2ZIS: Crystal Structure of rat protein farnesyltransferase complexed with a bezoruran inhibitor and FPP

PDB ID: 2ZISDownload
MMDB ID: 69787
PDB Deposition Date: 2008/2/22
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.6  Å
Source Organism:
Similar Structures:
Biological Unit for 2ZIS: dimeric; determined by author and by software (PISA)
Molecular Components in 2ZIS
Label Count Molecule
Proteins (2 molecules)
1
Protein Farnesyltransferase Subunit Alpha
(Gene symbol: Fnta)
Molecule annotation
1
Protein Farnesyltransferase Subunit Beta
(Gene symbol: Fntb)
Molecule annotation
Chemicals and Non-standard biopolymers (11 molecules)
1
2
ACETIC ACIDACETIC ACID
2
1
ZINC IONZINC ION
3
1
FARNESYL DIPHOSPHATEFARNESYL DIPHOSPHATE
4
1
3-{2-[(S)-(4-cyanophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl]-5-nitro-1-benzofuran-7-yl}benzonitrile3-{2-[(S)-(4-cyanophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl]-5-nitro-1-benzofuran-7-yl}benzonitrile
5
3
GLYCEROLGLYCEROL
6
3
Molecule information is not available.
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303