7-Ethylquinoline-3-carboxylic acid - GEO DataSets

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Select item 2002184381.

Structure Activity Relationship Read Across and Transcriptomics for Branched Carboxylic Acids

(Submitter supplied) The purpose of this study was to use chemical similarity evaluations, transcriptional profiling, in vitro toxicokinetic data and physiologically based pharmacokinetic (PBPK) models to support read across for a series of branched carboxylic acids using valproic acid (VPA), a known developmental toxicant, as a comparator. The chemicals included 2-propylpentanoic acid (VPA), 2-ethylbutanoic acid (EBA), 2-ethylhexanoic acid (EHA), 2-methylnonanoic acid (MNA), 2-hexyldecanoic acid (HDA), 2-propylnonanoic acid (PNA), dipentyl acetic acid (DPA) or 2-pentylheptanoic acid (PHA), octanoic acid (OA, a straight chain alkyl acid) and 2-ethylhexanol. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL25480
636 Samples

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Series

Accession:: GSE218438

ID:: 200218438

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Select item 2002461202.

Derivation of transcriptomics-based points of departure for twenty per- or polyfluoroalkyl substances (PFAS) using a larval fathead minnow (Pimephales promelas) reduced transcriptome assay.

(Submitter supplied) Traditional toxicity testing has been unable to keep pace with the introduction of new chemicals into commerce. Consequently, there are limited or no toxicity data upon which to base a risk assessment for many chemicals to which fish and wildlife may be exposed. Per- and polyfluoroalkyl substances (PFAS) are emblematic of this issue in that most the ecological hazards of most PFAS remain uncharacterized. more...

Organism:: Pimephales promelas

Type:: Expression profiling by high throughput sequencing

Platform:: GPL33861
888 Samples

Download data: CSV, TXT

Series

Accession:: GSE246120

ID:: 200246120

Select item 2002706083.

High-Throughput Screen Identifies Non-Inflammatory Small Molecule Inducers of Trained Immunity

(Submitter supplied) Trained immunity is a form of innate immune memory characterized by epigenetic and metabolic reprogramming in response to specific stimuli. This rewiring can result in increased cytokine and effector responses to pathogenic challenge, providing non-specific protection against disease. It may also improve immune responses to established immunotherapeutics and vaccines. Despite the promise of training for next-generation therapeutic design, most current understanding and experimentation is conducted with complex and heterogeneous biologically derived molecules, such as β-glucan or the BCG vaccine. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24247
28 Samples

Download data: NARROWPEAK, TXT

Series

Accession:: GSE270608

ID:: 200270608

Select item 2002432974.

Asymmetric bulges within hairpin RNA transgenes influence small RNA size, secondary siRNA production and viral defence

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Nicotiana tabacum; Arabidopsis thaliana

Type:: Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL23495 GPL26208 GPL29390
48 Samples

Download data: BED

Series

Accession:: GSE243297

ID:: 200243297

Select item 2002432965.

Asymmetric bulges within hairpin RNA transgenes influence small RNA size, secondary siRNA production and viral defence II

(Submitter supplied) Small RNAs (sRNAs) are essential for normal plant development and range in size classes of 21-24 nucleotides. The 22nt small interfering RNAs (siRNAs) and miRNAs are processed by Dicer-like 2 (DCL2) and DCL1 respectively and can initiate secondary siRNA production from the target transcript amplifying the silencing signal in plants. 22nt siRNAs are under-represented due to competition with DCL4, while only a small number of 22nt miRNAs exist due to the rare occurrence of an asymmetric bulge in the precursor miRNA stem. more...

Organism:: Arabidopsis thaliana

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL26208
20 Samples

Download data: BED

Series

Accession:: GSE243296

ID:: 200243296

Select item 2002441096.

A New Approach Methods Strategy for Risk-based Prioritization of PFAS [cardiomyocytes]

(Submitter supplied) Per- and polyfluoroalkyl substances (PFAS) are a very large (thousands of chemicals) category; these substances have important industrial and consumer product applications. PFAS are highly persistent in the environment, and some are known to pose human health hazard. Regulatory agencies worldwide are considering restrictions and outright bans of PFAS; however, little data exists to make informed decisions. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
197 Samples

Download data: CSV

Series

Accession:: GSE244109

ID:: 200244109

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002441077.

A New Approach Methods Strategy for Risk-based Prioritization of PFAS [hepatocytes]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
318 Samples

Download data: CSV

Series

Accession:: GSE244107

ID:: 200244107

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002441108.

Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
515 Samples

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Series

Accession:: GSE244110

ID:: 200244110

PubMed Full text in PMC Similar studies

Select item 2001458849.

Reprogramming of bacterial and plant sulfur metabolisms in Enterobacter sp. SA187-induced plant salt stress tolerance

(Submitter supplied) Although some mechanisms are known how plant growth beneficial bacteria help plants to grow under stressful conditions, we still know little how the metabolism of host plants and bacteria is coordinated during the establishment of functional interaction. In the present work, using single and dual transcriptomics, we studied the reprograming of metabolic and signaling pathways of Enterobacter sp. SA187 with Arabidopsis thaliana during the change from free-living to endophytic host-microbe interaction. more...

Organism:: Arabidopsis thaliana

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21785
18 Samples

Download data: XLSX

Series

Accession:: GSE145884

ID:: 200145884

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015456310.

SHAPE analysis of RNA structure in living cells with unprecedented accuracy

(Submitter supplied) Due to the mounting evidence that RNA structure plays a critical role in regulating almost any essential physiological as well as pathological process, being able to accurately define the folding of RNA molecules within living cells has become a crucial need. We introduce here 2-aminopyridine-3-carboxylic acid (2A3), as a general probe for the interrogation of RNA structures in vivo. 2A3 performs comparably well to NAI on naked RNA under in vitro conditions and it significantly outperforms NAI when probing RNA structure in vivo, particularly in bacteria, underlining its increased ability to permeate biological membranes. more...

Organism:: Bacillus subtilis; Escherichia coli; Homo sapiens

Type:: Other

Platforms:: GPL21222 GPL18573 GPL24109
36 Samples

Download data: WIG

Series

Accession:: GSE154563

ID:: 200154563

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016211311.

Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2 induced systemic toxicity

(Submitter supplied) SARS-CoV-2 primarily affects the respiratory system but extra-pulmonary manifestations in individuals with COVID-19 are commonly seen. All major organ systems have been reported to be affected by SARS-CoV-2 and complications arising from ensuing organ dysfunction significantly increase the mortality rate of COVID-19. Yet, despite the clinical importance of systemic involvement of SARS-CoV-2, little is known about the pathogenesis of extra-pulmonary complications of COVID-19. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL21493 GPL21290
71 Samples

Download data: TXT

Series

Accession:: GSE162113

ID:: 200162113

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013313612.

Physiological responses of Saccharomyces cerevisiae to industrially relevant conditions: slow growth, low pH and high CO2 levels

(Submitter supplied) Engineered strains of Saccharomyces cerevisiae are used for industrial production of succinic acid. Optimal process conditions for dicarboxylic-acid yield and recovery include slow growth, low pH and high CO2. To quantify and understand how these process parameters affect yeast physiology, this study investigates individual and combined impacts of low pH (3.0) and high CO2 (50 %) on slow-growing chemostat and retentostat cultures of the reference strain S. more...

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17342
26 Samples

Download data: CSV

Series

Accession:: GSE133136

ID:: 200133136

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20012204413.

MiR-29 Regulates de novo Lipogenesis in the Liver and Circulating Triglyceride Levels in a Sirt1-Dependent Manner

(Submitter supplied) Systematic comparison of multiple models of diabetes / insulin resistance reveals miR-29 as a commonality among them, and further analysis reveals it as a key therapeutic target for insulin resistance.

Organism:: Macaca mulatta; Mus musculus; Rattus norvegicus

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

5 related Platforms
84 Samples

Download data: CSV

Series

Accession:: GSE122044

ID:: 200122044

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011605814.

Hepatic transcript profiling in early lactating dairy cows fed rumen-protected niacin during the transition from late pregnancy to lactation

(Submitter supplied) In dairy cows, administration of high dosages of niacin (NA) was found to cause anti-lipolytic effects, which are mediated by the NA receptor hydroxyl-carboxylic acid receptor 2 (HCAR2) in white adipose tissue (WAT), and thereby to an altered hepatic lipid metabolism. However, almost no attention has been paid to possible direct effects of NA in cattle liver, despite showing that HCAR2 is expressed also in the liver of cattle and is even more abundant than in WAT. more...

Organism:: Bos taurus

Type:: Expression profiling by array

Platform:: GPL16500
18 Samples

Download data: CEL

Series

Accession:: GSE116058

ID:: 200116058

Select item 20007881415.

Investigation on the anaerobic propionate degradation by Escherichia coli K12

(Submitter supplied) Propionate is an abundant carboxylic acid in nature. Microorganisms metabolize propionate aerobically via the 2-methylcitrate pathway. This pathway depends on a series of three reactions in the citric acid cycle that leads to the conversion of succinate to oxaloacetate. Interestingly, the gamma-proteobacterium Escherichia coli can use propionate as a carbon and electron source under oxic but not under anoxic conditions. more...

Organism:: Escherichia coli K-12

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21547
16 Samples

Download data: TXT

Series

Accession:: GSE78814

ID:: 200078814

PubMed Similar studies SRA Run Selector

Select item 20007221516.

Real-time quantitative PCR analysis of tomato bZIP genes under biotic stress and plant hormone treatments

(Submitter supplied) We used Bio-Rad laboratories, lnc. PCR assay panel to analyze expression levels of bZIP genes in various biotci stress and plant hormone treatments. Tomato (Solanum lycopersicum) cv. Suhong 2003 were reared in growth chambers at 24 ± 1 °C with a photoperiod of 14 h light/10 h dark and light intensity of 200 μE m2 s-1. For analysis of gene expression, 4-week-old tomato plants were treated by foliar spraying with 100 μM methyl jasmonate (MeJA), 100 μM 1-amino cyclopropane-1-carboxylic acid (ACC), 100 μM SA or 0.1% ethanol as a control and samples were collected at indicated time points after treatment. more...

Organism:: Solanum lycopersicum

Type:: Expression profiling by RT-PCR

Platform:: GPL20829
13 Samples

Download data: TXT

Series

Accession:: GSE72215

ID:: 200072215

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005992717.

Drug Matrix Data - CodeLink Arrays

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platforms:: GPL5426 GPL5425 GPL5424
12921 Samples

Download data: TXT

Series

Accession:: GSE59927

ID:: 200059927

Analyze with GEO2R

Select item 20005992318.

Exposure of rat to a variety of toxicants, liver assayed by Codelink microarray

(Submitter supplied) DrugMatrix is a comprehensive rat toxicogenomics database and analysis tool developed to facilitate the integration of toxicogenomics into hazard assessment. Using the whole genome and a diverse set of compounds allows a comprehensive view of most pharmacological and toxicological questions and is applicable to other situations such as disease and development.