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Conserved domains on  [gi|221378310|ref|NP_001138026|]
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grain, isoform B [Drosophila melanogaster]

Protein Classification

GATA-type transcription factor( domain architecture ID 10078896)

GATA-type transcription factor binds to the DNA consensus sequence [AT]GATA[AG] and may function as a transcription factor/regulator

CATH:  3.30.50.10
Gene Ontology:  GO:0003700|GO:0006357|GO:0008270|GO:0043565
PubMed:  31574210
SCOP:  4003617

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 533-583 6.12e-20

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 83.58  E-value: 6.12e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 221378310 533 SCANCKTTTTTLWRRN-ASGEPVCNACGLYYKLHNVNRPLTMKKEG-IQTRNR 583
Cdd:cd00202    1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNR 53
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 473-517 6.35e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 80.88  E-value: 6.35e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 221378310 473 ECVNCGATSTPLWRRDG-TGHYLCNACGLYYKMNGQNRPLIKPKRR 517
Cdd:cd00202    1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKD 46
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 533-583 6.12e-20

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 83.58  E-value: 6.12e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 221378310 533 SCANCKTTTTTLWRRN-ASGEPVCNACGLYYKLHNVNRPLTMKKEG-IQTRNR 583
Cdd:cd00202    1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNR 53
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 473-517 6.35e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 80.88  E-value: 6.35e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 221378310 473 ECVNCGATSTPLWRRDG-TGHYLCNACGLYYKMNGQNRPLIKPKRR 517
Cdd:cd00202    1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKD 46
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
529-578 1.19e-18

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 79.77  E-value: 1.19e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 221378310   529 RAGTSCANCKTTTTTLWRRNASGE-PVCNACGLYYKLHNV-NRPLTMKKEGI 578
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDGI 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
470-517 4.65e-16

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 72.45  E-value: 4.65e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 221378310   470 EGRECVNCGATSTPLWRRDGTGH-YLCNACGLYYKMNGQ-NRPLIKPKRR 517
Cdd:smart00401   2 SGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDG 51
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 474-508 2.13e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 64.65  E-value: 2.13e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 221378310  474 CVNCGATSTPLWRRDGTGHY-LCNACGLYYKMNGQN 508
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 534-568 4.22e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 63.49  E-value: 4.22e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 221378310  534 CANCKTTTTTLWRRNASGEP-VCNACGLYYKLHNVN 568
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
533-583 7.01e-09

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 58.73  E-value: 7.01e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 221378310 533 SCANCKTTTTTLWRR---NASGEPV--CNACGLYYKLHNVNR-PLTMKKEGIQTRNR 583
Cdd:COG5641  160 VCSNCKTTSTPLWRRassESSLPGNnlCNACGLYLKLHGSPRaPISLKSDSIKSRSS 216
PRK14892 PRK14892
putative transcription elongation factor Elf1; Provisional
 458-505 2.97e-03

putative transcription elongation factor Elf1; Provisional


Pssm-ID: 184886  Cd Length: 99  Bit Score: 37.73  E-value: 2.97e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 221378310 458 VKPVRTKPRTSaegrECVNCGATSTPLWRRDGTGHYLCNACGLYYKMN 505
Cdd:PRK14892  12 IRPKPKLPKIF----ECPRCGKVSISVKIKKNIAIITCGNCGLYTEFE 55
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 533-583 6.12e-20

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 83.58  E-value: 6.12e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 221378310 533 SCANCKTTTTTLWRRN-ASGEPVCNACGLYYKLHNVNRPLTMKKEG-IQTRNR 583
Cdd:cd00202    1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNR 53
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 473-517 6.35e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 80.88  E-value: 6.35e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 221378310 473 ECVNCGATSTPLWRRDG-TGHYLCNACGLYYKMNGQNRPLIKPKRR 517
Cdd:cd00202    1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKD 46
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
529-578 1.19e-18

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 79.77  E-value: 1.19e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 221378310   529 RAGTSCANCKTTTTTLWRRNASGE-PVCNACGLYYKLHNV-NRPLTMKKEGI 578
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDGI 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
470-517 4.65e-16

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 72.45  E-value: 4.65e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 221378310   470 EGRECVNCGATSTPLWRRDGTGH-YLCNACGLYYKMNGQ-NRPLIKPKRR 517
Cdd:smart00401   2 SGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDG 51
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 474-508 2.13e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 64.65  E-value: 2.13e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 221378310  474 CVNCGATSTPLWRRDGTGHY-LCNACGLYYKMNGQN 508
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 534-568 4.22e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 63.49  E-value: 4.22e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 221378310  534 CANCKTTTTTLWRRNASGEP-VCNACGLYYKLHNVN 568
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
533-583 7.01e-09

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 58.73  E-value: 7.01e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 221378310 533 SCANCKTTTTTLWRR---NASGEPV--CNACGLYYKLHNVNR-PLTMKKEGIQTRNR 583
Cdd:COG5641  160 VCSNCKTTSTPLWRRassESSLPGNnlCNACGLYLKLHGSPRaPISLKSDSIKSRSS 216
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
452-583 6.29e-08

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 55.65  E-value: 6.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221378310 452 GSNCLdvKPVRTKPRTSAEGRECVNCG-ATSTPLWRR-DGTGHYLCNACGLYYKMNGQNRPLIKpkrrltlQSLQSaAKR 529
Cdd:COG5641  280 GSTSL--QPVSTPKLVLPSDKKRSTLTtSTATPLWRRtSDKSSFSCNASGSALKPPGSKRPLLP-------KPDPN-SKR 349

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 221378310 530 AGTSCANCKTTTTTLWRrnaSGEPVCNACGLYYKLHNVNRPLTMKKEGIQTRNR 583
Cdd:COG5641  350 SNATCMNCSSTPTNKIL---SPPTTSNSPGAQVKLPNQTRSTGATKKKITRRRM 400
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
468-571 1.05e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 54.88  E-value: 1.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221378310 468 SAEGRECVNCGATSTPLWRRD-----GTGHYLCNACGLYYKMNGQNRPLIKPKRRLTLQSLQ---------SAAKRAGTS 533
Cdd:COG5641  155 SNQPHVCSNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRSSrsshnnndsNGENANTES 234

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 221378310 534 CANCK-TTTTTLWRRNASGEPV-CNACGLYYKLHNVNRPL 571
Cdd:COG5641  235 IGNSSaSKLTKSWEERPQGRQLlSDAGSLSPRSNNPKSPL 274
PRK14892 PRK14892
putative transcription elongation factor Elf1; Provisional
 458-505 2.97e-03

putative transcription elongation factor Elf1; Provisional


Pssm-ID: 184886  Cd Length: 99  Bit Score: 37.73  E-value: 2.97e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 221378310 458 VKPVRTKPRTSaegrECVNCGATSTPLWRRDGTGHYLCNACGLYYKMN 505
Cdd:PRK14892  12 IRPKPKLPKIF----ECPRCGKVSISVKIKKNIAIITCGNCGLYTEFE 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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