4GL9: Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and fragment of GP130 intracellular domain

PDB ID: 4GL9Download
MMDB ID: 108160
PDB Deposition Date: 2012/8/14
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 3.9  Å
Source Organism:
Similar Structures:
Biological Unit for 4GL9: trimeric; determined by author and by software (PISA)
Molecular Components in 4GL9
Label Count Molecule
Proteins (3 molecules)
1
Tyrosine-protein Kinase
(Gene symbol: Jak2)
Molecule annotation
1
Interleukin-6 Receptor Subunit Beta
(Gene symbol: Il6st)
Molecule annotation
1
Suppressor of Cytokine Signaling 3,suppressor of Cytokine Signaling 3,suppressor of Cytokine Signaling 3,suppressor of Cytokine Signaling 3
(Gene symbol: Socs3)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303