asterocarpus nervous - GEO DataSets

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Select item 2002783091.

The Novel miR_146-Tfdp2 Axis Antagonizes METH-Induced Apoptosis and Cell Cycle Abnormalities in Tree Shrew Primary Neurons

(Submitter supplied) This project focuses on the neurotoxic effects of methamphetamine (METH) abuse and its impact on the central nervous system. Methamphetamine is a highly addictive synthetic drug that can cause severe cognitive and behavioral changes, as well as neurodegenerative diseases. We conducted transcriptome sequencing on METH-treated primary neurons from tree shrews to investigate the underlying mechanisms of METH-induced neuronal damage.

Organism:: Tupaia belangeri

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL24233
8 Samples

Download data: TXT

Series

Accession:: GSE278309

ID:: 200278309

Select item 2002534692.

Effects of Denervation on Muscle Function

(Submitter supplied) Innervation of skeletal muscle fibers plays a crucial role in the maintenance of muscle tone and normal functioning, but little is known to date about denervated muscle atrophy and its underlying mechanisms. To this end, we performed RNA sequencing of skeletal muscle from sciatic nerve-excised C57BL/6 and BALB/c mice to investigate the underlying mechanisms of denervated skeletal muscle atrophy.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23479
12 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE253469

ID:: 200253469

Select item 2002609293.

Identification of IL-10 producing T cells in CSF and blood during treatment of subarachnoid neurocysticercosis

(Submitter supplied) Neurocysticercosis (NCC) is a parasitic infection that affects the central nervous system and is increasingly found in patients in non-endemic regions. Subarachnoid neurocysticercosis (SANCC) is the most severe form of this disease and is largely responsible for mortality associated with NCC. Inflammation is often an important factor in the treatment of SANCC as overactivity can lead to serious complications, but suppression induced by anti-inflammatory molecules – namely interleukin 10 (IL-10) – can lead to an increased time to cure. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
2 Samples

Download data: DEMUXLET, TSV

Series

Accession:: GSE260929

ID:: 200260929

Select item 2002805794.

PKC modulator bryostatin-1 therapeutically targets CNS innate immunity to attenuate neuroinflammation and promote remyelination [invitro]

(Submitter supplied) In multiple sclerosis (MS), microglia and macrophages within the central nervous system (CNS) play an important role in determining the balance between myelin repair and demyelination/neurodegeneration. Phagocytic and regenerative functions of these CNS innate immune cells support remyelination, whereas chronic and maladaptive inflammatory activation promotes lesion expansion and disability, particularly in the progressive forms of MS. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
27 Samples

Download data: TSV

Series

Accession:: GSE280579

ID:: 200280579

Select item 2002805785.

PKC modulator bryostatin-1 therapeutically targets CNS innate immunity to attenuate neuroinflammation and promote remyelination [exvivo]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: SF

Series

Accession:: GSE280578

ID:: 200280578

Select item 2002768036.

Fenebrutinib, a Bruton’s tyrosine kinase inhibitor, blocks distinct human microglial signaling pathways

(Submitter supplied) Bruton’s tyrosine kinase (BTK) is an intracellular signaling enzyme that regulates B cell and myeloid cell functions. Due to its involvement in both innate and adaptive immune compartments, inhibitors of BTK have emerged as a therapeutic option in autoimmune disorders such as multiple sclerosis (MS). Brain penetrant small molecule BTK inhibitors may also help to address compartmentalized neuroinflammation which is proposed to underlie MS disease progression. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
23 Samples

Download data: GCT

Series

Accession:: GSE276803

ID:: 200276803

Select item 2002047027.

A cross-disease human microglial framework identifies disease-enriched subsets and tool compounds for microglial polarization II.

(Submitter supplied) Human microglia play a pivotal role in neurological diseases, but few targeted therapies that directly modulate microglial state or function exist due to an incomplete understanding of microglial heterogeneity. We use single-cell RNA sequencing to profile live human microglia from autopsies or surgical resections across diverse neurological diseases and central nervous system regions. We observe a central divide between oxidative and heterocyclic metabolism and identify subsets associated with antigen presentation, motility, and proliferation. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL20301 GPL24676
67 Samples

Download data: H5

Series

Accession:: GSE204702

ID:: 200204702

PubMed Similar studies

Select item 2002025568.

A cross-disease human microglial framework identifies disease-enriched subsets and tool compounds for microglial polarization.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
12 Samples

Download data: TXT

Series

Accession:: GSE202556

ID:: 200202556

PubMed Similar studies

Select item 2002726699.

The single-cell assessment of transcriptiomic profile and chromain accessibility for the brain myeloid cells in rhesus macaques with SIV-induced encephalitis

(Submitter supplied) Human immunodeficiency virus (HIV) is widely recognized for its striking impact on the immune system, and it also significantly impacts the central nervous system (CNS). The primary immune constituents in the brain, microglia and macrophages, are the target for HIV in people and the simian immunodeficiency virus (SIV) in nonhuman primates. This infection can lead to neurological dysfunction, known as HIV-associated neurocognitive disorder (HAND) and pathological entities such as HIV-induced encephalitis (HIVE). more...

Organism:: Macaca mulatta

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL27943
8 Samples

Download data: H5, TSV

Series

Accession:: GSE272669

ID:: 200272669

PubMed Full text in PMC Similar studies

Select item 20024169710.

Microbiota-dependent early life programming of gastrointestinal motility

(Submitter supplied) Gastrointestinal microbes modulate peristalsis and stimulate the enteric nervous system (ENS), whose development, as in the central nervous system (CNS), continues into the murine postweaning period. Given that adult CNS function depends on stimuli received during critical periods of postnatal development, we hypothesized that adult ENS function, namely motility, depends on microbial stimuli during similar critical periods. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
24 Samples

Download data: CSV, TXT

Series

Accession:: GSE241697

ID:: 200241697

PubMed Full text in PMC Similar studies

Select item 20027913211.

Transcriptional profiles of microglia-like progeny cells derived from Cx3cr1 haplo-insufficient HSPCs and wild-tyoe HSPCs

(Submitter supplied) Favoring the engraftment and maturation of the engineered HSPCs in the central nervous system could allow enhancing further the therapeutic potential of the transplantation of engineered HSPCs for treating neurometabolic diseases. We propose a gene addition strategy involving Cx3cr1, a microglia chemokine receptor regulating microglia ontogeny and function. Here we characterize the transcriptional profile of microglia-like cell generated by Cx3cr1 haplo-insufficient and WT HSPC

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
2 Samples

Download data: MTX, TSV

Series

Accession:: GSE279132

ID:: 200279132

Select item 20022960312.

Protocadherin 8 and transcription factor Dbx1 regulate the formation of developing cerebral cortex

(Submitter supplied) Normal development of the mammalian central nervous system requires correct tissue patterning, production of the appropriate cell types and establishment of functional neuronal circuits. Transcription factors (TFs) play essential roles in these processes, regulating the expression of target genes responsible for neuronal subtypes specific features. Cell adhesion molecules are key components of neuronal identities that control cell sorting, migration, neurite outgrowth/guidance and synaptogenesis. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
1 Sample

Download data: MTX, TSV

Series

Accession:: GSE229603

ID:: 200229603

Select item 20027698713.

Endogenous self-peptides guard CNS immune privilege [TCR-seq]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
4 Samples

Download data: TAR

Series

Accession:: GSE276987

ID:: 200276987

Select item 20027305114.

Endogenous self-peptides guard CNS immune privilege [TCR_Dura-dCLN]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: TAR

Series

Accession:: GSE273051

ID:: 200273051

Select item 20027290115.

Endogenous self-peptides guard CNS immune privilege

Organism:: Mus musculus

Type:: Other

Platform:: GPL24247
3 Samples

Download data: TAR

Series

Accession:: GSE272901

ID:: 200272901

Select item 20024069116.

MHC-II peptidome of the CNS reveals endogenous guardian peptides

(Submitter supplied) The central nervous system (CNS), despite the presence of strategically positioned anatomical barriers designed to protect it, is not entirely isolated from the immune system. In fact, it remains physically connected to and can be influenced by the peripheral immune system. How the CNS retains such responsiveness while maintaining “immune privilege” remains an outstanding conundrum. In searching for molecular cues that derive from the CNS and allow its direct communication with the immune system, we discovered a repertoire of CNS-derived endogenous guardian peptides presented on major histocompatibility complex (MHC) II molecules at the CNS borders. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
2 Samples

Download data: TAR

Series

Accession:: GSE240691

ID:: 200240691

Select item 20027629917.

Comparison of DNA Methylation Based Classification Models for Precision Diagnostics of Central Nervous System Tumors

(Submitter supplied) As part of the advancement in therapeutic decision-making for brain tumor patients at St. Jude Children’s Research Hospital (SJCRH), we developed three robust classifiers, a deep learning neural network (NN), k-nearest neighbor (kNN), and random forest (RF), trained on a reference series DNA-methylation profiles to classify central nervous system (CNS) tumor types. The models’ performance was rigorously validated against 2,054 samples from two independent cohorts. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL21145
950 Samples

Download data: IDAT, TXT

Series

Accession:: GSE276299

ID:: 200276299

PubMed Full text in PMC Similar studies

Select item 20027211118.

Sequencing-based study of neural induction of human dental pulp stem cells

(Submitter supplied) This study aimed to evaluate the cellular components and differentiation pathways of neural lineage cells obtained via neural induction of human DPSCs. Human DPSCs were induced to neural cells in monolayer culture. The neural lineage cells were subjected to single-cell RNA sequencing (scRNA-seq) to classify cell populations based on gene expression profiles and elucidate their differentiation pathways. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
1 Sample

Download data: MTX, TSV

Series

Accession:: GSE272111

ID:: 200272111

Select item 20025024419.

Identification of new therapeutic candidates for Congenital Central Hypoventilation Syndrome

(Submitter supplied) Congenital central hypoventilation syndrome (CCHS), a rare genetic disease caused by heterozygous PHOX2B mutations, is characterized by life-threatening breathing deficiencies. PHOX2B is a transcription factor required for the specification of the autonomous nervous system that contains respiratory centers. To date, the only treatment offered to patients is mechanical ventilatory support. Therefore, identifying molecules with potential alleviating effects is of prime importance. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21290
12 Samples

Download data: TXT

Series

Accession:: GSE250244

ID:: 200250244

PubMed Full text in PMC Similar studies

Select item 20023342420.

Maternal immune activation upregulates the AU020206-IRFs-STAT1 axis in modulating cytokine production in the brain

(Submitter supplied) Maternal immune activation (MIA) is reported to increase the risk of psychiatric disorders in the offspring. However, the underlying mechanism remains unclear. Here, we constructed an MIA mouse model by intraperitoneal injection of LPS into pregnant mice and evaluated the behaviors and gene expression profiles in the brains of the female and male offspring, respectively. We found that the MIA female offspring exhibited increased anxiety and a large number of differentially expressed genes (DEGs) in the brain, which were enriched with disease genes of psychiatric disorders and immune functions. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
18 Samples

Download data: TXT

Series

Accession:: GSE233424

ID:: 200233424

PubMed Full text in PMC Similar studies

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