GEO DataSets

(Submitter supplied) Bone and soft tissue sarcomas are rare and highly heterogeneous mesenchymal malignancies. Their rarity makes it difficult to acquire clinical data of patients with specific histological subtypes of sarcoma from large clinical trials. The diagnoses and treatment of sarcomas need to be further developed. We show that a long non-coding RNA (lncRNA) HAR1B may serve as predictive biomarkers for pazopanib treatment in bone and soft tissue sarcomas. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL21185

39 Samples

Download data: TXT, XLSX

(Submitter supplied) In recent times, long-term stay has become a common occurrence in the International Space Station (ISS). However, adaptation to the space environment can sometimes pose physiological problems to the astronauts after their return. Therefore, it is important to develop healthcare technologies for astronauts. In this study, hair, an easy-to-obtain sample, was identified as the candidate. In order to investigate the genetic changes in human hair during space flight, the hair follicles of 10 astronauts were analyzed by DNA microarray and real time q-PCR analyses.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13497

60 Samples

Download data: TXT

(Submitter supplied) The effect of microgravity on gene expression in C.elegans was comprehensively analysed by DNA microarray. This is the first DNA microarray analysis for C.elegans grown under microgravity. Hyper gravity and clinorotation experiments were performed as reference against the flight experiment.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL200

5 Samples

Download data: CEL

(Submitter supplied) TP53 R175H mutation is one of the most common mutations in human cancers and cancer cells with this mutation stably express R175H protein in the nucleus. To identify the synthetic lethal gene interacted with the R175H, we conducted the high throughput screening by using tetracyclin inducible R175H expression system in SF126 cells and comprehensive shRNA library carried by lenti virus. We identified 906 candidate gene suppressions that may lead to accelerated cell growth inhibition under the presence of R175H. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL14820

3 Samples

Download data: TXT

(Submitter supplied) To realistically evaluate the effects of the environment in space, it is necessary to understand the effects of external factors during sample transport from Earth to space. The present study focused on temperature, profiling the altered gene expression that develops under low cultivation temperatures in C. elegans, used as a space life science model. The 7903 genes were selected as differentially expressed genes, and divided into five sets with similar expression patterns using k-means clustering. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL7727

12 Samples

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