AP2 Integrase-type DNA-binding superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: AP2
Gene description: Integrase-type DNA-binding superfamily protein
Primary source: Araport:AT4G36920
Locus tag: AT4G36920
See related: TAIR:AT4G36920
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AP22.49; AP22_49; APETALA 2; AtAP2; FL1; FLO2; FLORAL HOMEOTIC PROTEIN APETALA 2; FLORAL MUTANT 2; FLOWER 1
Summary: Encodes a floral homeotic gene, a member of the AP2/EREBP (ethylene responsive element binding protein) class of transcription factors and is involved in the specification of floral organ identity, establishment of floral meristem identity, suppression of floral meristem indeterminancy, and development of the ovule and seed coat. AP2 also has a role in controlling seed mass. Dominant negative allele I28, revealed a function in meristem maintenance-mutant meristems are smaller than normal siblings. AP2 appears to act on the WUS-CLV pathway in an AG independent manner.
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Genomic context

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See AP2 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 11

Sequence:: Chromosome: 4; NC_003075.7 (17400610..17403469)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The APETALA2-MYBL2 module represses proanthocyanidin biosynthesis by affecting formation of the MBW complex in seeds of Arabidopsis thaliana.
Title: The APETALA2-MYBL2 module represses proanthocyanidin biosynthesis by affecting formation of the MBW complex in seeds of Arabidopsis thaliana.
Arrest, Senescence and Death of Shoot Apical Stem Cells in Arabidopsis thaliana.
Title: Arrest, Senescence and Death of Shoot Apical Stem Cells in Arabidopsis thaliana.
AtERF71/HRE2, an Arabidopsis AP2/ERF Transcription Factor Gene, Contains Both Positive and Negative Cis-Regulatory Elements in Its Promoter Region Involved in Hypoxia and Salt Stress Responses.
Title: AtERF71/HRE2, an Arabidopsis AP2/ERF Transcription Factor Gene, Contains Both Positive and Negative Cis-Regulatory Elements in Its Promoter Region Involved in Hypoxia and Salt Stress Responses.
The Evolution of euAPETALA2 Genes in Vascular Plants: From Plesiomorphic Roles in Sporangia to Acquired Functions in Ovules and Fruits.
Title: The Evolution of euAPETALA2 Genes in Vascular Plants: From Plesiomorphic Roles in Sporangia to Acquired Functions in Ovules and Fruits.
A phylogenetically conserved APETALA2/ETHYLENE RESPONSE FACTOR, ERF12, regulates Arabidopsis floral development.
Title: A phylogenetically conserved APETALA2/ETHYLENE RESPONSE FACTOR, ERF12, regulates Arabidopsis floral development.
AP2 is essential for plant growth under boron deficient conditions.
Title: Polar Localization of the Borate Exporter BOR1 Requires AP2-Dependent Endocytosis.
AP2 does not repress the transcription of AG in the inner two whorls, but instead counteracts AG activity.
Title: APETALA2 antagonizes the transcriptional activity of AGAMOUS in regulating floral stem cells in Arabidopsis thaliana.
AtFLO2 is strongly involved in regulation of translocation and transport of assimilates, and contributes greatly to quality control of the various processes involving substance supply or transfer, such as photoassimilation, leaf enlargement, yield of seeds in a silique and accumulation of seed storage compounds.
Title: Arabidopsis thaliana FLO2 is Involved in Efficiency of Photoassimilate Translocation, Which is Associated with Leaf Growth and Aging, Yield of Seeds and Seed Quality.
Data show that FRUITFULL (FUL), a MADS-box gene involved in flowering and fruit development, has a key role in promoting meristem arrest, directly and negatively regulates APETALA2 expression in the shoot apical meristem.
Title: Genetic control of meristem arrest and life span in Arabidopsis by a FRUITFULL-APETALA2 pathway.
APETALA2 Gene Promoter Is Bidirectional and Functions as a Pollen- and Ovule-Specific Promoter in the Reverse Orientation
Title: Promoter Trapping and Deletion Analysis Show Arabidopsis thaliana APETALA2 Gene Promoter Is Bidirectional and Functions as a Pollen- and Ovule-Specific Promoter in the Reverse Orientation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001204009.1

Supported by ESTs:

NM_119856.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within flower development	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within meristem maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant ovule development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within seed development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sexual reproduction	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within specification of floral organ identity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in specification of floral organ identity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: Integrase-type DNA-binding superfamily protein

NP_001190938.1

APETALA 2 (AP2); CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: target of early activation tagged (EAT) 3 (TAIR:AT5G67180.1).

NP_195410.1

APETALA 2 (AP2); CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: target of early activation tagged (EAT) 3 (TAIR:AT5G67180.1); Has 8542 Blast hits to 5152 proteins in 275 species: Archae - 0; Bacteria - 58; Metazoa - 3; Fungi - 0; Plants - 8374; Viruses - 7; Other Eukaryotes - 100 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

17400610..17403469

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001204009.1 → NP_001190938.1 Integrase-type DNA-binding superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190938.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P47927, Q8L7P9

UniProtKB/TrEMBL

A0A178UZG8, A0A5S9XZB0, A0A654FWH9

Conserved Domains (1) summary

smart00380
Location:223 → 286

AP2; DNA-binding domain in plant proteins such as APETALA2 and EREBPs
NM_119856.3 → NP_195410.1 Integrase-type DNA-binding superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_195410.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P47927, Q8L7P9

UniProtKB/TrEMBL

A0A178UZG8, A0A5S9XZB0, A0A654FWH9

Conserved Domains (1) summary

smart00380
Location:223 → 286

AP2; DNA-binding domain in plant proteins such as APETALA2 and EREBPs