TLR7 toll like receptor 7 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: TLR7provided by VGNC
Official Full Name: toll like receptor 7provided by VGNC
Primary source: VGNC:VGNC:52836
See related: Ensembl:ENSBTAG00000022161
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: X

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	X	NC_037357.1 (130768546..130786344, complement)

Chromosome X - NC_037357.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

On day 104 of pregnancy, mRNA expression of TLRs 3 and 8, as well as that of TLRs 7 and 9, was high in the spleen of fetuses from Neospora caninum-infected heifers. Gene expression levels of endosomal TLRs were also detectable in the placenta and the maternal caruncle from infected heifers, being TLRs 3, 7 and 8 particularly upregulated, mostly in the caruncle.
Title: Toll-like receptors 3, 7 and 8 are upregulated in the placental caruncle and fetal spleen of Neospora caninum experimentally infected cattle.
TLR7 stimulation of Bovine Viral Diarrhea Virus Type 2-infected monocyte-derived macrophages induced cytokine secretion, unlike results observed for other Toll-Like Receptors.
Title: Bovine Viral Diarrhea Virus Type 2 Impairs Macrophage Responsiveness to Toll-Like Receptor Ligation with the Exception of Toll-Like Receptor 7.
The results from this study demonstrate that expression of at least TLR3, TLR7 and TLR8 is stimulated upon bovine alpha-herpesvirus infection of the brain.
Title: Involvement of toll-like receptors 3 and 7/8 in the neuropathogenesis of bovine herpesvirus types 1 and 5.
Comparative sequence analysis revealed a total of 139 polymorphisms, which include single-nucleotide polymorphisms and insertion-deletion polymorphisms.
Title: Detection of polymorphisms in bovine toll-like receptors 3, 7, 8, and 9.

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General gene information

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Markers

TLR7 (e-PCR)
- UniSTS:506514

TLR7 (e-PCR)
- UniSTS:519397

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables pattern recognition receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info	PubMed
involved_in toll-like receptor 7 signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: toll-like receptor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033761.1 → NP_001028933.1 toll-like receptor 7

See identical proteins and their annotated locations for NP_001028933.1

Status: PROVISIONAL

Source sequence(s)

AY487802

UniProtKB/TrEMBL

A5H645, F5AVD9, Q3MNF2

Conserved Domains (4) summary

smart00255
Location:899 → 1044

TIR; Toll - interleukin 1 - resistance

cd00116
Location:628 → 768

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:505 → 527

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:505 → 563

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

Range

130768546..130786344 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015461802.3 → XP_015317288.1 toll-like receptor 7 isoform X1

UniProtKB/TrEMBL

A0A3Q1MK24, A1XC24

Conserved Domains (6) summary

TIGR00864
Location:754 → 838

PCC; polycystin cation channel protein

smart00255
Location:891 → 1036

TIR; Toll - interleukin 1 - resistance

sd00033
Location:497 → 519

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:66 → 139

LRR_8; Leucine rich repeat

cl26018
Location:108 → 307

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:246 → 785

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
XM_005228486.5 → XP_005228543.1 toll-like receptor 7 isoform X1

See identical proteins and their annotated locations for XP_005228543.1

UniProtKB/TrEMBL

A0A3Q1MK24, A1XC24

Related

ENSBTAP00000061744.1, ENSBTAT00000077162.2

Conserved Domains (6) summary

TIGR00864
Location:754 → 838

PCC; polycystin cation channel protein

smart00255
Location:891 → 1036

TIR; Toll - interleukin 1 - resistance

sd00033
Location:497 → 519

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:66 → 139

LRR_8; Leucine rich repeat

cl26018
Location:108 → 307

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:246 → 785

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
XM_015461803.3 → XP_015317289.1 toll-like receptor 7 isoform X2

UniProtKB/TrEMBL

A0A3Q1MK24, A0AAA9RUI2

Related

ENSBTAP00000093104.1, ENSBTAT00000118401.1

Conserved Domains (6) summary

TIGR00864
Location:750 → 834

PCC; polycystin cation channel protein

smart00255
Location:887 → 1032

TIR; Toll - interleukin 1 - resistance

sd00033
Location:493 → 515

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:62 → 135

LRR_8; Leucine rich repeat

cl26018
Location:104 → 303

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:242 → 781

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional