Table 8-2Intermediate Filament (IF) Proteins of the Nervous System

IF typeSubunitCell type
Type IIIVimentinNeural and glial precursors
GFAPAstrocytes, some Schwann cells
PeripherinSubset of neurons, particularly in PNS, may coassemble with NFH/NFM/NFL
DesminSmooth muscle cells in vasculature
Type IVNFHMost neurons, most abundant in large neurons
NFM
NFL
α-InternexinSubset of neurons, particularly parallel fibers in cerebellum, may also coassemble with NFH/NFM/NFL
Type IV?NestinNeuroectodermal precursors in developing brain

GFAP, glial fibrillary acidic protein; NFH, NFM and NFL, neurofilaments of high, medium and low molecular weight, respectively.

From: Molecular Components of the Neuronal Cytoskeleton

Cover of Basic Neurochemistry
Basic Neurochemistry: Molecular, Cellular and Medical Aspects. 6th edition.
Siegel GJ, Agranoff BW, Albers RW, et al., editors.
Philadelphia: Lippincott-Raven; 1999.
Copyright © 1999, American Society for Neurochemistry.

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