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Biotechnology Information

5Z56: cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom

PDB ID:

5Z56 Download

MMDB ID:

171437

PDB Deposition Date:

2018/1/17

Updated in MMDB:

2022/11

Experimental Method:

electron microscopy

Resolution:

5.1 Å

Source Organism:

unidentified adenovirus▼

Taxonomy	Molecule
unidentified adenovirus	G
Homo sapiens	A, B, C, D, E, a, b, c, d, f, e, g, F, H, h, i, j, k, m, l, n, o, p, w, u, v, 1, 2, 3, 4, 5, 6, 7, J , L, q, r, s, t, K, I, Q, M, N, O, P, R, S, T, U, V, W, X, Y, Z, z, x, y

Similar Structures:

Biological Unit for 5Z56: 59-meric; determined by author

Molecular Components in 5Z56
Label	Count	Molecule
Proteins (55 molecules)
A	1	Pre-mrna-processing-splicing Factor 8
C	1	116 KDA U5 Small Nuclear Ribonucleoprotein Component
D	1	U5 Small Nuclear Ribonucleoprotein 200 KDA Helicase
E	1	U5 Small Nuclear Ribonucleoprotein 40 KDA Protein
a h	2	Small Nuclear Ribonucleoprotein SM D3
b i	2	Small Nuclear Ribonucleoprotein-associated Proteins B and B'
c j	2	Small Nuclear Ribonucleoprotein SM D1
d k	2	Small Nuclear Ribonucleoprotein SM D2
f m	2	Small Nuclear Ribonucleoprotein F
e l	2	Small Nuclear Ribonucleoprotein E
g n	2	Small Nuclear Ribonucleoprotein G
o	1	U2 Small Nuclear Ribonucleoprotein A'
p	1	U2 Small Nuclear Ribonucleoprotein B''
w	1	Splicing Factor 3A Subunit 3
u	1	Splicing Factor 3A Subunit 1
v	1	Splicing Factor 3A Subunit 2
1	1	Splicing Factor 3B Subunit 1
2	1	Splicing Factor 3B Subunit 2
3	1	Splicing Factor 3B Subunit 3
4	1	Splicing Factor 3B Subunit 4
5	1	Splicing Factor 3B Subunit 6
6	1	PHD Finger-like Domain-containing Protein 5A
7	1	Splicing Factor 3B Subunit 5
J	1	Crooked Neck-like Protein 1
L	1	Cell Division Cycle 5-like Protein
q r s t	4	Pre-mrna-processing Factor 19
K	1	Pre-mrna-splicing Factor Spf27
I	1	Pre-mrna-splicing Factor Syf1
Q	1	Intron-binding Protein Aquarius
M	1	Ring Finger Protein 113a
N	1	Protein Bud31 Homolog
O	1	Pre-mrna-splicing Factor Rbm22
P	1	Spliceosome-associated Protein Cwc15 Homolog
R	1	Skip
S	1	Peptidyl-prolyl Cis-trans Isomerase-like 1
T	1	Pleiotropic Regulator 1
U	1	Serine/arginine Repetitive Matrix Protein 2
V	1	Pre-mrna-splicing Factor Cwc22 Homolog
W	1	Pre-mrna-processing Factor 17
X	1	Smad Nuclear-interacting Protein 1
Y	1	RNA-binding Motif Protein, X-linked 2
Z	1	Bud13 Homolog
z	1	Peptidyl-prolyl Cis-trans Isomerase Cwc27 Homolog
x	1	Putative Pre-mrna-splicing Factor Atp-dependent RNA Helicase Dhx16
y	1	Peptidyl-prolyl Cis-trans Isomerase E
Nucleotides(4 molecules)
B	1	U5 Snrna
F	1	U6 Snrna
G	1	Pre-mrna
H	1	U2 Snrna
Chemicals and Non-standard biopolymers (21 molecules)
1	1	INOSITOL HEXAKISPHOSPHATE (Link to PubChem not yet available)
2	1	GUANOSINE-5'-TRIPHOSPHATE (Link to PubChem not yet available)
3	6	MAGNESIUM ION (Link to PubChem not yet available)
4	13	ZINC ION (Link to PubChem not yet available)

* Click molecule labels to explore molecular sequence information.

Citing MMDB

Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303