Alectorolophus minor - GEO DataSets

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Select item 2002757461.

Most adult gonadotrophs originate from postnatal pituitary stem cells during minipuberty.

(Submitter supplied) In the first three weeks postnatally, the pituitary gland undergoes a period of rapid growth, due to both cell proliferation and endocrine cell size increase. SCs are initially the most proliferative, and lineage tracing experiments previously showed that neonatal SCs can give rise to all endocrine cell types. However, because the Cre drivers used for lineage tracing were relatively inefficient and relied on tamoxifen, a selective estrogen receptor modulator which perturbs normal physiology, we could not decipher SC contribution to organ growth. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
2 Samples

Download data: MTX, TSV

Series

Accession:: GSE275746

ID:: 200275746

Select item 2002765542.

Large-scale manipulation of radial positioning does not affect most aspects of genome organization

(Submitter supplied) Although the spatial organization of the genome is closely linked to biological function, genome structure is highly stochastic. Within this heterogeneity, specific function-associated structural elements must be maintained, even when the nucleus is deformed due to physiological physical constraints. The radial positioning of genomic loci - their distance from the nuclear periphery - has long been considered an important feature of genome organization which is correlated with both structural elements and genomic activity. more...

Organism:: Homo sapiens

Type:: Other

Platforms:: GPL30173 GPL28038
8 Samples

Download data: MCOOL

Series

Accession:: GSE276554

ID:: 200276554

Select item 2002764383.

High-fat and High-sucrose Diets Synergistically Induce reticular pseudo-drusen (RPD)-like Lesions in Rabbits

(Submitter supplied) Age-related macular degeneration (AMD) is a leading cause of blindness. Metabolic disorders and diets are risk factors. We compared lipid profiles and retinal phenotypes with long-term feeding of four diets in male Chinchilla rabbits. Animals were fed with normal diet (ND), high fat diet (HFD), high sucrose diet (HSD), or high-fat and high-sucrose diet (HFSD) for six months. The eyes were examined using multimodal imaging modalities and electroretinogram (ERG). more...

Organism:: Oryctolagus cuniculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21255
8 Samples

Download data: TXT

Series

Accession:: GSE276438

ID:: 200276438

Select item 2002751264.

Subthreshold rejection activity in many kidney transplants currently classified as having no rejection.

(Submitter supplied) Most kidney transplant patients who undergo biopsies are classified as having no rejection based on consensus thresholds. However, we hypothesized that because these patients have normal adaptive immune systems, T cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR) may exist as subthreshold activity in some transplants currently classified as no rejection. Subthreshold molecular TCMR and/or ABMR activity molecular activity was detectable as elevated classifier scores in many biopsies classified as no rejection, with ABMR activity in many TCMR biopsies and TCMR activity in many ABMR biopsies. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13667
5086 Samples

Download data: CEL, TXT

Series

Accession:: GSE275126

ID:: 200275126

PubMed Similar studies

Select item 2002665265.

Device-free isolation of photoreceptor cells from patient iPSC-derived retinal organoids

(Submitter supplied) Purpose: Autologous cell replacement shows great promise for the treatment of inherited retinal degeneration. While mature differentiation protocols exist to produce retinal organoids from patient-derived stem cells, not all cell types present in these organoids are desirable for transplant. To increase the potency of future cell therapies, methods for isolating photoreceptors from dissociated retinal organoids are needed. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
19 Samples

Download data: CSV

Series

Accession:: GSE266526

ID:: 200266526

Select item 2002430756.

DNA methylation profiling of salivary gland tumors

(Submitter supplied) Tumors of the major and minor salivary gland encompass a diverse spectrum of diagnostically challenging neoplasms. Recent studies have identified several gene fusions and somatic mutations that are specific or highly enriched in certain salivary gland tumor entities and can assist histopathological diagnosis. Still, there is an unmet need to identify additional diagnostic biomarkers for entities lacking specific alterations. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL21145
363 Samples

Download data: CSV, IDAT

Series

Accession:: GSE243075

ID:: 200243075

Select item 2002728507.

Polyclonal interactions overcome fitness barriers in Apc-driven intestinal tumorigenesis

(Submitter supplied) Loss-of-function mutations in the tumour suppressor APC are an initial step in intestinal tumorigenesis. APC-mutant intestinal stem cells (ISCs) outcompete their wild type neighbours through the secretion of Wnt antagonists, accelerating the fixation and subsequent rapid clonal expansion of mutants. Reports of polyclonal intestinal tumours in patients and mouse models appear at odds with this process. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
63 Samples

Download data: TSV

Series

Accession:: GSE272850

ID:: 200272850

Select item 2002665568.

Seq-Scope profiling of mouse colon sections with biopsy-induced injuries

(Submitter supplied) We used Sequence-Scope (Seq-Scope), which can generate ultra-high definition images of sequence-based molecular signatures resolved at a submicrometer scale, for profiling spatial transcriptome associated with biopsy-associated colon injury. Raw 1st-Seq FASTQ with intact tile and coordinate information could be retrieved from https://doi.org/10.5281/zenodo.13118097

Organism:: Mus musculus; synthetic construct

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL33944 GPL19604
2 Samples

Download data: MTX, TSV

Series

Accession:: GSE266556

ID:: 200266556

Select item 2002321839.

Identifying key regulatory networks and predicting targets of orphan box C/D SNORD116 snoRNAs in Prader-Willi Syndrome

(Submitter supplied) To identify the targets and functions of SNORD116 snoRNAs, we engineered two different deletions mimicking those seen in Prader-Willi Syndrome (PWS) patients into two distinct human embryonic stem cell lines to control for effects of genetic background. We also introduced an inducible Neurogenin-2 cassette into the safe-harbor AAVS1 locus to enable quick and reproducible differentiation into neurons. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL21697
39 Samples

Download data: TXT

Series

Accession:: GSE232183

ID:: 200232183

Select item 20026418910.

Premature aging effects on COVID-19 pathogenesis: new insights from mouse models

(Submitter supplied) Aging is identified as a significant risk factor for severe coronavirus disease-2019 (COVID-19), often resulting in profound lung damage and mortality. Yet, the biological relationship between aging, aging-related comorbidities, and COVID-19 remains incompletely understood. This study aimed to elucidate the age-related COVID19 pathogenesis using a Hutchinson-Gilford progeria syndrome (HGPS) mouse model with humanized ACE2 receptors. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28330
42 Samples

Download data: CSV

Series

Accession:: GSE264189

ID:: 200264189

Select item 20027533111.

In vivo contribution of Cyp24a1 promoter vitamin D response elements

(Submitter supplied) CYP24A1 is a multifunctional, P450 mitochondrial 24-hydroxylase enzyme that is responsible for catabolism of the most active vitamin D hormone (calcitriol, 1,25(OH)2D3), its precursor (calcifediol, 25(OH)D3), and numerous other vitamin D metabolites at the 23- and 24-carbon positions. Cyp24a1 gene expression is induced by 1,25(OH)2D3 in all tissues that contain the vitamin D receptor in a feedback mechanism. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL34328
31 Samples

Download data: BIGWIG

Series

Accession:: GSE275331

ID:: 200275331

Select item 20027435012.

Assessing a single-cell multi-omic analytic platform to characterize ex vivo-engineered T cell therapy products

(Submitter supplied) Genetically engineered CD8+ T cells are being explored for the treatment of various cancers. Analytical characterization represents a major challenge in the development of genetically engineered cell therapies, especially assessing the potential off-target editing and product heterogeneity. As conventional sequencing techniques only provide information at the bulk level, they are unable to detect off-target CRISPR translocation or editing events occurring in minor cell subpopulations. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL24676
16 Samples

Download data: TSV

Series

Accession:: GSE274350

ID:: 200274350

Select item 20026858513.

Modelling inflammation-induced peripheral sensitization in a dish – more complex than expected?

(Submitter supplied) Peripheral sensitization of nociceptors is believed to be a key driver of chronic pain states. Here, we sought to study the effects of a modified version of inflammatory soup on the excitability of human stem-cell derived sensory neurons. For this, we used a pre-existing and a novel stem cell line, modified to stably express the calcium sensor GCamP6f. Upon treatment with inflammatory soup, we observed no changes in neuronal transcription or functional responses upon calcium imaging, and only a very minor increase in resting membrane potential via whole cell patch clamping. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
19 Samples

Download data: CSV, XLSX

Series

Accession:: GSE268585

ID:: 200268585

Analyze with GEO2R

Select item 20024284514.

Dual Gene Expression Analysis Identifies Factors Associated with Staphylococcus aureus Virulence in Diabetic Mice

(Submitter supplied) Staphylococcus aureus is a major human pathogen of the skin. The global burden of diabetes is high, with S. aureus being a major complication of diabetic wound infections. We investigated how the diabetic environment influences S. aureus skin infection and observed an increased susceptibility to infection in mouse models of both type I and type II diabetes. A dual gene expression approach was taken to investigate transcriptional alterations in both the host and bacterium after infection. more...

Organism:: Staphylococcus aureus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24034
8 Samples

Download data: XLS

Series

Accession:: GSE242845

ID:: 200242845

Select item 20027116015.

Keratinocyte glucocorticoids enable local immune resilience to preserve skin homeostasis.

(Submitter supplied) Endogenous glucocorticoids (GCs) are pivotal in controlling inflammation. Keratinocyte-derived GCs contribute to local skin homeostasis as deletion of the GC-producing enzyme 11β-hydroxylase (Cyp11b1) in keratinocytes exacerbated skin inflammation. Since local tamoxifen-induced knockout (KO) induction may contribute to skin irritation, we implemented intraperitoneal injections to induce a systemic skin GC depletion preventing experimental skin irritation in order to reveal the importance of skin GC in steady-state. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
20 Samples

Download data: TXT

Series

Accession:: GSE271160

ID:: 200271160

Select item 20025602216.

Amniotic Fluid Alters Differentiation of Esophageal Epithelial Cells and Amplifies Pro-Allergic Response.

(Submitter supplied) Background There is emerging evidence that the risk of inflammatory diseases in childhood such as eosinophilic esophagitis (EoE) is influenced by in-utero events, as prenatal complications increase the risk for the diseases. Objective We propose that the exposure of esophageal epithelium to amniotic fluid (AF) leads to alterations in its differentiation program and responsiveness to pro-allergic stimuli. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
32 Samples

Download data: TXT

Series

Accession:: GSE256022

ID:: 200256022

Analyze with GEO2R

Select item 20022998917.

Targeted disruption of BCL11A-XL specific zinc finger motif for de-repression of fetal globin expression

(Submitter supplied) BCL11A is a major gamma globin repressor widely used target for the clinical amelioration of beta-hemoglobinopathies. The longer BCL11A-XL isoform has three distinct ZnF domains at the C-terminal which has been implicated in DNA interactions with the HBG region. These unique ZnF domains harbor missense mutations in neurodevelopmental disorder patients and have been shown to elevate HbF levels with normal hematological parameters. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
8 Samples

Download data: TXT

Series

Accession:: GSE229989

ID:: 200229989

Analyze with GEO2R

Select item 20025314618.

Pharmacokinetic modeling and gene sequencing reveal the interplay between B vitamins and probiotics

(Submitter supplied) The pharmacological significance of B vitamins, essential for various metabolic processes, and the therapeutic potential of probiotics in gastrointestinal health have been well-documented. However, the interactions between these entities remain poorly understood. In this study, we endeavored to elucidate the potential interplay between B vitamins and probiotics utilizing liquid chromatography-triple quadrupole mass spectrometry, pharmacokinetic modeling, and 16S rRNA gene sequencing. more...

Organism:: Rattus norvegicus

Type:: Other

Platform:: GPL32027
25 Samples

Download data: FASTA

Series

Accession:: GSE253146

ID:: 200253146

Select item 20026145819.

Single cell RNA sequencing of aging neural progenitors reveals loss of excitatory neuron potential and a population with transcriptional immune response (scRNA-Seq)

(Submitter supplied) In the adult murine brain, neural stem cells (NSCs) reside in two main niches, the dentate gyrus (DG), and the subventricular zone (SVZ). In the DG, NSCs give rise to intermediate progenitors that differentiate into excitatory neurons, while progenitors in the SVZ migrate to the olfactory bulb (OB) where they mainly differentiate into inhibitory interneurons. Neurogenesis, the production of new neurons, persists throughout life but decrease dramatically during aging, concomitantly with increased inflammation. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
9 Samples

Download data: MTX, TSV

Series

Accession:: GSE261458

ID:: 200261458

Select item 20026145720.

Single cell RNA sequencing of aging neural progenitors reveals loss of excitatory neuron potential and a population with transcriptional immune response (RNA-Seq)

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
40 Samples

Download data: TXT

Series

Accession:: GSE261457

ID:: 200261457

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