AT3G60860 SEC7-like guanine nucleotide exchange family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: AT3G60860
Gene description: SEC7-like guanine nucleotide exchange family protein
Primary source: Araport:AT3G60860
Locus tag: AT3G60860
See related: TAIR:AT3G60860
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
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Genomic context

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See AT3G60860 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 11

Sequence:: Chromosome: 3; NC_003074.8 (22484397..22491935)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BEN3/BIG2 is an guanine nucleotide exchange factors for ADP ribosylation factor component, which confers brefeldin A sensitivity to the trans-Golgi Network/Early Endosome in Arabidopsis.[BEN3]
Title: BEN3/BIG2 ARF GEF is Involved in Brefeldin A-Sensitive Trafficking at the trans-Golgi Network/Early Endosome in Arabidopsis thaliana.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_115950.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi to plasma membrane protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ARF protein signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
colocalizes_with early endosome	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: SEC7-like guanine nucleotide exchange family protein

NP_191645.1

SEC7-like guanine nucleotide exchange family protein; FUNCTIONS IN: binding, ARF guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor activity; INVOLVED IN: regulation of ARF protein signal transduction; LOCATED IN: intracellular; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: SEC7-like (InterPro:IPR000904), Armadillo-type fold (InterPro:IPR016024), Protein of unknown function DUF1981, SEC7 associated (InterPro:IPR015403); BEST Arabidopsis thaliana protein match is: SEC7-like guanine nucleotide exchange family protein (TAIR:AT1G01960.1); Has 2962 Blast hits to 2694 proteins in 246 species: Archae - 0; Bacteria - 33; Metazoa - 1475; Fungi - 672; Plants - 315; Viruses - 0; Other Eukaryotes - 467 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

22484397..22491935

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_115950.4 → NP_191645.1 SEC7-like guanine nucleotide exchange family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_191645.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LZX8

UniProtKB/TrEMBL

A0A654FJM2

Conserved Domains (6) summary

PLN03076
Location:1 → 1793

PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional

pfam01369
Location:617 → 799

Sec7; Sec7 domain

pfam09324
Location:1166 → 1249

DUF1981; Domain of unknown function (DUF1981)

pfam12783
Location:345 → 499

Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

pfam16206
Location:1346 → 1421

Mon2_C; C-terminal region of Mon2 protein

pfam16213
Location:6 → 217

DCB; Dimerization and cyclophilin-binding domain of Mon2