4W2R: Structure of Hs/AcPRC2 in complex with 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one

PDB ID: 4W2RDownload
MMDB ID: 157658
PDB Deposition Date: 2017/9/25
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.81  Å
Source Organism:
Anolis carolinensis▼
Similar Structures:
Biological Unit for 4W2R: trimeric; determined by author and by software (PISA)
Molecular Components in 4W2R
Label Count Molecule
Proteins (3 molecules)
1
Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit
Molecule annotation
1
Polycomb Protein EED
Molecule annotation
1
Polycomb Protein Suz12
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
7
ZINC IONZINC ION
2
1
5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303