Croton quisumbingianus - GEO DataSets

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Select item 2001435691.

MrgprD-expressing neurons maintain cutaneous mast cell homeostasis

(Submitter supplied) This study shows that croton oil has a specific inflammatory signature involving altered expression of cytokines that is quantitatively altered by long-term LC ablation.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
14 Samples

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Series

Accession:: GSE143569

ID:: 200143569

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000897462.

Prediction of Cross-resistance and Collateral Sensitivity by Gene Expression profiles and Genomic Mutations.

(Submitter supplied) In adaptive evolution, an increase in fitness to an environment is frequently accompanied by changes in fitness to other environmental conditions, called cross-resistance and sensitivity. Although the networks between fitness changes affect the course of evolution substantially, the mechanisms underlying such fitness changes are yet to be fully elucidated. Herein, we performed high-throughput laboratory evolution of Escherichia coli under various stress conditions using an automated culture system, and quantified how the acquisition of resistance to one stressor alters the resistance to other stressors. more...

Organism:: Escherichia coli; Escherichia coli str. K-12 substr. MDS42

Type:: Expression profiling by array

Platform:: GPL18948
124 Samples

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Series

Accession:: GSE89746

ID:: 200089746

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000560673.

Epidermal RelA specifically restricts contact allergen-induced inflammation and apoptosis in skin

(Submitter supplied) Strong inhibition of NF-kB signaling in the epidermis results in spontaneous skin inflammation in mice and men. Since there is evidence for linkage between polymorphisms within the NF-kB signaling pathway and human inflammatory skin phenotypes, we asked whether partial functional inhibition of NF-kB signaling in epidermal keratinocytes can modulate clinically relevant skin inflammation. We therefore mutated rela specifically in the epidermis of mice (RelAE-MUT mice). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
4 Samples

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Series

Accession:: GSE56067

ID:: 200056067

Select item 2000591514.

REDD1 (regulated in development and DNA damage response 1) dissociates therapeutic and adverse effects of topical steroids in skin

(Submitter supplied) Even though cutaneous atrophy is the major adverse effect of topical glucocorticoids, its molecular mechanisms are poorly understood. We found that glucocorticoids strongly increased the expression of REDD1 (regulated in development and DNA damage response 1), a stress-inducible inhibitor of mTOR, in mouse and human epidermis. We found that REDD1 knockout animals are partially resistant to glucocorticoid-induced epidermal and subcutaneous adipose atrophy which correlated with the protection of CD34+ follicular epithelial stem cells as well as p63+ keratinocyte progenitors in REDD1 knockout epidermis during chronic steroid treatment. more...