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    Dhx29 DExH-box helicase 29 [ Mus musculus (house mouse) ]

    Gene ID: 218629, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Dhx29provided by MGI
    Official Full Name
    DExH-box helicase 29provided by MGI
    Primary source
    MGI:MGI:2145374
    See related
    Ensembl:ENSMUSG00000042426 AllianceGenome:MGI:2145374
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ddxx; 3732415M03; E130202M19Rik
    Summary
    Predicted to enable several functions, including nucleic acid binding activity; ribonucleoside triphosphate phosphatase activity; and ribosomal small subunit binding activity. Predicted to be involved in formation of translation preinitiation complex and ribosome assembly. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and hemolymphoid system gland. Orthologous to human DHX29 (DExH-box helicase 29). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.2), CNS E18 (RPKM 5.8) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dhx29 in Genome Data Viewer
    Location:
    13 D2.2; 13 63.93 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (113063976..113105968)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (112927680..112969432)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35701 Neighboring gene predicted gene, 41067 Neighboring gene STARR-seq mESC enhancer starr_35702 Neighboring gene phospholipid phosphatase 1 Neighboring gene Mtr4 exosome RNA helicase Neighboring gene STARR-positive B cell enhancer ABC_E7290 Neighboring gene STARR-positive B cell enhancer ABC_E1469 Neighboring gene 40S ribosomal protein S13-like Neighboring gene multiciliate differentiation and DNA synthesis associated cell cycle protein Neighboring gene cyclin O

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins. Hémono M, et al. BMC Biol, 2022 Jan 10. PMID 35012549, Free PMC Article
    2. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
    3. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
    4. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
    5. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Gu J, et al. Cell Death Differ, 2023 Jul. PMID 37142655, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 
    • Transgenic (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal small subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal small subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in formation of translation preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in formation of translation preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic small ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic 43S preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic 43S preinitiation complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase Dhx29
    Names
    DEAH (Asp-Glu-Ala-His) box polypeptide 29
    DEAH box protein 29
    nucleic acid helicase DDXx
    NP_766182.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172594.3 → NP_766182.2  ATP-dependent RNA helicase Dhx29

      See identical proteins and their annotated locations for NP_766182.2

      Status: VALIDATED

      Source sequence(s)
      AK087450, BC038650, BC057112
      Consensus CDS
      CCDS26779.1
      UniProtKB/Swiss-Prot
      Q6PGC1, Q8BQJ4, Q8BT01, Q8C9B7, Q8C9H9
      Related
      ENSMUSP00000035244.6, ENSMUST00000038574.7
      Conserved Domains (5) summary
      smart00487
      Location:577 → 763
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:1055 → 1136
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:588 → 735
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00271
      Location:863 → 984
      Helicase_C; Helicase conserved C-terminal domain
      pfam07717
      Location:1178 → 1298
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      113063976..113105968
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004938025.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PGC1.1 GenPept UniProtKB/Swiss-Prot:Q6PGC1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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