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Rational Design of PI3K-alpha Inhibitors that Exhibit Selectivity Over the PI3K-beta Isoform[TRANSFERASE/TRANSFERASE INHIBITOR]
View in iCn3D Similar StructuresProteinsConserved DomainsPubChem Compound
Discovery of GDC-0980: a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor for the Treatment of Cancer[TRANSFER...
View in iCn3D Similar StructuresPubMedProteinsConserved DomainsPubChem Compound
Fragment based discovery of a novel and selective PI3 Kinase inhibitor[TRANSFERASE]
Fragment Bound to PI3Kinase gamma[TRANSFERASE]
Structure-based design of thienobenzoxepin inhibitors of PI3-Kinase[TRANSFERASE/TRANSFERASE INHIBITOR]
Structure-based design of thienobenzoxepin inhibitors of PI3- kinase[TRANSFERASE/TRANSFERASE INHIBITOR]
Crystal structure of PI3K-gamma in complex with a quinoline inhibitor[TRANSFERASE/TRANSFERASE INHIBITOR]
Crystal structure of human PI3K-gamma in complex with CH5039699[Transferase/Transferase inhibitor]
Crystal structure of human PI3K-gamma in complex with CH5108134[Transferase/Transferase inhibitor]
Crystal structure of human PI3K-gamma in complex with CH5132799[Transferase/Transferase inhibitor]
Crystal structure of PI3K-gamma in complex with benzothiazole 82[TRANSFERASE/TRANSFERASE INHIBITOR]
Crystal structure of PI3K-gamma in complex with benzothiazole 1[TRANSFERASE/TRANSFERASE INHIBITOR]
Crystal structure of PI3K-gamma in complex with triazine-benzimidazole 32[TRANSFERASE/TRANSFERASE INHIBITOR]
Crystal structure of PI3K-gamma in complex with triazine-benzimidazole 1[TRANSFERASE/TRANSFERASE INHIBITOR]
Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors[TRANSFERASE/TRANSFERASE INHIBITOR]
4-Methylpteridineones as Orally Active and Selective PI3K/mTOR Dual Inhibitors[TRANSFERASE/TRANSFERASE INHIBITOR]
Structure of Pi3K gamma with a potent inhibitor: GSK2126458[TRANSFERASE]
Discovery of (thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer[TRANSFERASE]
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