woc without children [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: wocprovided by FlyBase
Official Full Name: without childrenprovided by FlyBase
Primary source: FLYBASE:FBgn0010328
Locus tag: Dmel_CG5965
See related: AllianceGenome:FB:FBgn0010328
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5965; Dmel\CG5965; Woc; WOC
Summary: Contributes to chromatin binding activity. Involved in ecdysone biosynthetic process and regulation of transcription by RNA polymerase II. Located in chromosome and nucleus. Part of protein-containing complex. Is expressed in several structures, including amnioproctodeal invagination; embryonic cortex; epithelial furrow; ganglia; and gut section. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to several human genes including ZMYM3 (zinc finger MYM-type containing 3) and ZMYM4 (zinc finger MYM-type containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 97E11-97E11; 3-92 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (27256595..27264055, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (23082317..23089777, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results suggest that WOC and ROW play distinct functions within the HP1c complex, supporting a model in which WOC interacts with Dsk2 and recruits it to the complex, while ROW mediates binding of the complex to chromatin.
Title: The zinc-finger proteins WOC and ROW play distinct functions within the HP1c transcription complex.
Without children is required for Stat-mediated zfh1 transcription and for germline stem cell differentiation.
Title: Without children is required for Stat-mediated zfh1 transcription and for germline stem cell differentiation.
interaction between HP1c and Woc constitutes a transcriptional feedback loop that operates to balance the concentration of HP1c within the cell
Title: Drosophila HP1c is regulated by an auto-regulatory feedback loop through its binding partner Woc.
HP1c, WOC, and ROW regulate a common gene expression program that, in part, is executed in the context of the nervous system.
Title: Drosophila HP1c isoform interacts with the zinc-finger proteins WOC and Relative-of-WOC to regulate gene expression.
Woc gene mutation causes 20E-dependent alpha-tubulin detyrosination in Drosophila melanogaster.
Title: Woc gene mutation causes 20E-dependent alpha-tubulin detyrosination in Drosophila melanogaster.
Data show that mutations in the woc gene cause frequent telomeric fusions in Drosophila brain cells.
Title: The putative Drosophila transcription factor woc is required to prevent telomeric fusions.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
contributes_to chromatin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ecdysone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome interband	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: without children

Names: CG5965-PA; CG5965-PB; CG5965-PC; CG5965-PD; CG5965-PE; with out children; woc-PA; woc-PB; woc-PC; woc-PD; woc-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

27256595..27264055 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001276081.1 → NP_001263010.1 without children, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001263010.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHZ0, Q6AWL3

Conserved Domains (3) summary

smart00746
Location:683 → 720

TRASH; metallochaperone-like domain

pfam06467
Location:723 → 761

zf-FCS; MYM-type Zinc finger with FCS sequence motif

pfam12012
Location:1530 → 1689

DUF3504; Domain of unknown function (DUF3504)
NM_001104476.2 → NP_001097946.1 without children, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097946.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JRE3, Q6AWL3

Conserved Domains (3) summary

smart00746
Location:684 → 721

TRASH; metallochaperone-like domain

pfam06467
Location:724 → 762

zf-FCS; MYM-type Zinc finger with FCS sequence motif

pfam12012
Location:1531 → 1690

DUF3504; Domain of unknown function (DUF3504)
NM_001276080.1 → NP_001263009.1 without children, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001263009.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KI43, Q6AWL3

Conserved Domains (3) summary

smart00746
Location:668 → 705

TRASH; metallochaperone-like domain

pfam06467
Location:708 → 746

zf-FCS; MYM-type Zinc finger with FCS sequence motif

pfam12012
Location:1515 → 1674

DUF3504; Domain of unknown function (DUF3504)
NM_080147.3 → NP_524886.2 without children, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524886.2

Status: REVIEWED

UniProtKB/TrEMBL

Q6AWL3, Q9VB55

Related

FBpp0084548

Conserved Domains (3) summary

smart00746
Location:669 → 706

TRASH; metallochaperone-like domain

pfam06467
Location:709 → 747

zf-FCS; MYM-type Zinc finger with FCS sequence motif

pfam12012
Location:1516 → 1675

DUF3504; Domain of unknown function (DUF3504)
NM_001260397.1 → NP_001247326.1 without children, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247326.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7W6

Conserved Domains (1) summary

pfam12012
Location:540 → 699

DUF3504; Domain of unknown function (DUF3504)

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4K7W6		A0A0B4K7W6
A0A0B4KHZ0		A0A0B4KHZ0
A0A0B4KI43		A0A0B4KI43
A8JRE3		A8JRE3
Q6AWL3		Q6AWL3
Q95TK6		Q95TK6
Q9N9Z6		Q9N9Z6
Q9VB55		Q9VB55