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Items: 1 to 20 of 22

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1.

JAML is a novel immunotherapy target for tissue-resident memory T cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
26 Samples
Download data
Series
Accession:
GSE185162
ID:
200185162

PubMed Full text in PMC Similar studies

2.

JAML is a novel immunotherapy target for tissue-resident memory T cells [scRNA-seq]

(Submitter supplied) Tumor-infiltrating CD8+ T cells express high levels of the co-stimulatory molecule JAML, which can be exploited for cancer immunotherapy.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
2 Samples
Download data: CSV, TXT
Series
Accession:
GSE185161
ID:
200185161

PubMed Full text in PMC Similar studies SRA Run Selector

3.

JAML is a novel immunotherapy target for tissue-resident memory T cells [bulk RNA-seq]

(Submitter supplied) Tumor-infiltrating CD8+ T cells express high levels of the co-stimulatory molecule JAML, which can be exploited for cancer immunotherapy.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
24 Samples
Download data: TXT
Series
Accession:
GSE185160
ID:
200185160

PubMed Full text in PMC Similar studies SRA Run Selector

4.

Intratumoral TFR cells curtail anti-PD-1 treatment efficacy

(Submitter supplied) Follicular regulatory T cells (TFR cells) and their functional role in cancer have been completely disregarded so far. Our data identify that as a critical oversight, as these cells account for a substantial proportion of tumor-infiltrating CD4+ T cells
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Other
Platform:
GPL24676
4 Samples
Download data: TXT
Series
Accession:
GSE145691
ID:
200145691

SRA Run Selector

5.

Immunomodulatory effects of PI3Kδ inhibition in murine and human solid tumors [mouse]

(Submitter supplied) Phosphoinositide 3-kinase δ (PI3Kδ) plays key roles in lymphocytes and inhibitors targeting this PI3K have been approved for hematological malignancies. While preclinical data in hematological and solid tumor models have demonstrated that PI3Kδ inhibitors (PI3Kδi) can induce anti-tumor immunity, the impact of PI3Kδi in human solid tumors remains unknown. Here, we assessed the effects of the PI3Kδi AMG319 in patients with early stage head and neck cancer in a neoadjuvant, double-blind and placebo-controlled randomised phase-II trial. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
9 Samples
Download data: TXT
Series
Accession:
GSE166149
ID:
200166149

PubMed Full text in PMC Similar studies SRA Run Selector

6.

Immunomodulatory effects of PI3Kδ inhibition in murine and human solid tumors [human]

(Submitter supplied) Phosphoinositide 3-kinase δ (PI3Kδ) plays key roles in lymphocytes and inhibitors targeting this PI3K have been approved for hematological malignancies. While preclinical data in hematological and solid tumor models have demonstrated that PI3Kδ inhibitors (PI3Kδi) can induce anti-tumor immunity, the impact of PI3Kδi in human solid tumors remains unknown. Here, we assessed the effects of the PI3Kδi AMG319 in patients with early stage head and neck cancer in a neoadjuvant, double-blind and placebo-controlled randomised phase-II trial. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
2297 Samples
Download data: TXT
Series
Accession:
GSE166148
ID:
200166148

PubMed Full text in PMC Similar studies SRA Run Selector

7.

Immunomodulatory effects of PI3Kδ inhibition in murine and human solid tumors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL16791 GPL24247
2306 Samples
Download data
Series
Accession:
GSE166150
ID:
200166150

PubMed Full text in PMC Similar studies

8.

Gene expression data from CD34+ BMMCs/PBMCs from MPN patients vs. healthy controls

(Submitter supplied) Philadelphia chromosome-negative myeloproliferative neoplasms (MPN) consist of primary myelofibrosis (PMF), polycythemia vera (PV), essential thrombocythemia (ET) and seconday myelofibrosis (SMF), comprising post-ET-MF(pET-MF) and post-PV-MF(pPV-MF). In this dataset, we compare the gene expression data of bone marrow or peripheral blood mononuclear cells (BMMCs/PBMCs) of CD34+ cells from MPN patients and healthy donors. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17586
36 Samples
Download data: CEL
Series
Accession:
GSE174060
ID:
200174060

PubMed Full text in PMC Similar studies Analyze with GEO2R

9.

Intratumoral TFR cells curtail anti-PD-1 treatment efficacy

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL24247 GPL16791 GPL24676
62 Samples
Download data
Series
Accession:
GSE132297
ID:
200132297

PubMed Full text in PMC Similar studies

10.

Intratumoral TFR cells curtail anti-PD-1 treatment efficacy [mouse]

(Submitter supplied) Follicular regulatory T cells (TFR cells) and their functional role in cancer have been completely disregarded so far. Our data identify that as a critical oversight, as these cells account for a substantial proportion of tumor-infiltrating CD4+ T cells
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
42 Samples
Download data: TXT
Series
Accession:
GSE132296
ID:
200132296

PubMed Full text in PMC Similar studies SRA Run Selector

11.

Intratumoral TFR cells curtail anti-PD-1 treatment efficacy [human]

(Submitter supplied) Follicular regulatory T cells (TFR cells) and their functional role in cancer have been completely disregarded so far. Our data identify that as a critical oversight, as these cells account for a substantial proportion of tumor-infiltrating CD4+ T cells
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL16791 GPL24676
20 Samples
Download data: TXT
Series
Accession:
GSE132295
ID:
200132295

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

12.

Imbalance of regulatory and cytotoxic SARS-CoV-2-reactive CD4+ T cells in COVID-19

(Submitter supplied) The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-CoV-2 infection remains unknown. Here, we present a large-scale single-cell transcriptomic analysis of viral antigen-reactive CD4+ T cells from 40 COVID-19 patients. In hospitalized patients compared to non-hospitalized patients, we found increased proportions of cytotoxic follicular helper (TFH) cells and cytotoxic T helper cells (CD4-CTLs) responding to SARS-CoV-2, and reduced proportion of SARS-CoV-2-reactive regulatory T cells (TREG). more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
78 Samples
Download data: TXT
Series
Accession:
GSE152522
ID:
200152522

PubMed Full text in PMC Similar studies SRA Run Selector

13.

Single-cell transcriptomic analysis of tissue resident memory T cells in human lung cancer [ATAC-Seq]

(Submitter supplied) High numbers of tissue-resident memory T (TRM) cells have been associated with better clinical outcomes in cancer patients. However, the molecular characteristics that drive their efficient immune response to tumors are poorly understood. Here, using single-cell and bulk transcriptomic analysis of purified populations of TRM and non-TRM cells we characterise these populations
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL16791 GPL24676
9 Samples
Download data: BW
Series
Accession:
GSE125858
ID:
200125858

PubMed Full text in PMC Similar studies SRA Run Selector

14.

Single-cell transcriptomic analysis of tissue resident memory T cells in human lung cancer.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Other; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL24676 GPL15520 GPL16791
1252 Samples
Download data
Series
Accession:
GSE111898
ID:
200111898

PubMed Full text in PMC Similar studies

15.

Single-cell transcriptomic analysis of tissue resident memory T cells in human lung cancer [TCR-seq]

(Submitter supplied) High numbers of tissue-resident memory T (TRM) cells have been associated with better clinical outcomes in cancer patients. However, the molecular characteristics that drive their efficient immune response to tumors are poorly understood. Here, using single-cell and bulk transcriptomic analysis of purified populations of TRM and non-TRM cells we characterise these populations
Organism:
Homo sapiens
Type:
Other
Platform:
GPL15520
20 Samples
Download data: TXT
Series
Accession:
GSE111897
ID:
200111897

PubMed Full text in PMC Similar studies SRA Run Selector

16.

Single-cell transcriptomic analysis of tissue resident memory T cells in human lung cancer [ 10x genomics]

(Submitter supplied) High numbers of tissue-resident memory T (TRM) cells have been associated with better clinical outcomes in cancer patients. However, the molecular characteristics that drive their efficient immune response to tumors are poorly understood. Here, using single-cell and bulk transcriptomic analysis of purified populations of TRM and non-TRM cells we characterise these populations
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
6 Samples
Download data: TXT
Series
Accession:
GSE111896
ID:
200111896

PubMed Full text in PMC Similar studies SRA Run Selector

17.

Single-cell transcriptomic analysis of tissue resident memory T cells in human lung cancer [scRNA-seq]

(Submitter supplied) High numbers of tissue-resident memory T (TRM) cells have been associated with better clinical outcomes in cancer patients. However, the molecular characteristics that drive their efficient immune response to tumors are poorly understood. Here, using single-cell and bulk transcriptomic analysis of purified populations of TRM and non-TRM cells we characterise these populations
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
1084 Samples
Download data: TXT
Series
Accession:
GSE111894
ID:
200111894

PubMed Full text in PMC Similar studies SRA Run Selector

18.

Single-cell transcriptomic analysis of tissue resident memory T cells in human lung cancer [ bulk RNA-seq]

(Submitter supplied) High numbers of tissue-resident memory T (TRM) cells have been associated with better clinical outcomes in cancer patients. However, the molecular characteristics that drive their efficient immune response to tumors are poorly understood. Here, using single-cell and bulk transcriptomic analysis of purified populations of TRM and non-TRM cells we characterise these populations
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
133 Samples
Download data: BW, TXT
Series
Accession:
GSE111892
ID:
200111892

PubMed Full text in PMC Similar studies SRA Run Selector

19.

SiEs05_LN_TCR

Organism:
Homo sapiens
Source name:
TCR of Tumor-infiltrating T cells
Platform:
GPL24676
Series:
GSE145691
Download data
Sample
Accession:
GSM4331053
ID:
304331053

SRA Run Selector

20.

SiEs05_T_TCR

Organism:
Homo sapiens
Source name:
TCR of Tumor-infiltrating T cells
Platform:
GPL24676
Series:
GSE145691
Download data
Sample
Accession:
GSM4331052
ID:
304331052

SRA Run Selector

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db=gds|term=Eschweilera%20wachenheimii|query=11|qty=3|blobid=MCID_6730caa209f698588762a925|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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