
200065786
2.

Evidence against tetrapod-wide digit identities and for a limited frame shift in bird wings

(Submitter supplied) In crown group tetrapods, individual digits are homologized in relation to a pentadactyl ground plan. However, testing hypotheses of digit homology is challenging because it is unclear whether digits develop with distinct and conserved gene regulatory states. Here we show dramatic evolutionary dynamism in the gene expression profiles of digits, challenging the notion that five digit identities are conserved across amniotes. more...
Organism:
Anolis carolinensis; Alligator mississippiensis; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL13112 GPL24412 GPL15001
59 Samples
Download data: TXT
Series
Accession:
GSE108337
ID:
200108337
3.

PITX1 Promotes Chondrogenesis and Myogenesis in Mouse Hindlimbs Through Conserved Regulatory Targets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Anolis carolinensis; Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL19057 GPL15001
21 Samples
Download data: BW
Series
Accession:
GSE104460
ID:
200104460
4.

PITX1 Promotes Chondrogenesis and Myogenesis in Mouse Hindlimbs Through Conserved Regulatory Targets [ChIP-Seq]

(Submitter supplied) The PITX1 transcription factor is expressed during hindlimb development, where it plays a critical role in directing hindlimb growth and the specification of hindlimb morphology. While it is known that PITX1 regulates hindlimb formation, in part, through activation of the Tbx4 gene, other transcriptional targets remain to be elucidated. We have used a combination of ChIP-seq and RNA-seq to investigate enhancer regions and target genes that are directly regulated by PITX1 in embryonic mouse hindlimbs. more...
Organism:
Anolis carolinensis
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL15001
3 Samples
Download data: BW
Series
Accession:
GSE104457
ID:
200104457
5.

BioProject PRJNA381064: Convergent origination of a Drosophila-like dosage compensation mechanism in a reptile lineage (Allelic Gene Expression in Anolis carolinensis, bulk tissue RNA-seq)

(Submitter supplied) In order to rule out the presence of imprinted X inactivation in A. carolinensis females we generated RNA-seq data from brain, heart, kidney, liver, ovary and genome sequence data from kidney.
Organism:
Anolis carolinensis
Type:
Expression profiling by high throughput sequencing; Other
Platforms:
GPL23252 GPL15001
15 Samples
Download data: VCF
Series
Accession:
GSE107602
ID:
200107602
6.

BioProject PRJNA381064: Convergent origination of a Drosophila-like dosage compensation mechanism in a reptile lineage (Allelic Gene Expression in Anolis carolinensis, single-cell RNA-seq)

(Submitter supplied) In order to rule out the presence of random X inactivation in A. carolinensis females we generated scRNA-Seq from liver cells and genome sequence data from liver.
Organism:
Anolis carolinensis
Type:
Genome variation profiling by high throughput sequencing
Platforms:
GPL15001 GPL23678
7 Samples
Download data: VCF
Series
Accession:
GSE100976
ID:
200100976
7.

Identifying active cis-regulatory elements during the development of the limbs and external genitalia in the mouse and lizard.

(Submitter supplied) The morphologies of the amniote phallus and limbs differ dramatically, but these structures share signaling pathways and patterns of gene expression in early development. Thus far, the extent to which genital and limb transcriptional networks share cis-regulatory elements has remained unexplored. Using chromatin immunoprecipitation with an antibody against the histone modification mark H3K27ac followed by Illumina high-throughput sequencing, we identify thousands of active enhancers in developing limbs, genital tubercle, and additional embryonic tissues of the mouse and green anole lizard (Anolis carolinensis). more...
Organism:
Mus musculus; Anolis carolinensis
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL13112 GPL15001
21 Samples
Download data: BED, BW
Series
Accession:
GSE64055
ID:
200064055
8.

A relative shift in cloacal location repositions external genitalia in amniote evolution

(Submitter supplied) Comparative RNA-seq profiling of mouse and anole lizard developing limbs and external genitalia, to assess evolutionary and develomental relationships, between the two tissue types based on transcriptomic data
Organism:
Anolis carolinensis; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL13112 GPL15001
24 Samples
Download data: TXT
Series
Accession:
GSE60373
ID:
200060373
9.

The evolutionary landscape of alternative splicing in vertebrate species

(Submitter supplied) How species with similar repertoires of protein coding genes differ so dramatically at the phenotypic level is poorly understood. From comparing the transcriptomes of multiple organs from vertebrate species spanning ~350 million years of evolution, we observe significant differences in alternative splicing complexity between the main vertebrate lineages, with the highest complexity in the primate lineage. more...
Organism:
Anolis carolinensis; Xenopus tropicalis; Gallus gallus; Mus musculus; Tetraodon nigroviridis
Type:
Expression profiling by high throughput sequencing
5 related Platforms
21 Samples
Download data: BW, TXT
Series
Accession:
GSE41338
ID:
200041338
10.

The transcriptome of embryos of the green anole, Anolis carolinensis, at 28 and 38 somite pair stages

(Submitter supplied) Anolis carolinensis embryos were collected 0-1 days post egg laying, and total RNA was extracted for RNA-Seq analysis (Illumina Hi-Seq2000). Transcriptome sequence from these stages in the green anole, equivalent to mouse 9.5-10.5 dpc embryos, will help to improve gene annotations in A. carolinensis and provide expression level information for key organogenesis and patterning processes.
Organism:
Anolis carolinensis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL15001
2 Samples
Download data: TXT
Series
Accession:
GSE34415
ID:
200034415
11.

Illumina HiSeq 2000 (Anolis carolinensis)

Organism:
Anolis carolinensis
10 Series
45 Samples
Download data
Platform
Accession:
GPL15001
ID:
100015001
12.

Riboseq.lizard.testis.wt.adult.rep1

Organism:
Anolis carolinensis
Source name:
testis
Platform:
GPL15001
Series:
GSE65786
Download data: TXT
Sample
Accession:
GSM4160724
ID:
304160724
13.

Anolis forelimb D5 rep3

Organism:
Anolis carolinensis
Source name:
forelimb digit5
Platform:
GPL15001
Series:
GSE108337
Download data
Sample
Accession:
GSM2895546
ID:
302895546
14.

Anolis forelimb D5 rep2

Organism:
Anolis carolinensis
Source name:
forelimb digit5
Platform:
GPL15001
Series:
GSE108337
Download data
Sample
Accession:
GSM2895545
ID:
302895545
15.

Anolis forelimb D5 rep1

Organism:
Anolis carolinensis
Source name:
forelimb digit5
Platform:
GPL15001
Series:
GSE108337
Download data
Sample
Accession:
GSM2895544
ID:
302895544
16.

Anolis forelimb D4 rep3

Organism:
Anolis carolinensis
Source name:
forelimb digit4
Platform:
GPL15001
Series:
GSE108337
Download data
Sample
Accession:
GSM2895543
ID:
302895543
17.

Anolis forelimb D4 rep2

Organism:
Anolis carolinensis
Source name:
forelimb digit4
Platform:
GPL15001
Series:
GSE108337
Download data
Sample
Accession:
GSM2895542
ID:
302895542
18.

Anolis forelimb D4 rep1

Organism:
Anolis carolinensis
Source name:
forelimb digit4
Platform:
GPL15001
Series:
GSE108337
Download data
Sample
Accession:
GSM2895541
ID:
302895541
19.

Anolis forelimb D3 rep3

Organism:
Anolis carolinensis
Source name:
forelimb digit3
Platform:
GPL15001
Series:
GSE108337
Download data
Sample
Accession:
GSM2895540
ID:
302895540
20.

Anolis forelimb D3 rep2

Organism:
Anolis carolinensis
Source name:
forelimb digit3
Platform:
GPL15001
Series:
GSE108337
Download data
Sample
Accession:
GSM2895539
ID:
302895539
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