CASP8 caspase 8 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CASP8provided by HGNC
Official Full Name: caspase 8provided by HGNC
Primary source: HGNC:HGNC:1509
See related: Ensembl:ENSG00000064012 MIM:601763; AllianceGenome:HGNC:1509
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8
Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
Expression: Broad expression in bone marrow (RPKM 26.3), lymph node (RPKM 15.2) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q33.1

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (201233463..201287711)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (201716914..201768369)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (202098186..202152432)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Investigation of the association between the CASP8rs1045485 and SOD2 rs4880 single nucleotide polymorphisms (SNPs) with breast cancer.
Title: Investigation of the association between the CASP8rs1045485 and SOD2 rs4880 single nucleotide polymorphisms (SNPs) with breast cancer.
NBR1-mediated autophagic degradation of caspase 8 protects vascular endothelial cells against arsenite-induced apoptotic cell death.
Title: NBR1-mediated autophagic degradation of caspase 8 protects vascular endothelial cells against arsenite-induced apoptotic cell death.
Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis.
Title: Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis.
Role for Caspase-8 in the Release of IL-1beta and Active Caspase-1 from Viable Human Monocytes during Toxoplasma gondii Infection.
Title: Role for Caspase-8 in the Release of IL-1β and Active Caspase-1 from Viable Human Monocytes during Toxoplasma gondii Infection.
TNF and IFNgamma-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression.
Title: TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression.
Multidimensional Analysis of PANoptosis-Related Molecule CASP8: Prognostic Significance, Immune Microenvironment Effect, and Therapeutic Implications in Hepatocellular Carcinoma.
Title: Multidimensional Analysis of PANoptosis-Related Molecule CASP8: Prognostic Significance, Immune Microenvironment Effect, and Therapeutic Implications in Hepatocellular Carcinoma.
The role of caspase-8 in inflammatory signalling and pyroptotic cell death.
Title: The role of caspase-8 in inflammatory signalling and pyroptotic cell death.
Caspase-8 activation by cigarette smoke induces pro-inflammatory cell death of human macrophages exposed to lipopolysaccharide.
Title: Caspase-8 activation by cigarette smoke induces pro-inflammatory cell death of human macrophages exposed to lipopolysaccharide.
Circ_0004535/miR-1827/CASP8 network involved in type 2 diabetes mellitus with nonalcoholic fatty liver disease.
Title: Circ_0004535/miR-1827/CASP8 network involved in type 2 diabetes mellitus with nonalcoholic fatty liver disease.
Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation.
Title: Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation.

Submit: New GeneRIF Correction See all GeneRIFs (609)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Autoimmune lymphoproliferative syndrome type 2B MedGen: C1846545 OMIM: 607271 GeneReviews: Not available	Compare labs
Familial cancer of breast MedGen: C0346153 OMIM: 114480 GeneReviews: BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer	Compare labs
Hepatocellular carcinoma MedGen: C2239176 OMIM: 114550 GeneReviews: Not available	Compare labs
Lung cancer MedGen: C0242379 OMIM: 211980 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Genetics of rheumatoid arthritis contributes to biology and drug discovery. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies three new melanoma susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120-treated vaginal epithelial cells show downregulation of caspase 8 (CASP8, apoptosis-related cysteine peptidase) expression as compared to untreated control	PubMed
	env	Treatment of HIV-1 Env-pseudotyped virus-infected MDM cells with both soluble TRAIL and an agonistic anti-DR5 antibody AD5-10 induces activation of caspase-3, -8, and -9	PubMed
	env	HIV-1 gp120-induced neuron apoptosis requires the upregulation of the death receptor Fas and its associated death proteins, FADD and CASP8	PubMed
	env	Caspase 8 proteolytic target protein Bid is cleaved and undergoes mitochondrial translocation in gp120-treated p53 expression neurons	PubMed
	env	HIV-1 gp120-mediated activation of caspase 8 occurs in a p53 independent manner, while HIV-1 gp120-mediated activation of caspase 3 requires p53	PubMed
	env	Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9	PubMed
Envelope transmembrane glycoprotein gp41	env	Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9	PubMed
Nef	nef	Stable expression of HIV-1 Nef in Jurkat T cells confers resistance to Fas-mediated apoptosis through inactivation of caspase-3 and caspase-8	PubMed
Tat	tat	FasL-induced activation of caspase-3 and -8 proteins is inhibited in HIV-1 Tat101-expressing Jurkat cells	PubMed
	tat	Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides upregulate gene expression of caspase 8, apoptosis-related cysteine protease (CASP8) in U-937 macrophages	PubMed
	tat	HIV-1 Tat induces apoptosis and increases sensitivity to apoptotic signals by upregulating FLICE/Caspase-8	PubMed
Vpr	vpr	HIV-1 Vpr-mediated apoptosis and mitochondrial depolarization are dependent on CASP8 (caspase 8) activation in THP-1 and monocytes	PubMed
	vpr	HIV-1 Vpr-induced caspase-8 activation causes cleavage of BID to tBID through ERK activation	PubMed
	vpr	HIV-1 Vpr induces apoptosis through caspase activation and caspase 8 has been specifically demonstrated in one study to be activated during this process, however in other studies it was not activated	PubMed
Vpu	vpu	Caspase-8 and caspase-3 activity are required for HIV-1 Vpu-induced cleavage of IRF3 and HIV-1 infection also induces caspase-mediated IRF3 cleavage	PubMed
retropepsin	gag-pol	HIV-1 Protease cleaves procaspase 8 between amino acids 355 and 356 and generates casp8p41 protein in cells. Casp8p41 is produced in HIV-1-infected cells and colocalizes with dying cells	PubMed
	gag-pol	HIV-1 protease directly cleaves and activates procaspase 8 in T cells, which is associated with cleavage of BID, mitochondrial release of cytochrome c, activation of the downstream caspases 9 and 3, and cleavage of DFF and PARP	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

RH70951 (e-PCR)
- UniSTS:19740

PMC156606P1 (e-PCR)
- UniSTS:271408

D8S2278 (e-PCR)
- UniSTS:473906

PMC230316P2 (e-PCR)
- UniSTS:272180

RH70497 (e-PCR)
- UniSTS:83037

D2S1853 (e-PCR)
- UniSTS:4703

G29514 (e-PCR)
- UniSTS:75140

RH15884 (e-PCR)
- UniSTS:1671

A008P44 (e-PCR)
- UniSTS:14752

RH36454 (e-PCR)
- UniSTS:49624

GDB:631813 (e-PCR)
- UniSTS:158430

RH78960 (e-PCR)
- UniSTS:4072

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity	TAS Traceable Author Statement more info
enables cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
enables cysteine-type peptidase activity	TAS Traceable Author Statement more info	PubMed
enables death effector domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables death receptor binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell activation	TAS Traceable Author Statement more info	PubMed
involved_in T cell activation	TAS Traceable Author Statement more info	PubMed
involved_in TRAIL-activated apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in activation of cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic signaling pathway	TAS Traceable Author Statement more info
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
involved_in execution phase of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in execution phase of apoptosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IBA Inferred from Biological aspect of Ancestor more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IDA Inferred from Direct Assay more info	PubMed
involved_in heart development	ISS Inferred from Sequence or Structural Similarity more info
involved_in macrophage differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in macrophage differentiation	TAS Traceable Author Statement more info	PubMed
involved_in natural killer cell activation	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of necroptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of necroptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macrophage differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in protein maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis involved in protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis involved in protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in pyroptotic inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of tumor necrosis factor-mediated signaling pathway	TAS Traceable Author Statement more info
involved_in response to cobalt ion	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in response to tumor necrosis factor	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in self proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in syncytiotrophoblast cell differentiation involved in labyrinthine layer development	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of CD95 death-inducing signaling complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CD95 death-inducing signaling complex	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
part_of death-inducing signaling complex	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	TAS Traceable Author Statement more info
located_in mitochondrion	TAS Traceable Author Statement more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of ripoptosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: caspase-8

Names: FADD-homologous ICE/CED-3-like protease; FADD-like ICE; ICE-like apoptotic protease 5; MACH-alpha-1/2/3 protein; MACH-beta-1/2/3/4 protein; MORT1-associated ced-3 homolog; apoptotic cysteine protease; apoptotic protease Mch-5; caspase 8, apoptosis-related cysteine peptidase; caspase 8, apoptosis-related cysteine protease

NP_001073593.1

EC 3.4.22.61

NP_001073594.1

EC 3.4.22.61

NP_001219.2

EC 3.4.22.61

NP_001358980.1

EC 3.4.22.61

NP_001387571.1

EC 3.4.22.61

NP_001387574.1

EC 3.4.22.61

NP_001387577.1

EC 3.4.22.61

NP_001387580.1

EC 3.4.22.61

NP_001387582.1

EC 3.4.22.61

NP_001387583.1

EC 3.4.22.61

NP_001387584.1

EC 3.4.22.61

NP_001387585.1

EC 3.4.22.61

NP_001387586.1

EC 3.4.22.61

NP_001387587.1

EC 3.4.22.61

NP_001387588.1

EC 3.4.22.61

NP_001387589.1

EC 3.4.22.61

NP_001387590.1

EC 3.4.22.61

NP_001387591.1

EC 3.4.22.61

NP_001387592.1

EC 3.4.22.61

NP_001387593.1

EC 3.4.22.61

NP_001387594.1

EC 3.4.22.61

NP_001387595.1

EC 3.4.22.61

NP_001387596.1

EC 3.4.22.61

NP_001387597.1

EC 3.4.22.61

NP_001387598.1

EC 3.4.22.61

NP_001387599.1

EC 3.4.22.61

NP_001387600.1

EC 3.4.22.61

NP_001387601.1

EC 3.4.22.61

NP_001387602.1

EC 3.4.22.61

NP_001387603.1

EC 3.4.22.61

NP_001387604.1

EC 3.4.22.61

NP_001387605.1

EC 3.4.22.61

NP_001387606.1

EC 3.4.22.61

NP_001387607.1

EC 3.4.22.61

NP_001387608.1

EC 3.4.22.61

NP_001387609.1

EC 3.4.22.61

NP_001387679.1

EC 3.4.22.61

NP_001387680.1

EC 3.4.22.61

NP_203519.1

EC 3.4.22.61

NP_203520.1

EC 3.4.22.61

XP_005246950.1

EC 3.4.22.61

XP_011510271.1

EC 3.4.22.61

XP_047301915.1

EC 3.4.22.61

XP_047301916.1

EC 3.4.22.61

XP_047301917.1

EC 3.4.22.61

XP_054200090.1

EC 3.4.22.61

XP_054200091.1

EC 3.4.22.61

XP_054200092.1

EC 3.4.22.61

XP_054200093.1

EC 3.4.22.61

XP_054200094.1

EC 3.4.22.61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007497.1 RefSeqGene

Range

4986..59254

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_34

mRNA and Protein(s)

NM_001080124.2 → NP_001073593.1 caspase-8 isoform 3

See identical proteins and their annotated locations for NP_001073593.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) includes different segments in the 5' UTR and lacks an alternate in-frame segment in the coding region, compared to variant 7. Variants 3 and 7 both encode isoform 3, which is shorter than isoform 7. Isoform 3 has also been labelled as Alpha-2 or MCH5-beta.

Source sequence(s)

AC007256, AF422927, AI351872

Consensus CDS

CCDS2343.1

UniProtKB/TrEMBL

B5BU46

Related

ENSP00000376091.2, ENST00000392263.6

Conserved Domains (3) summary

cd00032
Location:210 → 462

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 180

DD; Death Domain Superfamily of protein-protein interaction domains
NM_001080125.2 → NP_001073594.1 caspase-8 isoform 7 precursor

Status: REVIEWED

Source sequence(s)

AC007256, AF422927, AI351872, X98172

Consensus CDS

CCDS42798.1

UniProtKB/TrEMBL

B5BU46

Related

ENSP00000351273.4, ENST00000358485.8

Conserved Domains (3) summary

cd00032
Location:284 → 536

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:62 → 143

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:157 → 239

DD; Death Domain Superfamily of protein-protein interaction domains
NM_001228.5 → NP_001219.2 caspase-8 isoform 1 precursor

See identical proteins and their annotated locations for NP_001219.2

Status: REVIEWED

Description

Transcript Variant: This variant (1), also known as Alpha-4, has multiple differences in the 5' UTR and coding region, compared to variant 7. It encodes isoform 1 which is shorter than isoform 7.

Source sequence(s)

AC007256, AC007283

Consensus CDS

CCDS42799.1

UniProtKB/TrEMBL

B5BU46

Related

ENSP00000264275.5, ENST00000264275.9

Conserved Domains (3) summary

cd00032
Location:242 → 494

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:134 → 212

DD; Death Domain Superfamily of protein-protein interaction domains
NM_001372051.1 → NP_001358980.1 caspase-8 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC007256

Consensus CDS

CCDS2342.1

UniProtKB/Swiss-Prot

O14676, Q14790, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81

UniProtKB/TrEMBL

B5BU46

Related

ENSP00000501268.1, ENST00000673742.1

Conserved Domains (3) summary

cd00032
Location:225 → 477

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 180

DD; Death Domain Superfamily of protein-protein interaction domains
NM_001400642.1 → NP_001387571.1 caspase-8 isoform 8

Status: REVIEWED

Source sequence(s)

AC007256

Consensus CDS

CCDS92922.1

UniProtKB/TrEMBL

A0A8Q3SID9

Related

ENSP00000512381.1, ENST00000696085.1
NM_001400645.1 → NP_001387574.1 caspase-8 isoform 9

Status: REVIEWED

Source sequence(s)

AC007256
NM_001400648.1 → NP_001387577.1 caspase-8 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC007256, AC007283

Consensus CDS

CCDS2342.1

UniProtKB/Swiss-Prot

O14676, Q14790, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81
NM_001400651.1 → NP_001387580.1 caspase-8 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC007256, AC007283

Consensus CDS

CCDS2342.1

UniProtKB/Swiss-Prot

O14676, Q14790, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81

Related

ENSP00000512369.1, ENST00000696067.1
NM_001400653.1 → NP_001387582.1 caspase-8 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC007256

Consensus CDS

CCDS2342.1

UniProtKB/Swiss-Prot

O14676, Q14790, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81
NM_001400654.1 → NP_001387583.1 caspase-8 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC007256

Consensus CDS

CCDS2342.1

UniProtKB/Swiss-Prot

O14676, Q14790, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81
NM_001400655.1 → NP_001387584.1 caspase-8 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC007256

Consensus CDS

CCDS2342.1

UniProtKB/Swiss-Prot

O14676, Q14790, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81
NM_001400656.1 → NP_001387585.1 caspase-8 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC007256

Consensus CDS

CCDS2342.1

UniProtKB/Swiss-Prot

O14676, Q14790, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81

Related

ENSP00000397528.2, ENST00000413726.6
NM_001400657.1 → NP_001387586.1 caspase-8 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC007256, AC007283

Consensus CDS

CCDS2342.1

UniProtKB/Swiss-Prot

O14676, Q14790, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81

Related

ENSP00000396869.2, ENST00000440732.6
NM_001400658.1 → NP_001387587.1 caspase-8 isoform 3

Status: REVIEWED

Source sequence(s)

AC007256

Consensus CDS

CCDS2343.1

Related

ENSP00000512382.1, ENST00000696087.1
NM_001400659.1 → NP_001387588.1 caspase-8 isoform 3

Status: REVIEWED

Source sequence(s)

AC007256

Consensus CDS

CCDS2343.1

Related

ENSP00000512371.1, ENST00000696069.1
NM_001400660.1 → NP_001387589.1 caspase-8 isoform 3

Status: REVIEWED

Source sequence(s)

AC007256, AC007283

Consensus CDS

CCDS2343.1
NM_001400661.1 → NP_001387590.1 caspase-8 isoform 3

Status: REVIEWED

Source sequence(s)

AC007256, AC007283

Consensus CDS

CCDS2343.1
NM_001400662.1 → NP_001387591.1 caspase-8 isoform 3

Status: REVIEWED

Source sequence(s)

AC007256

Consensus CDS

CCDS2343.1
NM_001400663.1 → NP_001387592.1 caspase-8 isoform 3

Status: REVIEWED

Source sequence(s)

AC007256, AC007283

Consensus CDS

CCDS2343.1
NM_001400664.1 → NP_001387593.1 caspase-8 isoform 10

Status: REVIEWED

Source sequence(s)

AC007256
NM_001400665.1 → NP_001387594.1 caspase-8 isoform 11

Status: REVIEWED

Source sequence(s)

AC007256
NM_001400666.1 → NP_001387595.1 caspase-8 isoform 12

Status: REVIEWED

Source sequence(s)

AC007256
NM_001400667.1 → NP_001387596.1 caspase-8 isoform 13

Status: REVIEWED

Source sequence(s)

AC007256

Consensus CDS

CCDS92923.1

Related

ENSP00000394434.3, ENST00000444430.3
NM_001400668.1 → NP_001387597.1 caspase-8 isoform 13

Status: REVIEWED

Source sequence(s)

AC007256

Consensus CDS

CCDS92923.1
NM_001400669.1 → NP_001387598.1 caspase-8 isoform 14

Status: REVIEWED

Source sequence(s)

AC007256, AC007283

Related

ENSP00000391709.2, ENST00000450491.6
NM_001400670.1 → NP_001387599.1 caspase-8 isoform 15

Status: REVIEWED

Source sequence(s)

AC007256
NM_001400671.1 → NP_001387600.1 caspase-8 isoform 16

Status: REVIEWED

Source sequence(s)

AC007256
NM_001400672.1 → NP_001387601.1 caspase-8 isoform 16

Status: REVIEWED

Source sequence(s)

AC007256
NM_001400673.1 → NP_001387602.1 caspase-8 isoform 16

Status: REVIEWED

Source sequence(s)

AC007256
NM_001400674.1 → NP_001387603.1 caspase-8 isoform 17

Status: REVIEWED

Source sequence(s)

AC007256
NM_001400675.1 → NP_001387604.1 caspase-8 isoform 18

Status: REVIEWED

Source sequence(s)

AC007256
NM_001400676.1 → NP_001387605.1 caspase-8 isoform 18

Status: REVIEWED

Source sequence(s)

AC007256
NM_001400677.1 → NP_001387606.1 caspase-8 isoform 18

Status: REVIEWED

Source sequence(s)

AC007256, AC007283
NM_001400678.1 → NP_001387607.1 caspase-8 isoform 18

Status: REVIEWED

Source sequence(s)

AC007256
NM_001400679.1 → NP_001387608.1 caspase-8 isoform 5

Status: REVIEWED

Source sequence(s)

AC007256, AC007283

Consensus CDS

CCDS2345.1

Related

ENSP00000376087.3, ENST00000392258.7
NM_001400680.1 → NP_001387609.1 caspase-8 isoform 17

Status: REVIEWED

Source sequence(s)

AC007256, AC007283
NM_001400750.1 → NP_001387679.1 caspase-8 isoform 16

Status: REVIEWED

Source sequence(s)

AC007256
NM_001400751.1 → NP_001387680.1 caspase-8 isoform 18

Status: REVIEWED

Source sequence(s)

AC007256
NM_033355.4 → NP_203519.1 caspase-8 isoform 2 precursor

See identical proteins and their annotated locations for NP_203519.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) includes different segments in its 5' UTR and lacks a 5' coding region segment, compared to variant G. This results in translation at a downstream start codon, and the encoded protein (isoform 2) has a shorter N-terminus when it is compared to isoform 7.

Source sequence(s)

AC007256, AC007283

Consensus CDS

CCDS2342.1

UniProtKB/Swiss-Prot

O14676, Q14790, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81

UniProtKB/TrEMBL

B5BU46

Related

ENSP00000412523.2, ENST00000432109.6

Conserved Domains (3) summary

cd00032
Location:225 → 477

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 180

DD; Death Domain Superfamily of protein-protein interaction domains
NM_033356.4 → NP_203520.1 caspase-8 isoform 3

See identical proteins and their annotated locations for NP_203520.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) includes a different segment in the 5' UTR and lacks an alternate in-frame segment in the coding region, compared to variant 7. Variants 3 and 6 both encode isoform 3, which is shorter than isoform 7. Isoform 3 has also been labelled as Alpha-2 or MCH5-beta.

Source sequence(s)

AC007256, AI351872, AL601594, BC028223, X98173

Consensus CDS

CCDS2343.1

UniProtKB/TrEMBL

B5BU46

Related

ENSP00000325722.7, ENST00000323492.11

Conserved Domains (3) summary

cd00032
Location:210 → 462

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 180

DD; Death Domain Superfamily of protein-protein interaction domains

RNA

NR_111983.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (8) has an alternate splice site in the central region, compared to variant 7. This variant is represented as non-coding because use of the 5'-most expected translation start codon, as used in variant 7, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC007256, AF380342, BG236020, U60520
NR_174564.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007256
NR_174565.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007256, AC007283
NR_174581.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007256, AC007283
NR_174582.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007256, AC007283

Related

ENST00000490682.6
NR_174583.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007256, AC007283
NR_174584.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007256
NR_174585.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007256
NR_174586.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007256
NR_174588.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007256, AC007283
NR_174589.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007256
NR_174590.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007256, AC007283
NR_174591.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007256
NR_174592.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007256
NR_174593.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007256
NR_174594.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007256, AC007283
NR_174595.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007256
NR_174596.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007256
NR_174598.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007256, AC007283
NR_174599.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007256
NR_174600.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007256
NR_174601.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007256
NR_174602.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007256

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

201233463..201287711

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047445961.1 → XP_047301917.1 caspase-8 isoform X5
XM_047445959.1 → XP_047301915.1 caspase-8 isoform X1
XM_005246893.4 → XP_005246950.1 caspase-8 isoform X4

See identical proteins and their annotated locations for XP_005246950.1

Conserved Domains (2) summary

cd08333
Location:62 → 143

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:157 → 239

DD; Death Domain Superfamily of protein-protein interaction domains
XM_047445960.1 → XP_047301916.1 caspase-8 isoform X2
XM_011511969.3 → XP_011510271.1 caspase-8 isoform X3

UniProtKB/TrEMBL

C9JB29

Conserved Domains (2) summary

cd00032
Location:80 → 332

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cl14633
Location:1 → 35

DD; Death Domain Superfamily of protein-protein interaction domains

RNA

XR_007082538.1 RNA Sequence
XR_007082539.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060926.1 Alternate T2T-CHM13v2.0

Range

201716914..201768369

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054344119.1 → XP_054200094.1 caspase-8 isoform X7
XM_054344115.1 → XP_054200090.1 caspase-8 isoform X1
XM_054344118.1 → XP_054200093.1 caspase-8 isoform X6
XM_054344116.1 → XP_054200091.1 caspase-8 isoform X2
XM_054344117.1 → XP_054200092.1 caspase-8 isoform X3

RNA

XR_008486541.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_033357.2: Suppressed sequence

Description

NM_033357.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
NM_033358.4: Suppressed sequence

Description

NM_033358.4: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.