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    grn grain [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40962, updated on 27-Aug-2024

    Summary

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    Official Symbol
    grnprovided by FlyBase
    Official Full Name
    grainprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001138
    Locus tag
    Dmel_CG9656
    See related
    AllianceGenome:FB:FBgn0001138
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9656; CG9656-PA; dGATA-2; dGatac; dGATAc; Dmel\CG9656; Gata-c; Gata2; GATAc; gra; GRAIN; Grn; l(3)84Fa
    Summary
    Enables sequence-specific DNA binding activity. Involved in animal organ morphogenesis; motor neuron axon guidance; and tissue development. Is expressed in several structures, including ectoderm; ectoderm anlage; embryonic/larval motor neurons; extended germ band embryo; and thoracic segment. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; X-linked recessive disease (multiple); hematologic cancer (multiple); hypoparathyroidism-deafness-renal disease syndrome; and immunodeficiency 21. Orthologous to several human genes including GATA3 (GATA binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    84F1-84F1; 3-48 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8147368..8181444, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3973090..4007166, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene transfer RNA:Arginine-ACG 1-10 Neighboring gene transfer RNA:Arginine-ACG 1-9 Neighboring gene long non-coding RNA:CR43302 Neighboring gene long non-coding RNA:CR43303

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single-cell RNA sequencing in Drosophila: Technologies and applications. Li H. Wiley Interdiscip Rev Dev Biol, 2021 Sep. PMID 32940008, Free PMC Article
    2. A combinatorial code of transcription factors specifies subtypes of visual motion-sensing neurons in Drosophila. Hörmann N, et al. Development, 2020 May 13. PMID 32238425, Free PMC Article
    3. Two forms of type IV zinc-finger motif and their kingdom-specific distribution between the flora, fauna and fungi. Teakle GR, et al. Trends Biochem Sci, 1998 Mar. PMID 9581501
    4. Expression of a Drosophila GATA transcription factor in multiple tissues in the developing embryos. Identification of homozygous lethal mutants with P-element insertion at the promoter region. Lin WH, et al. J Biol Chem, 1995 Oct 20. PMID 7559649
    5. A GATA/homeodomain transcriptional code regulates axon guidance through the Unc-5 receptor. Zarin AA, et al. Development, 2012 May. PMID 22461564

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dGATAe and grn expression are independent of each other; dGATAe and grn are not responsible for setting the general embryonic midgut morphology; results clarify the expression patterns and function of the GATA factor genes expressed in the embryonic midgut
      Title: GATA factor genes in the Drosophila midgut embryo.
    2. Grain is necessary for neuronal cell fate specification
      Title: Neuronal Cell Fate Specification by the Convergence of Different Spatiotemporal Cues on a Common Terminal Selector Cascade.
    3. Data strongly suggests that the eve-grn transcriptional code controls axon guidance, in part, by regulating the level of unc-5 expression.
      Title: A GATA/homeodomain transcriptional code regulates axon guidance through the Unc-5 receptor.
    4. An eve-->grn-->zfh1 genetic cascade is unique to one of the intersegmental motoneurons, the aCC.
      Title: Specification of Drosophila aCC motoneuron identity by a genetic cascade involving even-skipped, grain and zfh1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    grain
    Names
    CG9656-PA
    CG9656-PB
    CG9656-PC
    GATA-factor-c
    grn-PA
    grn-PB
    grn-PC
    lethal(3)84Fa

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8147368..8181444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169206.3 → NP_731211.1  grain, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731211.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91623, Q9VHV4
      Related
      FBpp0081304
      Conserved Domains (2) summary
      smart00401
      Location:316 → 365
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:320 → 370
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

    2. NM_001144554.3 → NP_001138026.1  grain, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138026.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0V4
      Conserved Domains (2) summary
      smart00401
      Location:529 → 578
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:533 → 583
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

    3. NM_001275437.2 → NP_001262366.1  grain, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262366.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFB6
      Conserved Domains (2) summary
      smart00401
      Location:529 → 578
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:533 → 583
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFB6 A0A0B4KFB6
    B7Z0V4 B7Z0V4
    P91623.1 P91623

    Gene LinkOut

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