4-[bis-(p-Dimethylaminophenyl)methyl]-1,2-phenylenedimethanesulfonic a - GEO DataSets

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The following terms were not found in GEO DataSets: Dimethylaminophenyl, p-Dimethylaminophenyl, phenylenedimethanesulfonic, 2-phenylenedimethanesulfonic.
Unknown field was ignored: [bis-].
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Select item 2002624191.

Informing Hazard Identification and Risk Characterization of Environmental Chemicals by Combining Transcriptomic and Functional Data from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

(Submitter supplied) Cardiovascular disease remains a significant global health concern, yet the cardiotoxic effects of environmental chemicals are largely unexplored. Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-Cardiomyocytes) are well-established as valuable high-throughput cardiotoxicity testing model based on the analysis of various beating parameters; however, additional adverse effects that may not be directly related to ion channel activity are difficult to ascertain from traditional assays. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
4558 Samples

Download data: CSV

Series

Accession:: GSE262419

ID:: 200262419

Select item 2002169912.

Small Molecule Inducers of Neuroprotective miR-132 Identified by HTS-HTS in Human iPSC-derived Neurons

(Submitter supplied) MicroRNAs (miRNAs) are short RNAs that regulate fundamental biological processes. miR-132, a key miRNA with established functions in Tau homeostasis and neuroprotection, is consistently downregulated in Alzheimer’s disease (AD) and other tauopathies. miR-132 overexpression rescues neurodegenerative phenotypes in several AD models. To complement research on miRNA-mimicking oligonucleotides targeting the central nervous system, we developed a high-throughput-screen coupled high-throughput-sequencing (HTS-HTS) in human induced pluripotent stem cell (iPSC)-derived neurons to identify small molecule inducers of miR-132. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL21697
1441 Samples

Download data: XLSX

Series

Accession:: GSE216991

ID:: 200216991

PubMed Full text in PMC Similar studies

Select item 2001803623.

RRBS DNA methylation data of bovine embryonic fibroblast cells

(Submitter supplied) We investigated the effects of one carbon metabolites supplementation on early embryonic development. To this end, the Bovine Embryonic Tracheal Fibroblast cell lines (EBTr; NBL-4; ATCC CCL-44) were cultured under different levels of glucose and OCM (folic acid, choline chloride, vitamin B12, and L-methionine).

Organism:: Bos taurus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL26012
18 Samples

Download data: CSV

Series

Accession:: GSE180362

ID:: 200180362

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001580554.

Large-scale single-cell analysis reveals critical immune characteristics of COVID-19 patients

(Submitter supplied) We profiled scRNA-seq of 284 samples collected from 196 individuals, including 22 patients with mild/moderate symptoms, 54 hospitalized patients with severe symptoms, and 95 recovered convalescent persons, as well as 25 healthy controls. The samples were obtained from various tissue types, including human peripheral blood mononuclear cells (249), bronchoalveolar lavage fluid (12) and pleural pleural effusion (1)/sputum (22).

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL28038 GPL24676
284 Samples

Download data: CSV, MTX, TSV, XLSX

Series

Accession:: GSE158055

ID:: 200158055

PubMed Full text in PMC Similar studies

Select item 2001399585.

Systemic muscle wasting drives tumourigenesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17275
24 Samples

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Series

Accession:: GSE139958

ID:: 200139958

PubMed Full text in PMC Similar studies

Select item 2001542606.

Tuft cells restrain pancreatic tumorigenesis through paracrine eicosanoid signaling

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL21626 GPL17021
194 Samples

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Series

Accession:: GSE154260

ID:: 200154260

Select item 2001542587.

Tuft cells restrain pancreatic tumorigenesis through paracrine eicosanoid signaling [bulk RNA-seq]

(Submitter supplied) We performed bulk RNA-seq on pancreatic and intestinal tuft cells, bone marrow derived macrophages with various treatments, and mouse pancreatic stellate cells with various treatments.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
33 Samples

Download data: XLS

Series

Accession:: GSE154258

ID:: 200154258

SRA Run Selector

Select item 2000811428.

mRNA sequence of individual Drosophila melanogaster (w1118) male and female flies fed with different concentrations of dimethyl sulfoxide (DMSO) over different time periods.

(Submitter supplied) To gain an understanding of the toxic effect of a commonly used solvent, flies were exposed to 0, 0.1, 0.2, or 0.4% v/v DMSO for 0, 2, 4, or 8 h. We performed compound exposure of 800 individual flies in 4 Whole Animal Feeding Flats (WAFFL), a novel 96 well system to house, feed, and harvest individual flies. This expression profiling was part of a set of the experiments performed to evaluate the suitability of the WAFFL for high throughput small compound screening in D. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17275
96 Samples

Download data: TXT

Series

Accession:: GSE81142

ID:: 200081142

SRA Run Selector

Select item 2000702499.

Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration

(Submitter supplied) Environmental factors, including pesticides, have been linked to autism and neurodegeneration risk using retrospective epidemiological studies. Here, we sought to prospectively identify chemicals that share transcriptomic signatures with neurological disorders by exposing mouse cortical neuron-enriched cultures to hundreds of chemicals commonly found in the environment and on food. We find that rotenone, a pesticide associated with Parkinson’s disease risk, and certain fungicides, including pyraclostrobin, trifloxystrobin, famoxadone, and fenamidone, produce transcriptional changes in vitro that are similar to those seen in brain samples from humans with autism, advanced age and neurodegeneration (Alzheimer’s disease, Huntington’s disease). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
405 Samples

Download data: TXT

Series

Accession:: GSE70249

ID:: 200070249

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006843510.

Yeast m6A methylated mRNAs are enriched on translating ribosomes during meiosis, and under Rapamycin treatment

(Submitter supplied) Interest in mRNA methylation has exploded in recent years. The sudden interest in a 40 year old discovery was due in part to the recent finding of FTO?s (Fat Mass Obesity) N6-methyl-adenosine (m6A) deaminase activity, thus suggested a link between obesity-associated diseases and the presence of m6A in mRNA. Another catalyst of the sudden rise in mRNA methylation research was the release of mRNA methylomes for human, mouse and Saccharomyces cerevisiae. more...

Organism:: Schizosaccharomyces pombe; Saccharomyces cerevisiae; Saccharomyces cerevisiae SK1

Type:: Expression profiling by array

Platform:: GPL2529
12 Samples

Download data: CEL

Series

Accession:: GSE68435

ID:: 200068435

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006394711.

Transcriptome comparison of ectomycorrhizal, ericoid and orchid mycorrhizal fungi

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Paxillus involutus; Piloderma croceum; Serendipita vermifera; Suillus luteus; Amanita muscaria; Hebeloma cylindrosporum; Oidiodendron maius; Tulasnella calospora

Type:: Expression profiling by high throughput sequencing

10 related Platforms
42 Samples

Download data: TXT

Series

Accession:: GSE63947

ID:: 200063947

PubMed Full text in PMC Similar studies

Select item 20005133412.

DNA replication-timing boundaries separate stable chromosome domains with cell-type-specific functions

(Submitter supplied) Eukaryotic chromosomes replicate in a temporal order known as the replication-timing program. In mammals, replication timing is cell type-specific with at least half the genome switching replication timing during development, primarily in units of 400-800 kilobases ('replication domains;), whose positions are preserved in different cell types, conserved between species, and appear to confine long-range effects of chromosome rearrangements. more...

Organism:: Homo sapiens; Mus musculus

Type:: Other

25 related Platforms
993 Samples

Download data: BAM, BED, BIGWIG, BROADPEAK, NARROWPEAK, PAIR, TSV, TXT

Series

Accession:: GSE51334

ID:: 200051334

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004734513.

Gene expression profiling to recognize specific features of (non-) genotoxic carcinogens

(Submitter supplied) The current test strategy for carcinogenicity is generally based on in vitro and in vivo genotoxicity assays. Non-genotoxic carcinogens (NGTXC) are negative for genotoxicity and go undetected. Therefore, alternative tests to detect these chemicals are urgently needed. NGTXC act through different modes of action, which complicates the development of such assays. We have demonstrated recently in primary mouse hepatocytes that some, but certainly not all, NGTXC can be categorized according to their mode of action based on feature detection at a gene expression level (Schaap et al. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL17198
88 Samples

Download data: CEL

Series

Accession:: GSE47345

ID:: 200047345

Select item 20005992714.

Drug Matrix Data - CodeLink Arrays

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platforms:: GPL5425 GPL5426 GPL5424
12921 Samples

Download data: TXT

Series

Accession:: GSE59927

ID:: 200059927

Analyze with GEO2R

Select item 20005992315.

Exposure of rat to a variety of toxicants, liver assayed by Codelink microarray

(Submitter supplied) DrugMatrix is a comprehensive rat toxicogenomics database and analysis tool developed to facilitate the integration of toxicogenomics into hazard assessment. Using the whole genome and a diverse set of compounds allows a comprehensive view of most pharmacological and toxicological questions and is applicable to other situations such as disease and development.

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platforms:: GPL5426 GPL5425 GPL5424
5265 Samples

Download data: TXT

Series

Accession:: GSE59923

ID:: 200059923

Analyze with GEO2R

Select item 20005991316.

Exposure of rat to a variety of toxicants, kidney assayed by CodeLink microarray

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platforms:: GPL5425 GPL5424 GPL5426
2862 Samples

Download data: TXT

Series

Accession:: GSE59913

ID:: 200059913

Analyze with GEO2R

Select item 20005989417.

Exposure of rat to a variety of toxicants, bone marrow assayed by CodeLink microarray

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platforms:: GPL5426 GPL5425
983 Samples

Download data: TXT

Series

Accession:: GSE59894

ID:: 200059894

Analyze with GEO2R

Select item 20005782218.

Drug Matrix Data - Affymetrix Arrays

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL1355
5587 Samples

Download data: CEL

Series

Accession:: GSE57822

ID:: 200057822

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005781519.

Exposure of rat to a variety of toxicants, liver assayed by Affymetrix microarray

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL1355
2218 Samples

Download data: CEL

Series

Accession:: GSE57815

ID:: 200057815

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004069920.

CpG Methylation by Methyl 450K Bead Arrays from ENCODE/HAIB

(Submitter supplied) This data was generated by ENCODE. If you have questions about the data, contact the submitting laboratory directly (Florencia Pauli mailto:fpauli@hudsonalpha.org). If you have questions about the Genome Browser track associated with this data, contact ENCODE (mailto:genome@soe.ucsc.edu). This track is produced as part of the ENCODE project. The track displays the methylation status of specific CpG dinucleotides in the given cell types as identified by the Illumina Infinium Human Methylation 450 Bead Array platform (http://www.illumina.com/products/methylation_450_beadchip_kits.ilmn). more...

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL13534
62 Samples

Download data: IDAT

Series

Accession:: GSE40699

ID:: 200040699

ENCODE

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