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Conserved domains on  [gi|529016127|ref|XP_005228543|]
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toll-like receptor 7 isoform X1 [Bos taurus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
498-786 2.90e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.53  E-value: 2.90e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  498 TLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNSISQTLNGSEFQPLVELKYLDFSNNRldllystAFEELHNLEVLDISSN 577
Cdd:COG4886    51 LLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGN 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  578 ShyfqsegITHMLNFTKNLKVLRKLMMNYNDIATstsrtmeseslqilefrgnhldilwrdgdnrYLKFFKNLLNLEELD 657
Cdd:COG4886   124 Q-------LTDLPEELANLTNLKELDLSNNQLTD-------------------------------LPEPLGNLTNLKSLD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  658 ISENSLSFLPLGVFDSmpPNLKTLSLAKNGLKSFSWErLQSLKNLETLDLSFNQLKTVPERLSNCSrSLKKLILKNNQIR 737
Cdd:COG4886   166 LSNNQLTDLPEELGNL--TNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEPLANLT-NLETLDLSNNQLT 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 529016127  738 CLTKyfLQGAFQLRHLDLSSNKIqviqkTSFPENV-LNNLNILFLHHNRF 786
Cdd:COG4886   242 DLPE--LGNLTNLEELDLSNNQL-----TDLPPLAnLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
120-326 1.55e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 1.55e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  120 PNSFSKLTYLKSLYLDGNQLLEIPqdlppslqllsleanniflimkENLTELANLEILYLGQNcyyrnpcnvSFTIEKDA 199
Cdd:COG4886   106 NEELSNLTNLESLDLSGNQLTDLP----------------------EELANLTNLKELDLSNN---------QLTDLPEP 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  200 FLNMRNLKLLSLKDNNISAVPTVLP--SSLTELYLYNNIITKIQEdDFNNLSQLQVLDLSGNcprcynvpfpctpcenns 277
Cdd:COG4886   155 LGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGN------------------ 215

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 529016127  278 PLQIDPNAFDALTELQVLRLHSNSLQHVPqrWFKNINKLKELDLSQNFL 326
Cdd:COG4886   216 QLTDLPEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL 262
TIR smart00255
Toll - interleukin 1 - resistance;
891-1036 1.51e-13

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 68.89  E-value: 1.51e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127    891 CYDAFIVYdtkdpAVTEWVLDELVAKLEDpREKCFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKI 970
Cdd:smart00255    1 EYDVFISY-----SGKEDVRNEFLSHLLE-KLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLD 74

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127    971 AFYLSHQRLMDEKVDVIILIFLEK----PLQKSKFLQLRKRlcgSSVLEWPTNPQAHpyFWQCLKNALAT 1036
Cdd:smart00255   75 ELVAALENALEEGGLRVIPIFYEVipsdVRKQPGKFRKVFK---KNYLKWPEDEKEQ--FWKKALYAVPS 139
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 364-577 3.11e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 49.40  E-value: 3.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  364 DAFSSLKKLKVLrikgYVFKelNSLNLFP-LHNLPNLEVLDLGTNFI-KIANLsifNQFKTLKFIDLSVNKISpsgdspe 441
Cdd:cd21340    18 DNLSLCKNLKVL----YLYD--NKITKIEnLEFLTNLTHLYLQNNQIeKIENL---ENLVNLKKLYLGGNRIS------- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  442 ggfcsnrrtSVEG-HGPQVLETLHYfrydEYARscrskskeppsfLPLnedcymyGQTLDLSRNNIFFIKPSdfqhlsfL 520
Cdd:cd21340    82 ---------VVEGlENLTNLEELHI----ENQR------------LPP-------GEKLTFDPRSLAALSNS-------L 122

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 529016127  521 KCLNLSGNSISqtlNGSEFQPLVELKYLDFSNNRLDLL--YSTAFEELHNLEVLDISSN 577
Cdd:cd21340   123 RVLNISGNNID---SLEPLAPLRNLEQLDASNNQISDLeeLLDLLSSWPSLRELDLTGN 178
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 754-838 1.23e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.70  E-value: 1.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127   754 DLSSNKIQVIQKTSFpeNVLNNLNILFLHHNRFLCNCDAVWFVWWVNHTEVTI--PYLAtdvTCMGPGAHKGQSVVSLDL 831
Cdd:TIGR00864    1 DISNNKISTIEEGIC--ANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqPEAA---LCAGPGALAGQPLLGIPL 75


                   ....*..
gi 529016127   832 YTCELDL 838
Cdd:TIGR00864   76 LDSGCDE 82
LRR_8 pfam13855
Leucine rich repeat;
66-139 6.31e-05

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 6.31e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 529016127    66 NATNLTLTINHIAGISPASFHRLDHLVEIDFRCNCVPVrlgpkdnvctkrlqIKPNSFSKLTYLKSLYLDGNQL 139
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--------------LSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
498-786 2.90e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.53  E-value: 2.90e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  498 TLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNSISQTLNGSEFQPLVELKYLDFSNNRldllystAFEELHNLEVLDISSN 577
Cdd:COG4886    51 LLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGN 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  578 ShyfqsegITHMLNFTKNLKVLRKLMMNYNDIATstsrtmeseslqilefrgnhldilwrdgdnrYLKFFKNLLNLEELD 657
Cdd:COG4886   124 Q-------LTDLPEELANLTNLKELDLSNNQLTD-------------------------------LPEPLGNLTNLKSLD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  658 ISENSLSFLPLGVFDSmpPNLKTLSLAKNGLKSFSWErLQSLKNLETLDLSFNQLKTVPERLSNCSrSLKKLILKNNQIR 737
Cdd:COG4886   166 LSNNQLTDLPEELGNL--TNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEPLANLT-NLETLDLSNNQLT 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 529016127  738 CLTKyfLQGAFQLRHLDLSSNKIqviqkTSFPENV-LNNLNILFLHHNRF 786
Cdd:COG4886   242 DLPE--LGNLTNLEELDLSNNQL-----TDLPPLAnLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
120-326 1.55e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 1.55e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  120 PNSFSKLTYLKSLYLDGNQLLEIPqdlppslqllsleanniflimkENLTELANLEILYLGQNcyyrnpcnvSFTIEKDA 199
Cdd:COG4886   106 NEELSNLTNLESLDLSGNQLTDLP----------------------EELANLTNLKELDLSNN---------QLTDLPEP 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  200 FLNMRNLKLLSLKDNNISAVPTVLP--SSLTELYLYNNIITKIQEdDFNNLSQLQVLDLSGNcprcynvpfpctpcenns 277
Cdd:COG4886   155 LGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGN------------------ 215

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 529016127  278 PLQIDPNAFDALTELQVLRLHSNSLQHVPqrWFKNINKLKELDLSQNFL 326
Cdd:COG4886   216 QLTDLPEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL 262
TIR smart00255
Toll - interleukin 1 - resistance;
891-1036 1.51e-13

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 68.89  E-value: 1.51e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127    891 CYDAFIVYdtkdpAVTEWVLDELVAKLEDpREKCFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKI 970
Cdd:smart00255    1 EYDVFISY-----SGKEDVRNEFLSHLLE-KLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLD 74

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127    971 AFYLSHQRLMDEKVDVIILIFLEK----PLQKSKFLQLRKRlcgSSVLEWPTNPQAHpyFWQCLKNALAT 1036
Cdd:smart00255   75 ELVAALENALEEGGLRVIPIFYEVipsdVRKQPGKFRKVFK---KNYLKWPEDEKEQ--FWKKALYAVPS 139
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 246-785 9.73e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 66.02  E-value: 9.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  246 NNLSQLQVLDLSGNcprcynvpfpctpcenNSPLQIDPNAFdALTELQVLRLHSNSLQ-HVPQRWFKNINKLKELDLSQN 324
Cdd:PLN00113   66 NNSSRVVSIDLSGK----------------NISGKISSAIF-RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNN 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  325 FLAKEIGDAkflhLLHNLVNLDLSFNydlQVYHAVINLSDAFSSLKklkVLRIKGYVF--KELNSLNlfplhNLPNLEVL 402
Cdd:PLN00113  129 NFTGSIPRG----SIPNLETLDLSNN---MLSGEIPNDIGSFSSLK---VLDLGGNVLvgKIPNSLT-----NLTSLEFL 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  403 DLGTNFIKIANLSIFNQFKTLKFIDLSVNKISpsGDSPE--GGFCSNRR-----TSVEGHGPQV---LETLHY-FRYDEy 471
Cdd:PLN00113  194 TLASNQLVGQIPRELGQMKSLKWIYLGYNNLS--GEIPYeiGGLTSLNHldlvyNNLTGPIPSSlgnLKNLQYlFLYQN- 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  472 arscRSKSKEPPSFLPLNEDCymygqTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNSISQTLNGSeFQPLVELKYLDFS 551
Cdd:PLN00113  271 ----KLSGPIPPSIFSLQKLI-----SLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVA-LTSLPRLQVLQLW 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  552 NNRLDLLYSTAFEELHNLEVLDISSNShyfQSEGITHMLNFTKNLKvlrKLMMNYNDI------ATSTSRTMESESLQIL 625
Cdd:PLN00113  341 SNKFSGEIPKNLGKHNNLTVLDLSTNN---LTGEIPEGLCSSGNLF---KLILFSNSLegeipkSLGACRSLRRVRLQDN 414

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  626 EFRGNhldiLWRDGDNRYLKFFknllnleeLDISENSLSflplGVFDSMP---PNLKTLSLAKNglkSFSWERLQSL--K 700
Cdd:PLN00113  415 SFSGE----LPSEFTKLPLVYF--------LDISNNNLQ----GRINSRKwdmPSLQMLSLARN---KFFGGLPDSFgsK 475

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  701 NLETLDLSFNQLK-TVPERLSNCSRsLKKLILKNNQIRCLTKYFLQGAFQLRHLDLSSNKIQVIQKTSFPE-NVLNNLNi 778
Cdd:PLN00113  476 RLENLDLSRNQFSgAVPRKLGSLSE-LMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEmPVLSQLD- 553


                  ....*..
gi 529016127  779 lfLHHNR 785
Cdd:PLN00113  554 --LSQNQ 558
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
108-307 2.39e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.64  E-value: 2.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  108 KDNVCTKRLQIKPNSFSKLTYLKSLYLDGNQLLEIPQDLPPSLQLLSLEANNIFLImKENLTElaNLEILYLGQNCYYRN 187
Cdd:PRK15370  180 KTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSI-PATLPD--TIQEMELSINRITEL 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  188 PCNVSFTIEK-DAFLNM---------RNLKLLSLKDNNISAVPTVLPSSLTELYLYNNIIT----------KIQEDDFNN 247
Cdd:PRK15370  257 PERLPSALQSlDLFHNKisclpenlpEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTalpetlppglKTLEAGENA 336

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 529016127  248 LS--------QLQVLDLSGNCPRCYNVPFPCTPCEnnspLQIDPNAFDALTE-----LQVLRLHSNSLQHVPQ 307
Cdd:PRK15370  337 LTslpaslppELQVLDVSKNQITVLPETLPPTITT----LDVSRNALTNLPEnlpaaLQIMQASRNNLVRLPE 405
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 198-326 9.47e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.72  E-value: 9.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  198 DAFLNMRNLKLLSLKDNNISAVPTVLP-SSLTELYLYNNIITKIqeDDFNNLSQLQVLDLSGNCPRC----YNvpfpctp 272
Cdd:cd21340    18 DNLSLCKNLKVLYLYDNKITKIENLEFlTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVveglEN------- 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 529016127  273 CEN-------------NSPLQIDPNAFDALTE-LQVLRLHSNSLQHVpqRWFKNINKLKELDLSQNFL 326
Cdd:cd21340    89 LTNleelhienqrlppGEKLTFDPRSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI 154
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 892-1017 1.71e-08

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 55.06  E-value: 1.71e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127   892 YDAFIVYDTKDpaVTEWVLDELVAKLedpREKCFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKT----EN 967
Cdd:pfam01582    1 YDVFLSFRGSD--TREWFVSHLLKEL---KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgwclDE 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 529016127   968 FKIAfylshQRLMDEKVDVIILIFLEK-----PLQKSKFLQLRKRLCG----SSVLEWP 1017
Cdd:pfam01582   76 LVKI-----LECALDLGQKVIPIFYEVdpsdvRKQTGSFGKAFKKHKKvlteEKVLKWR 129
LRR_8 pfam13855
Leucine rich repeat;
497-555 4.19e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 4.19e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 529016127   497 QTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNSISqTLNGSEFQPLVELKYLDFSNNRL 555
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT-TLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 640-784 1.16e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 1.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  640 DNR--YLKFFKNLLNLEELDISENSLSFLPlgVFDSMPpNLKTLSLAKNGLKSFswERLQSLKNLETLDLSFNQLKT--- 714
Cdd:cd21340    33 DNKitKIENLEFLTNLTHLYLQNNQIEKIE--NLENLV-NLKKLYLGGNRISVV--EGLENLTNLEELHIENQRLPPgek 107

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 529016127  715 ---VPERLSNCSRSLKKLILKNNQIRCLTkyFLQGAFQLRHLDLSSNKIQVIQKTSFPENVLNNLNILFLHHN 784
Cdd:cd21340   108 ltfDPRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 364-577 3.11e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.40  E-value: 3.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  364 DAFSSLKKLKVLrikgYVFKelNSLNLFP-LHNLPNLEVLDLGTNFI-KIANLsifNQFKTLKFIDLSVNKISpsgdspe 441
Cdd:cd21340    18 DNLSLCKNLKVL----YLYD--NKITKIEnLEFLTNLTHLYLQNNQIeKIENL---ENLVNLKKLYLGGNRIS------- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  442 ggfcsnrrtSVEG-HGPQVLETLHYfrydEYARscrskskeppsfLPLnedcymyGQTLDLSRNNIFFIKPSdfqhlsfL 520
Cdd:cd21340    82 ---------VVEGlENLTNLEELHI----ENQR------------LPP-------GEKLTFDPRSLAALSNS-------L 122

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 529016127  521 KCLNLSGNSISqtlNGSEFQPLVELKYLDFSNNRLDLL--YSTAFEELHNLEVLDISSN 577
Cdd:cd21340   123 RVLNISGNNID---SLEPLAPLRNLEQLDASNNQISDLeeLLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
225-302 4.86e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 4.86e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 529016127   225 SSLTELYLYNNIITKIQEDDFNNLSQLQVLDLSGNCPRCynvpfpctpcennsplqIDPNAFDALTELQVLRLHSNSL 302
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-----------------LSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 754-838 1.23e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.70  E-value: 1.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127   754 DLSSNKIQVIQKTSFpeNVLNNLNILFLHHNRFLCNCDAVWFVWWVNHTEVTI--PYLAtdvTCMGPGAHKGQSVVSLDL 831
Cdd:TIGR00864    1 DISNNKISTIEEGIC--ANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqPEAA---LCAGPGALAGQPLLGIPL 75


                   ....*..
gi 529016127   832 YTCELDL 838
Cdd:TIGR00864   76 LDSGCDE 82
LRR_12 pfam18837
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 399-428 1.50e-05

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


Pssm-ID: 408607  Cd Length: 30  Bit Score: 42.72  E-value: 1.50e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 529016127   399 LEVLDLGTNFIKIANLSIFNQFKTLKFIDL 428
Cdd:pfam18837    1 LQTLHLQMNFINQAQLSIFGAFPGLRFVDL 30
LRR_8 pfam13855
Leucine rich repeat;
66-139 6.31e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 6.31e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 529016127    66 NATNLTLTINHIAGISPASFHRLDHLVEIDFRCNCVPVrlgpkdnvctkrlqIKPNSFSKLTYLKSLYLDGNQL 139
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--------------LSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
498-786 2.90e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.53  E-value: 2.90e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  498 TLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNSISQTLNGSEFQPLVELKYLDFSNNRldllystAFEELHNLEVLDISSN 577
Cdd:COG4886    51 LLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGN 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  578 ShyfqsegITHMLNFTKNLKVLRKLMMNYNDIATstsrtmeseslqilefrgnhldilwrdgdnrYLKFFKNLLNLEELD 657
Cdd:COG4886   124 Q-------LTDLPEELANLTNLKELDLSNNQLTD-------------------------------LPEPLGNLTNLKSLD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  658 ISENSLSFLPLGVFDSmpPNLKTLSLAKNGLKSFSWErLQSLKNLETLDLSFNQLKTVPERLSNCSrSLKKLILKNNQIR 737
Cdd:COG4886   166 LSNNQLTDLPEELGNL--TNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEPLANLT-NLETLDLSNNQLT 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 529016127  738 CLTKyfLQGAFQLRHLDLSSNKIqviqkTSFPENV-LNNLNILFLHHNRF 786
Cdd:COG4886   242 DLPE--LGNLTNLEELDLSNNQL-----TDLPPLAnLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
497-840 3.56e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 3.56e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  497 QTLDLSRNNiffikpsDFQHLSFLKCLNLSGNSISQTlnGSEFQPLVELKYLDFSNNRLDLLySTAFEELHNLEVLDISS 576
Cdd:COG4886    99 TELDLSGNE-------ELSNLTNLESLDLSGNQLTDL--PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSN 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  577 NshyfqseGITHMLNFTKNLKVLRKLMMNYNDIATSTSRTMESESLQILEFRGNHLDILwrdgdnryLKFFKNLLNLEEL 656
Cdd:COG4886   169 N-------QLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDL--------PEPLANLTNLETL 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  657 DISENSLSFLPlgVFDSMPpNLKTLSLAKNGLKSFSweRLQSLKNLETLDLSFNQLKTVP-ERLSNCSRSLKKLILKNNQ 735
Cdd:COG4886   234 DLSNNQLTDLP--ELGNLT-NLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLL 308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  736 IRCLTKYFLQGAFQLRHLDLSSNKIQVIQKTSFPENVLNNLNILFLHHNRFLCNCDAVWFVWWVNHTEVTIPYLATDVTC 815
Cdd:COG4886   309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLT 388

                         330       340
                  ....*....|....*....|....*
gi 529016127  816 MGPGAHKGQSVVSLDLYTCELDLTN 840
Cdd:COG4886   389 LLLLLLTTTAGVLLLTLALLDAVNT 413
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
120-326 1.55e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 1.55e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  120 PNSFSKLTYLKSLYLDGNQLLEIPqdlppslqllsleanniflimkENLTELANLEILYLGQNcyyrnpcnvSFTIEKDA 199
Cdd:COG4886   106 NEELSNLTNLESLDLSGNQLTDLP----------------------EELANLTNLKELDLSNN---------QLTDLPEP 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  200 FLNMRNLKLLSLKDNNISAVPTVLP--SSLTELYLYNNIITKIQEdDFNNLSQLQVLDLSGNcprcynvpfpctpcenns 277
Cdd:COG4886   155 LGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGN------------------ 215

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 529016127  278 PLQIDPNAFDALTELQVLRLHSNSLQHVPqrWFKNINKLKELDLSQNFL 326
Cdd:COG4886   216 QLTDLPEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
116-434 3.76e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 3.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  116 LQIKPNSFSKLTYLKSLYLDGNQLLEIPQDLPPSLQLLSLEANNIFLIMKENLTELANLEILYLGQNCYYRNPCNVSFTI 195
Cdd:COG4886     8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  196 EKDAFLNMRNLKLLSLKDNNISAVPTvlpsSLTELYLYNNIITKIqEDDFNNLSQLQVLDLSGNcprcynvpfpctpcen 275
Cdd:COG4886    88 GLTDLGDLTNLTELDLSGNEELSNLT----NLESLDLSGNQLTDL-PEELANLTNLKELDLSNN---------------- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  276 nsPLQIDPNAFDALTELQVLRLHSNSLQHVPqRWFKNINKLKELDLSQN---FLAKEIGDAKflhllhNLVNLDLSFNyd 352
Cdd:COG4886   147 --QLTDLPEPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNqitDLPEPLGNLT------NLEELDLSGN-- 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  353 lqvyhAVINLSDAFSSLKKLKVLRIKGyvfkelNSLNLFP-LHNLPNLEVLDLGTNfiKIANLSIFNQFKTLKFIDLSVN 431
Cdd:COG4886   216 -----QLTDLPEPLANLTNLETLDLSN------NQLTDLPeLGNLTNLEELDLSNN--QLTDLPPLANLTNLKTLDLSNN 282


                  ...
gi 529016127  432 KIS 434
Cdd:COG4886   283 QLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
120-432 1.47e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 1.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  120 PNSFSKLTYLKSLYLDGNQLLEIPqdlppslqllsleanniflimkENLTELANLEILYLGQNcyyrnpcnvSFTIEKDA 199
Cdd:COG4886   129 PEELANLTNLKELDLSNNQLTDLP----------------------EPLGNLTNLKSLDLSNN---------QLTDLPEE 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  200 FLNMRNLKLLSLKDNNISAVPTVL--PSSLTELYLYNNIITKIqEDDFNNLSQLQVLDLSGNcprcynvpfpctpcenns 277
Cdd:COG4886   178 LGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNN------------------ 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  278 plQI-DPNAFDALTELQVLRLHSNSLQHVPQrwFKNINKLKELDLSQNFLAK-EIGDAKFLHLLHNLVNLDLSFNYDLQV 355
Cdd:COG4886   239 --QLtDLPELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDlKLKELELLLGLNSLLLLLLLLNLLELL 314

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 529016127  356 YHAVINLSDAFSSLKKLKVLRIKGYVFKELNSLNLFPLHNLPNLEVLDLGTNFIKIANLSIFNQFKTLKFIDLSVNK 432
Cdd:COG4886   315 ILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
605-786 1.30e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 1.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  605 NYNDIATSTSRTMESESLQILEFRGNHLDILWRDGDNRYLKFFKNLLNLEELDISENSlsflPLGVFdsmpPNLKTLSLA 684
Cdd:COG4886    50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE----ELSNL----TNLESLDLS 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  685 KNGLKSFSWErLQSLKNLETLDLSFNQLKTVPERLSNCSrSLKKLILKNNQIRCLTKyFLQGAFQLRHLDLSSNKIqviq 764
Cdd:COG4886   122 GNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEPLGNLT-NLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQI---- 194

                         170       180
                  ....*....|....*....|....
gi 529016127  765 kTSFPENV--LNNLNILFLHHNRF 786
Cdd:COG4886   195 -TDLPEPLgnLTNLEELDLSGNQL 217
TIR smart00255
Toll - interleukin 1 - resistance;
891-1036 1.51e-13

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 68.89  E-value: 1.51e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127    891 CYDAFIVYdtkdpAVTEWVLDELVAKLEDpREKCFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKI 970
Cdd:smart00255    1 EYDVFISY-----SGKEDVRNEFLSHLLE-KLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLD 74

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127    971 AFYLSHQRLMDEKVDVIILIFLEK----PLQKSKFLQLRKRlcgSSVLEWPTNPQAHpyFWQCLKNALAT 1036
Cdd:smart00255   75 ELVAALENALEEGGLRVIPIFYEVipsdVRKQPGKFRKVFK---KNYLKWPEDEKEQ--FWKKALYAVPS 139
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 246-785 9.73e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 66.02  E-value: 9.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  246 NNLSQLQVLDLSGNcprcynvpfpctpcenNSPLQIDPNAFdALTELQVLRLHSNSLQ-HVPQRWFKNINKLKELDLSQN 324
Cdd:PLN00113   66 NNSSRVVSIDLSGK----------------NISGKISSAIF-RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNN 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  325 FLAKEIGDAkflhLLHNLVNLDLSFNydlQVYHAVINLSDAFSSLKklkVLRIKGYVF--KELNSLNlfplhNLPNLEVL 402
Cdd:PLN00113  129 NFTGSIPRG----SIPNLETLDLSNN---MLSGEIPNDIGSFSSLK---VLDLGGNVLvgKIPNSLT-----NLTSLEFL 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  403 DLGTNFIKIANLSIFNQFKTLKFIDLSVNKISpsGDSPE--GGFCSNRR-----TSVEGHGPQV---LETLHY-FRYDEy 471
Cdd:PLN00113  194 TLASNQLVGQIPRELGQMKSLKWIYLGYNNLS--GEIPYeiGGLTSLNHldlvyNNLTGPIPSSlgnLKNLQYlFLYQN- 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  472 arscRSKSKEPPSFLPLNEDCymygqTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNSISQTLNGSeFQPLVELKYLDFS 551
Cdd:PLN00113  271 ----KLSGPIPPSIFSLQKLI-----SLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVA-LTSLPRLQVLQLW 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  552 NNRLDLLYSTAFEELHNLEVLDISSNShyfQSEGITHMLNFTKNLKvlrKLMMNYNDI------ATSTSRTMESESLQIL 625
Cdd:PLN00113  341 SNKFSGEIPKNLGKHNNLTVLDLSTNN---LTGEIPEGLCSSGNLF---KLILFSNSLegeipkSLGACRSLRRVRLQDN 414

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  626 EFRGNhldiLWRDGDNRYLKFFknllnleeLDISENSLSflplGVFDSMP---PNLKTLSLAKNglkSFSWERLQSL--K 700
Cdd:PLN00113  415 SFSGE----LPSEFTKLPLVYF--------LDISNNNLQ----GRINSRKwdmPSLQMLSLARN---KFFGGLPDSFgsK 475

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  701 NLETLDLSFNQLK-TVPERLSNCSRsLKKLILKNNQIRCLTKYFLQGAFQLRHLDLSSNKIQVIQKTSFPE-NVLNNLNi 778
Cdd:PLN00113  476 RLENLDLSRNQFSgAVPRKLGSLSE-LMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEmPVLSQLD- 553


                  ....*..
gi 529016127  779 lfLHHNR 785
Cdd:PLN00113  554 --LSQNQ 558
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 190-712 2.28e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.87  E-value: 2.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  190 NVSFTIEKDAFLNMRNLKLLSLKDNNIS-AVPTVLPSSLTELYLYNNIITKIQEDDFNNLSQLQVLDLSGNCprcynvpf 268
Cdd:PLN00113  104 QLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNV-------- 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  269 pctpcennsPLQIDPNAFDALTELQVLRLHSNSLQHVPQRWFKNINKLKELDLSQNFLAKEIgdAKFLHLLHNLVNLDLS 348
Cdd:PLN00113  176 ---------LVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEI--PYEIGGLTSLNHLDLV 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  349 FNydlqvyhaviNLSDAF-SSLKKLKVLRikgYVFKELNSLN-LFP--LHNLPNLEVLDLGTNFI--KIANLSIfnQFKT 422
Cdd:PLN00113  245 YN----------NLTGPIpSSLGNLKNLQ---YLFLYQNKLSgPIPpsIFSLQKLISLDLSDNSLsgEIPELVI--QLQN 309

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  423 LKFIDLSVNKIspSGDSPeGGFCSNRRTsveghgpQVLEtLHYFRYdeyarscrskSKEPPSFLPLNEDCymygQTLDLS 502
Cdd:PLN00113  310 LEILHLFSNNF--TGKIP-VALTSLPRL-------QVLQ-LWSNKF----------SGEIPKNLGKHNNL----TVLDLS 364

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  503 RNNIFFIKPSDFQHLSFLKCLNLSGNSISQTLNGSeFQPLVELKYLDFSNNRLDLLYSTAFEELHNLEVLDISSNshyfq 582
Cdd:PLN00113  365 TNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKS-LGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNN----- 438

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  583 segithmlNFTKNLkvlrklmmnyndiatsTSRTMESESLQILEFRGNhldilwrdgdnrylKFFKNL------LNLEEL 656
Cdd:PLN00113  439 --------NLQGRI----------------NSRKWDMPSLQMLSLARN--------------KFFGGLpdsfgsKRLENL 480

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 529016127  657 DISENSLS-FLPLGvFDSMpPNLKTLSLAKNGLKSFSWERLQSLKNLETLDLSFNQL 712
Cdd:PLN00113  481 DLSRNQFSgAVPRK-LGSL-SELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
156-434 2.36e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.72  E-value: 2.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  156 EANNIFLIMKENLTELANLEILYLGQNCYYRNPCNVSFTIEKDAFLNMRNLKLLSLKDNNISAVPTVLPSSLTELYLYNN 235
Cdd:COG4886     3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  236 IITKIQEDDFNNLSQLQVLDLSGNCPrcynvPFPCTPCE----NNSPLQIDPNAFDALTELQVLRLHSNSLQHVPqRWFK 311
Cdd:COG4886    83 SLLLLGLTDLGDLTNLTELDLSGNEE-----LSNLTNLEsldlSGNQLTDLPEELANLTNLKELDLSNNQLTDLP-EPLG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  312 NINKLKELDLSQNFLA---KEIGDAKflhllhNLVNLDLSFNydlqvyhAVINLSDAFSSLKKLKVLRIKGyvfKELNSL 388
Cdd:COG4886   157 NLTNLKSLDLSNNQLTdlpEELGNLT------NLKELDLSNN-------QITDLPEPLGNLTNLEELDLSG---NQLTDL 220

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 529016127  389 NLfPLHNLPNLEVLDLGTNfiKIANLSIFNQFKTLKFIDLSVNKIS 434
Cdd:COG4886   221 PE-PLANLTNLETLDLSNN--QLTDLPELGNLTNLEELDLSNNQLT 263
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
108-307 2.39e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.64  E-value: 2.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  108 KDNVCTKRLQIKPNSFSKLTYLKSLYLDGNQLLEIPQDLPPSLQLLSLEANNIFLImKENLTElaNLEILYLGQNCYYRN 187
Cdd:PRK15370  180 KTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSI-PATLPD--TIQEMELSINRITEL 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  188 PCNVSFTIEK-DAFLNM---------RNLKLLSLKDNNISAVPTVLPSSLTELYLYNNIIT----------KIQEDDFNN 247
Cdd:PRK15370  257 PERLPSALQSlDLFHNKisclpenlpEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTalpetlppglKTLEAGENA 336

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 529016127  248 LS--------QLQVLDLSGNCPRCYNVPFPCTPCEnnspLQIDPNAFDALTE-----LQVLRLHSNSLQHVPQ 307
Cdd:PRK15370  337 LTslpaslppELQVLDVSKNQITVLPETLPPTITT----LDVSRNALTNLPEnlpaaLQIMQASRNNLVRLPE 405
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 198-326 9.47e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.72  E-value: 9.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  198 DAFLNMRNLKLLSLKDNNISAVPTVLP-SSLTELYLYNNIITKIqeDDFNNLSQLQVLDLSGNCPRC----YNvpfpctp 272
Cdd:cd21340    18 DNLSLCKNLKVLYLYDNKITKIENLEFlTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVveglEN------- 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 529016127  273 CEN-------------NSPLQIDPNAFDALTE-LQVLRLHSNSLQHVpqRWFKNINKLKELDLSQNFL 326
Cdd:cd21340    89 LTNleelhienqrlppGEKLTFDPRSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI 154
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 892-1017 1.71e-08

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 55.06  E-value: 1.71e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127   892 YDAFIVYDTKDpaVTEWVLDELVAKLedpREKCFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKT----EN 967
Cdd:pfam01582    1 YDVFLSFRGSD--TREWFVSHLLKEL---KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgwclDE 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 529016127   968 FKIAfylshQRLMDEKVDVIILIFLEK-----PLQKSKFLQLRKRLCG----SSVLEWP 1017
Cdd:pfam01582   76 LVKI-----LECALDLGQKVIPIFYEVdpsdvRKQTGSFGKAFKKHKKvlteEKVLKWR 129
LRR_8 pfam13855
Leucine rich repeat;
497-555 4.19e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 4.19e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 529016127   497 QTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNSISqTLNGSEFQPLVELKYLDFSNNRL 555
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT-TLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 640-784 1.16e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 1.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  640 DNR--YLKFFKNLLNLEELDISENSLSFLPlgVFDSMPpNLKTLSLAKNGLKSFswERLQSLKNLETLDLSFNQLKT--- 714
Cdd:cd21340    33 DNKitKIENLEFLTNLTHLYLQNNQIEKIE--NLENLV-NLKKLYLGGNRISVV--EGLENLTNLEELHIENQRLPPgek 107

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 529016127  715 ---VPERLSNCSRSLKKLILKNNQIRCLTkyFLQGAFQLRHLDLSSNKIQVIQKTSFPENVLNNLNILFLHHN 784
Cdd:cd21340   108 ltfDPRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
48-259 1.53e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 1.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127   48 IVDCTDKHLTEIPGGIpANATNLT---LTINHIAGIsPASFHRLDHLVEIDFRCNcvpvrlgpkdnvctkRLQIKPNSFS 124
Cdd:COG4886   140 ELDLSNNQLTDLPEPL-GNLTNLKsldLSNNQLTDL-PEELGNLTNLKELDLSNN---------------QITDLPEPLG 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  125 KLTYLKSLYLDGNQLLEIPqdlppslqllsleanniflimkENLTELANLEILYLGQNcyyrnpcNVSftiEKDAFLNMR 204
Cdd:COG4886   203 NLTNLEELDLSGNQLTDLP----------------------EPLANLTNLETLDLSNN-------QLT---DLPELGNLT 250

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 529016127  205 NLKLLSLKDNNISAVPTVLP-SSLTELYLYNNIITKIQEDDFNNLSQLQVLDLSGN 259
Cdd:COG4886   251 NLEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
LRR_8 pfam13855
Leucine rich repeat;
676-736 2.01e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 2.01e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 529016127   676 PNLKTLSLAKNGLKSFSWERLQSLKNLETLDLSFNQLKTVPERLSNCSRSLKKLILKNNQI 736
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 123-259 7.75e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.33  E-value: 7.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  123 FSKLTYLKSLYLDGNQLLEIpqdlppslqllsleanniflimkENLTELANLEILYLGQNC------------------- 183
Cdd:cd21340    42 LEFLTNLTHLYLQNNQIEKI-----------------------ENLENLVNLKKLYLGGNRisvveglenltnleelhie 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  184 YYRNPCNVSFTIEKDAFLNMRN-LKLLSLKDNNISAV-PTVLPSSLTELYLYNNIITKIQE--DDFNNLSQLQVLDLSGN 259
Cdd:cd21340    99 NQRLPPGEKLTFDPRSLAALSNsLRVLNISGNNIDSLePLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 620-760 9.89e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.97  E-value: 9.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  620 ESLQILEFRGNHLDilwRDGDN--RYLKFFKNLLNLEELDISENSLSFLPLGVFDSM----------------------- 674
Cdd:cd00116    51 PSLKELCLSLNETG---RIPRGlqSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLlrssslqelklnnnglgdrglrl 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  675 --------PPNLKTLSLAKNGLKSFSWER----LQSLKNLETLDLSFNQL------KTVPERLSNCsrSLKKLILKNNQI 736
Cdd:cd00116   128 lakglkdlPPALEKLVLGRNRLEGASCEAlakaLRANRDLKELNLANNGIgdagirALAEGLKANC--NLEVLDLNNNGL 205

                         170       180
                  ....*....|....*....|....*...
gi 529016127  737 RCLTKYFLQGAF----QLRHLDLSSNKI 760
Cdd:cd00116   206 TDEGASALAETLaslkSLEVLNLGDNNL 233
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
656-784 2.74e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 2.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  656 LDISENSLSFLPlgvfDSMPPNLKTLSLAKNGLKSFSwERLQSlkNLETLDLSFNQLKTVPERLSNcsrSLKKLILKNNQ 735
Cdd:PRK15370  204 LILDNNELKSLP----ENLQGNIKTLYANSNQLTSIP-ATLPD--TIQEMELSINRITELPERLPS---ALQSLDLFHNK 273

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 529016127  736 IRCLTKYFLQGafqLRHLDLSSNKIqviqkTSFPENVLNNLNILFLHHN 784
Cdd:PRK15370  274 ISCLPENLPEE---LRYLSVYDNSI-----RTLPAHLPSGITHLNVQSN 314
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 364-577 3.11e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.40  E-value: 3.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  364 DAFSSLKKLKVLrikgYVFKelNSLNLFP-LHNLPNLEVLDLGTNFI-KIANLsifNQFKTLKFIDLSVNKISpsgdspe 441
Cdd:cd21340    18 DNLSLCKNLKVL----YLYD--NKITKIEnLEFLTNLTHLYLQNNQIeKIENL---ENLVNLKKLYLGGNRIS------- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  442 ggfcsnrrtSVEG-HGPQVLETLHYfrydEYARscrskskeppsfLPLnedcymyGQTLDLSRNNIFFIKPSdfqhlsfL 520
Cdd:cd21340    82 ---------VVEGlENLTNLEELHI----ENQR------------LPP-------GEKLTFDPRSLAALSNS-------L 122

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 529016127  521 KCLNLSGNSISqtlNGSEFQPLVELKYLDFSNNRLDLL--YSTAFEELHNLEVLDISSN 577
Cdd:cd21340   123 RVLNISGNNID---SLEPLAPLRNLEQLDASNNQISDLeeLLDLLSSWPSLRELDLTGN 178
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
605-786 4.30e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.32  E-value: 4.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  605 NYNDIATSTSRTMESESLQILEFRGNHLDILWRDGDNRYLKFFKNLLNLEELDISENSLSFLPLGVFDSMPPNLKTLSLA 684
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  685 KNGLKSFSWERLQSLKNLETLDLSF-----------------NQLKTVPERLSNCSrSLKKLILKNNQIRCLTKyFLQGA 747
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGneelsnltnlesldlsgNQLTDLPEELANLT-NLKELDLSNNQLTDLPE-PLGNL 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 529016127  748 FQLRHLDLSSNKIqviqkTSFPENV--LNNLNILFLHHNRF 786
Cdd:COG4886   159 TNLKSLDLSNNQL-----TDLPEELgnLTNLKELDLSNNQI 194
LRR_8 pfam13855
Leucine rich repeat;
225-302 4.86e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 4.86e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 529016127   225 SSLTELYLYNNIITKIQEDDFNNLSQLQVLDLSGNCPRCynvpfpctpcennsplqIDPNAFDALTELQVLRLHSNSL 302
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-----------------LSPGAFSGLPSLRYLDLSGNRL 61
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 895-993 5.24e-06

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 46.54  E-value: 5.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127   895 FIVYDTKDPAVTEWVLDELvakledpREKCFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKIAFYL 974
Cdd:pfam13676    2 FISYAGEDRAWAEWLADAL-------EAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEA 74

                           90
                   ....*....|....*....
gi 529016127   975 SHQRLMDEKvdVIILIFLE 993
Cdd:pfam13676   75 ALADPEGRK--RLIPVRLE 91
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
569-719 1.15e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 49.31  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  569 LEVLDISSNSHYFQSEGIT------HMLNFTKNLKV-LRKLMMNYNDIAT------STSRTME-------------SESL 622
Cdd:PRK15370  185 LKILGLTTIPACIPEQITTlildnnELKSLPENLQGnIKTLYANSNQLTSipatlpDTIQEMElsinritelperlPSAL 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  623 QILEFRGNHLDILwrdGDN-----RYLKFFKNLL---------NLEELDISENSLSFLPlgvfDSMPPNLKTLSLAKNGL 688
Cdd:PRK15370  265 QSLDLFHNKISCL---PENlpeelRYLSVYDNSIrtlpahlpsGITHLNVQSNSLTALP----ETLPPGLKTLEAGENAL 337

                         170       180       190
                  ....*....|....*....|....*....|.
gi 529016127  689 KSFSWERLQSLKNletLDLSFNQLKTVPERL 719
Cdd:PRK15370  338 TSLPASLPPELQV---LDVSKNQITVLPETL 365
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 754-838 1.23e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.70  E-value: 1.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127   754 DLSSNKIQVIQKTSFpeNVLNNLNILFLHHNRFLCNCDAVWFVWWVNHTEVTI--PYLAtdvTCMGPGAHKGQSVVSLDL 831
Cdd:TIGR00864    1 DISNNKISTIEEGIC--ANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqPEAA---LCAGPGALAGQPLLGIPL 75


                   ....*..
gi 529016127   832 YTCELDL 838
Cdd:TIGR00864   76 LDSGCDE 82
LRR_8 pfam13855
Leucine rich repeat;
520-577 1.42e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 1.42e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 529016127   520 LKCLNLSGNSIsQTLNGSEFQPLVELKYLDFSNNRLDLLYSTAFEELHNLEVLDISSN 577
Cdd:pfam13855    3 LRSLDLSNNRL-TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_12 pfam18837
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 399-428 1.50e-05

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


Pssm-ID: 408607  Cd Length: 30  Bit Score: 42.72  E-value: 1.50e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 529016127   399 LEVLDLGTNFIKIANLSIFNQFKTLKFIDL 428
Cdd:pfam18837    1 LQTLHLQMNFINQAQLSIFGAFPGLRFVDL 30
LRR_8 pfam13855
Leucine rich repeat;
204-259 1.61e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.61e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 529016127   204 RNLKLLSLKDNNISAVPTVL---PSSLTELYLYNNIITKIQEDDFNNLSQLQVLDLSGN 259
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 613-786 1.76e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.08  E-value: 1.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  613 TSRTMESESLQILEFRGNHL------DILWRDGDNRYLKFFKN----------LLNLEELDISENSLS---FLPLGVFDs 673
Cdd:PLN00113   86 SSAIFRLPYIQTINLSNNQLsgpipdDIFTTSSSLRYLNLSNNnftgsiprgsIPNLETLDLSNNMLSgeiPNDIGSFS- 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  674 mppNLKTLSLAKNGLKSFSWERLQSLKNLETLDLSFNQL-KTVPERLSNCsRSLKKLILKNNQIRCLTKYFLQGAFQLRH 752
Cdd:PLN00113  165 ---SLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvGQIPRELGQM-KSLKWIYLGYNNLSGEIPYEIGGLTSLNH 240

                         170       180       190
                  ....*....|....*....|....*....|....
gi 529016127  753 LDLSSNKIQVIQKTSFPEnvLNNLNILFLHHNRF 786
Cdd:PLN00113  241 LDLVYNNLTGPIPSSLGN--LKNLQYLFLYQNKL 272
LRR_8 pfam13855
Leucine rich repeat;
275-324 2.14e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 2.14e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 529016127   275 NNSPLQIDPNAFDALTELQVLRLHSNSLQHVPQRWFKNINKLKELDLSQN 324
Cdd:pfam13855   10 NNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 499-686 2.24e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.70  E-value: 2.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  499 LDLSRNNIFFIkpSDFQHLSFLKCLNLSGNSISqTLNGSEFQP-LVELkYLdfSNNRLDLLysTAFEELHNLEVLDISSN 577
Cdd:cd21340     7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKIT-KIENLEFLTnLTHL-YL--QNNQIEKI--ENLENLVNLKKLYLGGN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  578 ShyfqsegITHMLNFTkNLKVLRKLMMNYNDIATSTS-----RTME--SESLQILEFRGNHLDilwrdgdnrYLKFFKNL 650
Cdd:cd21340    79 R-------ISVVEGLE-NLTNLEELHIENQRLPPGEKltfdpRSLAalSNSLRVLNISGNNID---------SLEPLAPL 141

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 529016127  651 LNLEELDISENSLSFLP--LGVFDSMpPNLKTLSLAKN 686
Cdd:cd21340   142 RNLEQLDASNNQISDLEelLDLLSSW-PSLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 209-434 2.30e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.70  E-value: 2.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  209 LSLKDNNISAVPTV-LPSSLTELYLYNNIITKIqeDDFNNLSQLQVLDLSGNCPRCynvpfpctpcennsplqIDPnaFD 287
Cdd:cd21340     7 LYLNDKNITKIDNLsLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEK-----------------IEN--LE 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  288 ALTELQVLRLHSNSLQHVPQrwFKNINKLKELDLSQNFLAKEigdakflhllhnlvnLDLSFNYDLqvyhavinlsdAFS 367
Cdd:cd21340    66 NLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPG---------------EKLTFDPRS-----------LAA 117

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  368 SLKKLKVLRIKGyvfkelNSL-NLFPLHNLPNLEVLDLGTNFIK-IANLS-IFNQFKTLKFIDLSVNKIS 434
Cdd:cd21340   118 LSNSLRVLNISG------NNIdSLEPLAPLRNLEQLDASNNQISdLEELLdLLSSWPSLRELDLTGNPVC 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 59-441 2.51e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.31  E-value: 2.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127   59 IPGGIPANATNLTLTINHIAGISPAsfhrldhlvEIDFRCNCVPVRLGpkDNVCTKRLqikPNSFSKLTYLKSLYLDGNQ 138
Cdd:PLN00113  134 IPRGSIPNLETLDLSNNMLSGEIPN---------DIGSFSSLKVLDLG--GNVLVGKI---PNSLTNLTSLEFLTLASNQ 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  139 LL-EIPQDlppslqllsleanniflimkenLTELANLEILYLGQNcyyrnpcNVSFTIEKDaFLNMRNLKLLSLKDNNIS 217
Cdd:PLN00113  200 LVgQIPRE----------------------LGQMKSLKWIYLGYN-------NLSGEIPYE-IGGLTSLNHLDLVYNNLT 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  218 A-VPTVLP--SSLTELYLYNNIITKIQEDDFNNLSQLQVLDLSGNCpRCYNVPFPCTPCENNSPLQI--------DPNAF 286
Cdd:PLN00113  250 GpIPSSLGnlKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNS-LSGEIPELVIQLQNLEILHLfsnnftgkIPVAL 328

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  287 DALTELQVLRLHSNSLQ-HVPQRWFKNiNKLKELDLSQNFLAKEIGDAK-----------FLHLLHNLVNLDLSF----- 349
Cdd:PLN00113  329 TSLPRLQVLQLWSNKFSgEIPKNLGKH-NNLTVLDLSTNNLTGEIPEGLcssgnlfklilFSNSLEGEIPKSLGAcrslr 407

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  350 NYDLQVYHAVINLSDAFSSLKKLKVLRIKGYVFK--------ELNSLNLFPLH------NLP------NLEVLDLGTNFI 409
Cdd:PLN00113  408 RVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgrinsrkwDMPSLQMLSLArnkffgGLPdsfgskRLENLDLSRNQF 487

                         410       420       430
                  ....*....|....*....|....*....|..
gi 529016127  410 KIANLSIFNQFKTLKFIDLSVNKIspSGDSPE 441
Cdd:PLN00113  488 SGAVPRKLGSLSELMQLKLSENKL--SGEIPD 517
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
164-326 2.53e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.54  E-value: 2.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  164 MKENLTELAnLEILYLGQNCYYRNPCNVSFTIEKDAFLNM-----RNLKLLSLKDNNISAVPTVLPSSLTELYLYNNIIT 238
Cdd:PRK15370  176 LKNNKTELR-LKILGLTTIPACIPEQITTLILDNNELKSLpenlqGNIKTLYANSNQLTSIPATLPDTIQEMELSINRIT 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  239 KIQEddfNNLSQLQVLDLSGNcprcynvPFPCTPceNNSPlqidpnafdalTELQVLRLHSNSLQHVPQRWFKNINKLKE 318
Cdd:PRK15370  255 ELPE---RLPSALQSLDLFHN-------KISCLP--ENLP-----------EELRYLSVYDNSIRTLPAHLPSGITHLNV 311


                  ....*...
gi 529016127  319 LDLSQNFL 326
Cdd:PRK15370  312 QSNSLTAL 319
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
31-323 3.37e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.77  E-value: 3.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127   31 PKTLPcdvtldapNTHVIVDCTDKHLTEIPGGIPANATNLTLTINHIAGISPASFHRLDHLVEIDFRCNCVPVRLgpkdn 110
Cdd:PRK15370  236 PATLP--------DTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHL----- 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  111 vctkrlqikPNSFSKltylksLYLDGNQLLEIPQdlppslqllsleanniflimkenlTELANLEILYLGQNCYYRNPCN 190
Cdd:PRK15370  303 ---------PSGITH------LNVQSNSLTALPE------------------------TLPPGLKTLEAGENALTSLPAS 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  191 VSftiekdaflnmRNLKLLSLKDNNISAVPTVLPSSLTELYLYNNIIT----------KIQEDDFNNLSQL--QVLDLSG 258
Cdd:PRK15370  344 LP-----------PELQVLDVSKNQITVLPETLPPTITTLDVSRNALTnlpenlpaalQIMQASRNNLVRLpeSLPHFRG 412

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 529016127  259 NCPRC------YNvPFPCTPCENNSPLQID-----PNAFDALTELQVLRLhSNSLQHVPQRWfknINKLKELDLSQ 323
Cdd:PRK15370  413 EGPQPtriiveYN-PFSERTIQNMQRLMSSvgyqgPRVLFAMGDFSIVRV-TRPLHQAVQGW---LTNLEEEDVNQ 483
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 523-765 3.93e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 3.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  523 LNLSGNSISQTlngSEFQPLVELKYLDFSNNRLDLLysTAFEELHNLEVLDISSNShyfqsegITHMLNFTkNLKVLRKL 602
Cdd:cd21340     7 LYLNDKNITKI---DNLSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQ-------IEKIENLE-NLVNLKKL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  603 MMNYNDIATStsrtmesESLQilefrgnhldilwrdgdnrylkffkNLLNLEELDIS------ENSLSFLPLGVFdSMPP 676
Cdd:cd21340    74 YLGGNRISVV-------EGLE-------------------------NLTNLEELHIEnqrlppGEKLTFDPRSLA-ALSN 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  677 NLKTLSLAKNGLKSFSWerLQSLKNLETLDLSFNQLKtvperlsncsrSLKKLilknnqircltKYFLQGAFQLRHLDLS 756
Cdd:cd21340   121 SLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIS-----------DLEEL-----------LDLLSSWPSLRELDLT 176


                  ....*....
gi 529016127  757 SNKIQVIQK 765
Cdd:cd21340   177 GNPVCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
66-139 6.31e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 6.31e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 529016127    66 NATNLTLTINHIAGISPASFHRLDHLVEIDFRCNCVPVrlgpkdnvctkrlqIKPNSFSKLTYLKSLYLDGNQL 139
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--------------LSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
290-326 8.30e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 8.30e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 529016127   290 TELQVLRLHSNSLQHVPQRWFKNINKLKELDLSQNFL 326
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL 37
LRR_8 pfam13855
Leucine rich repeat;
724-786 1.15e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 1.15e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 529016127   724 RSLKKLILKNNQIRCLTKYFLQGAFQLRHLDLSSNKIQVIQKTSFPEnvLNNLNILFLHHNRF 786
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG--LPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 536-760 1.62e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.04  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  536 GSEFQPLVELKYLDFSNNRLDLLYSTAFEELH---NLEVLDISSNShyfqsEGITHMLNFTKNLK----VLRKLMMNYND 608
Cdd:cd00116    74 LQGLTKGCGLQELDLSDNALGPDGCGVLESLLrssSLQELKLNNNG-----LGDRGLRLLAKGLKdlppALEKLVLGRNR 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  609 IATSTSRTMESE-----SLQILEFRGNHLdilwRDGDNRYL-KFFKNLLNLEELDISENSLsflplgvfdsMPPNLKTLS 682
Cdd:cd00116   149 LEGASCEALAKAlranrDLKELNLANNGI----GDAGIRALaEGLKANCNLEVLDLNNNGL----------TDEGASALA 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  683 laknglksfswERLQSLKNLETLDLSFNQLKTVP-----ERLSNCSRSLKKLILKNNQIRCL-TKYFLQGAFQ---LRHL 753
Cdd:cd00116   215 -----------ETLASLKSLEVLNLGDNNLTDAGaaalaSALLSPNISLLTLSLSCNDITDDgAKDLAEVLAEkesLLEL 283


                  ....*..
gi 529016127  754 DLSSNKI 760
Cdd:cd00116   284 DLRGNKF 290
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-330 4.03e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 4.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127   61 GGIPANATNLT------LTINHIAGISPASFHRLDHLVEIDFRCNCVPVRLgPKDNVCTKRLQIK-----------PNSF 123
Cdd:PLN00113  250 GPIPSSLGNLKnlqylfLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEI-PELVIQLQNLEILhlfsnnftgkiPVAL 328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  124 SKLTYLKSLYLDGNQLL-EIPQDLPPSLQLLSLE--ANNIFLIMKENLTELANLEILYLGQNcyyrnpcnvSFTIEKDAF 200
Cdd:PLN00113  329 TSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDlsTNNLTGEIPEGLCSSGNLFKLILFSN---------SLEGEIPKS 399

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  201 LNM-RNLKLLSLKDNNISAVptvLPSSLTELYLY-------NNIITKIQEDDFNnLSQLQVLDLS-----GNCPRCynvp 267
Cdd:PLN00113  400 LGAcRSLRRVRLQDNSFSGE---LPSEFTKLPLVyfldisnNNLQGRINSRKWD-MPSLQMLSLArnkffGGLPDS---- 471

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 529016127  268 FPCTPCEN-----NSPLQIDPNAFDALTELQVLRLHSNSLQHVPQRWFKNINKLKELDLSQNFLAKEI 330
Cdd:PLN00113  472 FGSKRLENldlsrNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQI 539
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 699-785 5.60e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.47  E-value: 5.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  699 LKNLETLDLSFNQLKTVPErLSNCsRSLKKLILKNNQIRCLTKyfLQGAFQLRHLDLSSNKIQVIQktsfPENVLNNLNI 778
Cdd:cd21340     1 LKRITHLYLNDKNITKIDN-LSLC-KNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE----NLENLVNLKK 72


                  ....*..
gi 529016127  779 LFLHHNR 785
Cdd:cd21340    73 LYLGGNR 79
LRR_8 pfam13855
Leucine rich repeat;
645-688 6.74e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 6.74e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 529016127   645 KFFKNLLNLEELDISENSLSFLPLGVFDSMpPNLKTLSLAKNGL 688
Cdd:pfam13855   19 GAFKGLSNLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 676-712 2.51e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 2.51e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 529016127   676 PNLKTLSLAKNGLKSFSWerLQSLKNLETLDLSFNQL 712
Cdd:pfam12799    1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNK 35
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
44-307 2.61e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 41.69  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127   44 NTHVIVDCTDKHLTEIPGGIPANATNLTLTINHIAGIsPASFHRLDHLVEIDFRCNCVPVrLGPKdnvcTKRLQIKPNSF 123
Cdd:PRK15387  201 NGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSL-PALPPELRTLEVSGNQLTSLPV-LPPG----LLELSIFSNPL 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  124 SKLTYLKS----LYLDGNQLLEIPqdlppslqllsleanniflIMKENLTELAnleilyLGQNCYYRNPCNVSFTIEKDA 199
Cdd:PRK15387  275 THLPALPSglckLWIFGNQLTSLP-------------------VLPPGLQELS------VSDNQLASLPALPSELCKLWA 329

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529016127  200 FLNM--------RNLKLLSLKDNNISAVPTvLPSSLTELYLYNNIITKIQEDDfnnlSQLQVLDLSGNcprcYNVPFPCT 271
Cdd:PRK15387  330 YNNQltslptlpSGLQELSVSDNQLASLPT-LPSELYKLWAYNNRLTSLPALP----SGLKELIVSGN----RLTSLPVL 400

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 529016127  272 PCENNSpLQIDPNAFDAL----TELQVLRLHSNSLQHVPQ 307
Cdd:PRK15387  401 PSELKE-LMVSGNRLTSLpmlpSGLLSLSVYRNQLTRLPE 439
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 226-259 9.30e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 9.30e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 529016127   226 SLTELYLYNNIITKIqeDDFNNLSQLQVLDLSGN 259
Cdd:pfam12799    2 NLEVLDLSNNQITDI--PPLAKLPNLETLDLSGN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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