5WG6: Human Polycomb Repressive Complex 2 in complex with GSK126 inhibitor

PDB ID: 5WG6Download
MMDB ID: 163737
PDB Deposition Date: 2017/7/13
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 3.901  Å
Source Organism:
Similar Structures:
Biological Unit for 5WG6: dimeric; determined by author and by software (PISA)
Molecular Components in 5WG6
Label Count Molecule
Proteins (2 molecules)
1
Histone-lysine N-methyltransferase Ezh2,polycomb Protein Suz12 (E.c.2.1.1.43) Chimera
(Gene symbol: SUZ12)
Molecule annotation
1
Polycomb Protein EED
(Gene symbol: EED)
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
8
ZINC IONZINC ION
2
1
1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-indole-4-carboxamide1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-indole-4-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303