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    Snrpc small nuclear ribonucleoprotein polypeptide C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361808, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Snrpcprovided by RGD
    Official Full Name
    small nuclear ribonucleoprotein polypeptide Cprovided by RGD
    Primary source
    RGD:1306065
    See related
    EnsemblRapid:ENSRNOG00000000493 AllianceGenome:RGD:1306065
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    U1C; U1-C; Snrp1c
    Summary
    Enables U1 snRNP binding activity. Predicted to be involved in mRNA 5'-splice site recognition and spliceosomal snRNP assembly. Part of U1 snRNP. Human ortholog(s) of this gene implicated in connective tissue disease; mixed connective tissue disease; and systemic lupus erythematosus. Orthologous to human SNRPC (small nuclear ribonucleoprotein polypeptide C). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Thymus (RPKM 158.2), Testes (RPKM 131.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Snrpc in Genome Data Viewer
    Location:
    20p12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (5890229..5908410)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (5888453..5906638)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (7409401..7427581)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene SAM pointed domain containing ets transcription factor Neighboring gene inflammation and lipid regulator with UBA-like and NBR1-like domains Neighboring gene uncharacterized LOC134483861 Neighboring gene small nucleolar RNA SNORA26 Neighboring gene bridge-like lipid transfer protein family member 3A Neighboring gene TATA-box binding protein associated factor 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Immunological analysis of pulmonary hypertension in connective tissue diseases. Nishimaki T, et al. J Rheumatol, 1999 Nov. PMID 10555891
    2. Distinctive immune response patterns of human and murine autoimmune sera to U1 small nuclear ribonucleoprotein C protein. Satoh M, et al. J Clin Invest, 1996 Jun 1. PMID 8647956, Free PMC Article
    3. Protein stoichiometry of a multiprotein complex, the human spliceosomal U1 small nuclear ribonucleoprotein: absolute quantification using isotope-coded tags and mass spectrometry. Hochleitner EO, et al. J Biol Chem, 2005 Jan 28. PMID 15525645
    4. The structure and biochemical properties of the human spliceosomal protein U1C. Muto Y, et al. J Mol Biol, 2004 Jul 30. PMID 15312772
    5. Human monoclonal autoantibody fragments from combinatorial antibody libraries directed to the U1snRNP associated U1C protein; epitope mapping, immunolocalization and V-gene usage. Hoet RM, et al. Mol Immunol, 1998 Nov. PMID 10068039

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables U1 snRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables U1 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables U1 snRNP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pre-mRNA 5'-splice site binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA 5'-splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA 5'-splice site recognition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spliceosomal snRNP assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal snRNP assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U1 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U1 snRNP IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of U1 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U1 snRNP ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of U2-type prespliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of commitment complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    U1 small nuclear ribonucleoprotein C
    Names
    U1 snRNP C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271040.1 → NP_001257969.1  U1 small nuclear ribonucleoprotein C

      See identical proteins and their annotated locations for NP_001257969.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      D3ZCL3
      UniProtKB/TrEMBL
      A0A8I6A3U2, A6HD02
      Related
      ENSRNOP00000000586.6, ENSRNOT00000000586.9
      Conserved Domains (1) summary
      pfam06220
      Location:1 → 38
      zf-U1; U1 zinc finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      5890229..5908410
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098816.2 → XP_038954744.1  U1 small nuclear ribonucleoprotein C isoform X2

    2. XM_063279219.1 → XP_063135289.1  U1 small nuclear ribonucleoprotein C isoform X2

    3. XM_063279217.1 → XP_063135287.1  U1 small nuclear ribonucleoprotein C isoform X1

      UniProtKB/TrEMBL
      A0A8I6AJC1

    4. XM_063279218.1 → XP_063135288.1  U1 small nuclear ribonucleoprotein C isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZCL3.1 GenPept UniProtKB/Swiss-Prot:D3ZCL3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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