A Attanasio - GEO DataSets

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Select item 2002720711.

Klf2/4-independent effects of Pcdhg on gene expression in endothelial cells exposed to Oscillatory Shear Stress (OSS)

(Submitter supplied) We found that Pcdhg is a potent suppressor of Klf2/4 in endothelial cells. We performed RNAseq analysis to characterize deregulated pathways and processes by which Pcdhg may regulate Klf2/4.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
9 Samples

Download data: XLSX

Series

Accession:: GSE272071

ID:: 200272071

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002382002.

Activation of endogenous retroviruses and induction of viral mimicry by MEK1/2 inhibition in pancreatic cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL18573
123 Samples

Download data: BW

Series

Accession:: GSE238200

ID:: 200238200

PubMed Full text in PMC Similar studies

Select item 2002381983.

Activation of endogenous retroviruses and induction of viral mimicry by MEK1/2 inhibition in pancreatic cancer [RNA-seq]

(Submitter supplied) While pancreatic ductal adenocarcinomas (PDAC) are addicted to KRAS-activating mutations, inhibitors of downstream effectors in the KRAS pathway, such as the clinically approved MEK1/2 kinases inhibitor Trametinib, are devoid of significant therapeutic effects. Nevertheless, the extensive rewiring of regulatory circuits driven by the attenuation of the KRAS pathway can induce novel functional states and vulnerabilities of potential therapeutic relevance. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL18573
72 Samples

Download data: BW, TXT

Series

Accession:: GSE238198

ID:: 200238198

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002381974.

Activation of endogenous retroviruses and induction of viral mimicry by MEK1/2 inhibition in pancreatic cancer [ChIP-seq]

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL24676 GPL18573
51 Samples

Download data: BW

Series

Accession:: GSE238197

ID:: 200238197

PubMed Full text in PMC Similar studies

Select item 2001929445.

Treatment of MM cells with non-targeting (NT) or ILF2 targeting oligonucleotide antisenses (ASOs)

(Submitter supplied) To gain insights into the molecular mechanisms by which myeloma cells overcome ILF2 ASO-induced DNA damage activation, we performed bulk RNA sequencing (RNA-seq) analysis of ASO-treated KMS11 and JJN3 cells at early (1 week) and late (3 weeks) treatment time points.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
24 Samples

Download data: TSV

Series

Accession:: GSE192944

ID:: 200192944

PubMed Full text in PMC Similar studies

Select item 2001967666.

Targeting DNA2 Overcomes Metabolic Reprogramming in Multiple Myeloma

(Submitter supplied) Targeting DNA2 is synthetically lethal in myeloma cells that undergo metabolic adaptation and rely on oxidative phosphorylation to maintain survival after DNA damage activation.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
14 Samples

Download data: H5

Series

Accession:: GSE196766

ID:: 200196766

PubMed Full text in PMC Similar studies

Select item 2002184047.

Precision RNAi using synthetic shRNAmir target sites

(Submitter supplied) Loss-of-function genetic tools are widely applied for validating therapeutic targets, but their utility remains limited by incomplete on- and uncontrolled off-target effects. We describe artificial RNA interference (ARTi) based on synthetic, ultra-potent, off-target-free shRNAs that enable efficient, inducible, and reversible suppression of any gene upon introduction of a synthetic target sequence into non-coding transcript regions. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
36 Samples

Download data: TSV

Series

Accession:: GSE218404

ID:: 200218404

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002029108.

RNA sequencing of different GEMMs of prostate cancer

(Submitter supplied) Prostate cancers of different genetic backgrounds were subjected to polysome profiling analysis to identify the extracellular interactome between prostate cancer and myeloid-derived suppressor cells.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
27 Samples

Download data: TXT

Series

Accession:: GSE202910

ID:: 200202910

PubMed Full text in PMC Similar studies

Select item 2002029079.

RNA sequencing of myelod derived suppressor cells (MDSCs) and Bone marrow (BM)

(Submitter supplied) Myeloid-derived suppressor cells were subjected to polysome profiling analysis to identify the expressed membrane-tethered proteins involved in their recruitment into prostate cancer.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
18 Samples

Download data: TXT

Series

Accession:: GSE202907

ID:: 200202907

PubMed Full text in PMC Similar studies

Select item 20022301410.

Chip seq of in vitro induced senescent myeloid cells treated with HDAC inhibitor

(Submitter supplied) To understand the epigenetic regulations in in vitro induced senescent myeloid cells, we used Romidepsin (regulator of hyston H3) and we analysed how the genes get regulated.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19057
4 Samples

Download data: BROADPEAK, BW

Series

Accession:: GSE223014

ID:: 200223014

PubMed Similar studies

Select item 20020007711.

RNA sequencing of in vivo sorted C12FDG+ MDSCs and C12FDG- MDSCs

(Submitter supplied) RNA sequencing of in vivo sorted C12FDG+ MDSCs and C12FDG- MDSCs

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
9 Samples

Download data: TXT

Series

Accession:: GSE200077

ID:: 200200077

PubMed Similar studies

Select item 20019992712.

RNA sequencing of in vivo sorted Trem2 mutant MDSCs and WT MDSCs

(Submitter supplied) RNA sequencing of in vivo sorted Trem2 mutant MDSCs and WT MDSCs

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
4 Samples

Download data: TXT

Series

Accession:: GSE199927

ID:: 200199927

PubMed Similar studies

Select item 20019992113.

RNA sequencing of BM-derived senescent MDSCs treated or not with Romidepsin

(Submitter supplied) RNA sequencing of BM-derived senescent MDSCs treated or not with Romidepsin

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
8 Samples

Download data: TXT

Series

Accession:: GSE199921

ID:: 200199921

PubMed Similar studies

Select item 20018951914.

single cell RNA sequencing of xenograft prostate cancer model under different treatment

(Submitter supplied) We performed single cell RNA sequencing of xenograft prostate cancer models to analyse effect of different drugs.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
3 Samples

Download data: TXT

Series

Accession:: GSE189519

ID:: 200189519

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20018930715.

single cell RNA sequencing of murine prostate cancer models

(Submitter supplied) We performed single cell RNA sequencing of Epcam+ sorted cells from murine prostate cancer models to characterize the epithelial compartment of the tumors.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
4 Samples

Download data: TXT

Series

Accession:: GSE189307

ID:: 200189307

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20018086316.

Next Generation Sequencing of Ruminicoccus Gnavus after pregnelonone exposure

(Submitter supplied) Examination of Ruminicoccus Gnavus gene expression profile after pregnelonone exposure

Organism:: Mediterraneibacter gnavus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30439
7 Samples

Download data: TXT

Series

Accession:: GSE180863

ID:: 200180863

PubMed Similar studies SRA Run Selector

Select item 20018202117.

Identification of EMT and EMT/Cilium-dependent gene expression signatures + Identification of breast tumors of the claudin-low molecular subtype among triple-negative breast cancers II

(Submitter supplied) The goal of the second gene expression analysis (samples 17-83) was to determine the molecular subtypes of human breast cancers of a triple-negative breast cancer (TNBC) biobank.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
66 Samples

Download data: TXT

Series

Accession:: GSE182021

ID:: 200182021

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20017378818.

An EMT-primary cilium-GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis

(Submitter supplied) The Epithelial–Mesenchymal Transition (EMT) and primary ciliogenesis induce stem cell properties in basal Mammary Stem Cells (MaSCs) to promote mammogenesis, but the underlying mechanisms remain incompletely understood. Here, we show that EMT transcription factors promote ciliogenesis upon intermediate EMT transition states by activating ciliogenesis inducers, including FGFR1. The resulting primary cilia promote BBS11-dependent ubiquitination and inactivation of a central signaling node, GLIS2. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
6 Samples

Download data: TXT

Series

Accession:: GSE173788

ID:: 200173788

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016054919.

Identification of EMT and EMT/Cilium-dependent gene expression signatures + Identification of breast tumors of the claudin-low molecular subtype among triple-negative breast cancers

(Submitter supplied) The goal of the first gene expression analysis reported here (Samples 1-16) was to establish gene expression signatures associated to activation of an Epithelial-Mesenchymal Transition (EMT) and primary ciliogenesis, in immortalized and non-transformed (HMLE) or transformed (HMLER) human mammary epithelial cells, respectively. The goal of the second gene expression analysis (Samples 17-83) was to determine the molecular subtypes of human breast cancers of a triple-negative breast cancer (TNBC) biobank.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
83 Samples

Download data: XLSX

Series

Accession:: GSE160549

ID:: 200160549

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20011829020.

RNA-seq in livers of wild-type (WT) controls, PiZ and PIZ mice deleted for Chop (PiZ/Chop-/-)

(Submitter supplied) Transgenic PiZ mice have been genetically engineered to express ATZ and have been a valuable experimental model for liver disease due to AAT polymerization. ATZ accumulates in these mice within the endoplamic reticulum (ER) of hepatocytes in a nearly identical manner to livers of affected patients. To investigate the role of the transcription factor CHOP in the pathogenesis of liver damage induced by ATZ, we performed RNA-seq in livers of 6-week-old wild type, PiZ and PiZ mice deleted for Chop. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
8 Samples

Download data: TXT

Series

Accession:: GSE118290

ID:: 200118290

SRA Run Selector

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