TABLE 37.3.

Examples of glycan receptors for bacterial toxins

MicroorganismToxinGlycan-receptor specificitySite of infection
Bacillus thuringiensis crystal toxinsGalβ1-3/6Galα/β1-3(±Glcβ1-6) GalNAcβ GlcNAcβ1-3Manβ1-4 GlcβCerintestinal epithelium of insects/nematodes
Clostridium botulinum botulinum toxins (A–E)gangliosides GT1b and GQ1bnerve membrane
Clostridium difficile toxin AGalNAcβ1-3Galβ1-4GlcNAcβ1-3 Galβ1-4GlcβCerlarge intestine
Clostridium tetani tetanus toxinganglioside GT1bnerve membrane
Escherichia coli heat-labile toxinGM1intestine
Shigella dysenteriae Shiga toxinGalα1-4GalβCer,; Galα1-4Galβ1-4 GlcβCerlarge intestine
Vibrio cholerae cholera toxinGM1small intestine

Gangliosides are defined using the Svennerholm nomenclature (see Chapter 11).

Cer, Ceramide.

From: Chapter 37, Microbial Lectins: Hemagglutinins, Adhesins, and Toxins

Cover of Essentials of Glycobiology
Essentials of Glycobiology [Internet]. 4th edition.
Varki A, Cummings RD, Esko JD, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2022.
Copyright © 2022 The Consortium of Glycobiology Editors, La Jolla, California; published by Cold Spring Harbor Laboratory Press; doi:10.1101/glycobiology.4e.37. All rights reserved.

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