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    Cdh11 cadherin 11 [ Mus musculus (house mouse) ]

    Gene ID: 12552, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cdh11provided by MGI
    Official Full Name
    cadherin 11provided by MGI
    Primary source
    MGI:MGI:99217
    See related
    Ensembl:ENSMUSG00000031673 AllianceGenome:MGI:99217
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cad11; OSF-4
    Summary
    This gene encodes a type II classical cadherin and preproprotein that is proteolytically processed to generate a mature protein product. This protein product is an integral membrane protein that mediates calcium-dependent cell-cell adhesion, specifically in the context of bone development. Homozygous knockout mice for this gene exhibit impaired synovium development and reduced bone density. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]
    Expression
    Biased expression in limb E14.5 (RPKM 39.5), CNS E11.5 (RPKM 18.9) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdh11 in Genome Data Viewer
    Location:
    8 D1; 8 50.44 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (103358727..103512125, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (102632095..102785493, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene myotubularin-related protein 12 pseudogene Neighboring gene predicted gene, 39233 Neighboring gene STARR-seq mESC enhancer starr_22482 Neighboring gene STARR-seq mESC enhancer starr_22483 Neighboring gene STARR-seq mESC enhancer starr_22484 Neighboring gene STARR-seq mESC enhancer starr_22485 Neighboring gene ribosomal protein, large, P0 pseudogene Neighboring gene VISTA enhancer mm40 Neighboring gene STARR-seq mESC enhancer starr_22486 Neighboring gene predicted gene, 32531

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Side-specific valvular endothelial-interstitial cell mechano-communication via cadherin-11. Johnson CL, et al. J Biomech, 2021 Apr 15. PMID 33636459, Free PMC Article
    2. Cadherin-11 in synovial lining formation and pathology in arthritis. Lee DM, et al. Science, 2007 Feb 16. PMID 17255475
    3. The adhesion molecule cadherin 11 is essential for acquisition of normal hearing ability through middle ear development in the mouse. Kiyama Y, et al. Lab Invest, 2018 Nov. PMID 29967341
    4. Cadherin-11 as a regulator of valve myofibroblast mechanobiology. Bowler MA, et al. Am J Physiol Heart Circ Physiol, 2018 Dec 1. PMID 30359089, Free PMC Article
    5. Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes. Chang SK, et al. J Clin Invest, 2017 Sep 1. PMID 28758901, Free PMC Article

    See all (142) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CADHERIN-11 regulation of myeloid phagocytes and autoimmune inflammation in murine lupus.
      Title: CADHERIN-11 regulation of myeloid phagocytes and autoimmune inflammation in murine lupus.
    2. Let-7c-3p suppresses lens epithelial-mesenchymal transition by inhibiting cadherin-11 expression in fibrotic cataract.
      Title: Let-7c-3p suppresses lens epithelial-mesenchymal transition by inhibiting cadherin-11 expression in fibrotic cataract.
    3. Cadherin-11 and Its Role in Tissue Fibrosis.
      Title: Cadherin-11 and Its Role in Tissue Fibrosis.
    4. Cadherin-11 Regulates Macrophage Development and Function.
      Title: Cadherin-11 Regulates Macrophage Development and Function.
    5. Dimerization of Cadherin-11 involves multi-site coupled unfolding and strand swapping.
      Title: Dimerization of Cadherin-11 involves multi-site coupled unfolding and strand swapping.
    6. Association of CDH11 with Autism Spectrum Disorder Revealed by Matched-gene Co-expression Analysis and Mouse Behavioral Studies.
      Title: Association of CDH11 with Autism Spectrum Disorder Revealed by Matched-gene Co-expression Analysis and Mouse Behavioral Studies.
    7. Impaired macrophage trafficking and increased helper T-cell recruitment with loss of cadherin-11 in atherosclerotic immune response.
      Title: Impaired macrophage trafficking and increased helper T-cell recruitment with loss of cadherin-11 in atherosclerotic immune response.
    8. Regulation of Neural Circuit Development by Cadherin-11 Provides Implications for Autism.
      Title: Regulation of Neural Circuit Development by Cadherin-11 Provides Implications for Autism.
    9. Cadherin 11 Promotes Immunosuppression and Extracellular Matrix Deposition to Support Growth of Pancreatic Tumors and Resistance to Gemcitabine in Mice.
      Title: Cadherin 11 Promotes Immunosuppression and Extracellular Matrix Deposition to Support Growth of Pancreatic Tumors and Resistance to Gemcitabine in Mice.
    10. Side-specific valvular endothelial-interstitial cell mechano-communication via cadherin-11.
      Title: Side-specific valvular endothelial-interstitial cell mechano-communication via cadherin-11.
    Submit: New GeneRIF Correction See all GeneRIFs (46)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC25339

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adherens junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion mediated by cadherin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion via plasma-membrane adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell-cell junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within corticospinal tract morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in focal adhesion assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cadherin-11
    Names
    OB-cadherin
    osteoblast cadherin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416447.1 → NP_001403376.1  cadherin-11 precursor

      Status: VALIDATED

      Source sequence(s)
      AC105256, AC141869
      UniProtKB/Swiss-Prot
      P55288

    2. NM_009866.6 → NP_033996.4  cadherin-11 preproprotein

      See identical proteins and their annotated locations for NP_033996.4

      Status: VALIDATED

      Source sequence(s)
      AC105256, AC141869
      Consensus CDS
      CCDS22571.1
      UniProtKB/Swiss-Prot
      P55288
      UniProtKB/TrEMBL
      Q8C7Q6
      Related
      ENSMUSP00000074681.4, ENSMUST00000075190.5
      Conserved Domains (3) summary
      cd11304
      Location:163 → 264
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:79 → 157
      CA; Cadherin repeats
      pfam01049
      Location:641 → 789
      Cadherin_C; Cadherin cytoplasmic region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      103358727..103512125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530624.3 → XP_006530687.1  cadherin-11 isoform X1

      See identical proteins and their annotated locations for XP_006530687.1

      UniProtKB/Swiss-Prot
      P55288
      UniProtKB/TrEMBL
      Q8C7Q6
      Conserved Domains (3) summary
      cd11304
      Location:163 → 264
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:79 → 157
      CA; Cadherin repeats
      pfam01049
      Location:641 → 789
      Cadherin_C; Cadherin cytoplasmic region

    2. XM_030243272.2 → XP_030099132.1  cadherin-11 isoform X1

      UniProtKB/Swiss-Prot
      P55288
      UniProtKB/TrEMBL
      Q8C7Q6
      Conserved Domains (3) summary
      cd11304
      Location:163 → 264
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:79 → 157
      CA; Cadherin repeats
      pfam01049
      Location:641 → 789
      Cadherin_C; Cadherin cytoplasmic region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55288.1 GenPept UniProtKB/Swiss-Prot:P55288

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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