7W3I: Structure of USP14-bound human 26S proteasome in substrate-inhibited state SB_USP14

PDB ID: 7W3IDownload
MMDB ID: 215614
PDB Deposition Date: 2021/11/25
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 3.5  Å
Source Organism:
Similar Structures:
Biological Unit for 7W3I: 48-meric; determined by author
Molecular Components in 7W3I
Label Count Molecule
Proteins (48 molecules)
1
Ubiquitin Carboxyl-terminal Hydrolase 14
(Gene symbol: USP14)
Molecule annotation
1
26S Protease Regulatory Subunit 7
(Gene symbol: PSMC2)
Molecule annotation
1
26S Protease Regulatory Subunit 4
(Gene symbol: PSMC1)
Molecule annotation
1
Isoform 2 of 26S Proteasome Regulatory Subunit 8
(Gene symbol: PSMC5)
Molecule annotation
1
26S Protease Regulatory Subunit 6B
(Gene symbol: PSMC4)
Molecule annotation
1
26S Proteasome Regulatory Subunit 10B
(Gene symbol: PSMC6)
Molecule annotation
1
26S Protease Regulatory Subunit 6A
(Gene symbol: PSMC3)
Molecule annotation
2
Proteasome Subunit Alpha Type-6
(Gene symbol: PSMA6)
Molecule annotation
2
Proteasome Subunit Alpha Type-2
(Gene symbol: PSMA2)
Molecule annotation
2
Proteasome Subunit Alpha Type-4
(Gene symbol: PSMA4)
Molecule annotation
2
Proteasome Subunit Alpha Type-7
(Gene symbol: PSMA7)
Molecule annotation
2
Proteasome Subunit Alpha Type-5
(Gene symbol: PSMA5)
Molecule annotation
2
Isoform Long of Proteasome Subunit Alpha Type-1
(Gene symbol: PSMA1)
Molecule annotation
2
Proteasome Subunit Alpha Type-3
(Gene symbol: PSMA3)
Molecule annotation
2
Proteasome Subunit Beta Type-6
(Gene symbol: PSMB6)
Molecule annotation
2
Proteasome Subunit Beta Type-7
(Gene symbol: PSMB7)
Molecule annotation
2
Proteasome Subunit Beta Type-3
(Gene symbol: PSMB3)
Molecule annotation
2
Proteasome Subunit Beta Type-2
(Gene symbol: PSMB2)
Molecule annotation
2
Proteasome Subunit Beta Type-5
(Gene symbol: PSMB5)
Molecule annotation
2
Proteasome Subunit Beta Type-1
(Gene symbol: PSMB1)
Molecule annotation
2
Proteasome Subunit Beta Type-4
(Gene symbol: PSMB4)
Molecule annotation
1
Ubiquitin
(Gene symbol: UBB)
Molecule annotation
1
26S Proteasome Non-atpase Regulatory Subunit 1
(Gene symbol: PSMD1)
Molecule annotation
1
26S Proteasome Non-atpase Regulatory Subunit 3
(Gene symbol: PSMD3)
Molecule annotation
1
26S Proteasome Non-atpase Regulatory Subunit 12
(Gene symbol: PSMD12)
Molecule annotation
1
26S Proteasome Non-atpase Regulatory Subunit 11
(Gene symbol: PSMD11)
Molecule annotation
1
26S Proteasome Non-atpase Regulatory Subunit 6
(Gene symbol: PSMD6)
Molecule annotation
1
26S Proteasome Non-atpase Regulatory Subunit 7
(Gene symbol: PSMD7)
Molecule annotation
1
26S Proteasome Non-atpase Regulatory Subunit 13
(Gene symbol: PSMD13)
Molecule annotation
1
26S Proteasome Non-atpase Regulatory Subunit 4
(Gene symbol: PSMD4)
Molecule annotation
1
26S Proteasome Non-atpase Regulatory Subunit 14
(Gene symbol: PSMD14)
Molecule annotation
1
26S Proteasome Non-atpase Regulatory Subunit 8
(Gene symbol: PSMD8)
Molecule annotation
1
26S Proteasome Non-atpase Regulatory Subunit 2
(Gene symbol: PSMD2)
Molecule annotation
1
26S Proteasome Complex Subunit Dss1
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
4
ADENOSINE-5'-TRIPHOSPHATEADENOSINE-5'-TRIPHOSPHATE
2
2
ADENOSINE-5'-DIPHOSPHATEADENOSINE-5'-DIPHOSPHATE
3
1
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303