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    SHMT1 serine hydroxymethyltransferase 1 [ Rhinolophus ferrumequinum (greater horseshoe bat) ]

    Gene ID: 117013027, updated on 30-Mar-2024

    Summary

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    Gene symbol
    SHMT1
    Gene description
    serine hydroxymethyltransferase 1
    See related
    EnsemblRapid:ENSRFEG00010005662
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rhinolophus ferrumequinum
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yinpterochiroptera; Rhinolophoidea; Rhinolophidae; Rhinolophinae; Rhinolophus
    Orthologs
    human mouse all
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    Genomic context

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    See SHMT1 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_02 current mRhiFer1_v1.p (GCF_004115265.2) 21 NC_046304.1 (526915..556467)

    Chromosome 21 - NC_046304.1Genomic Context describing neighboring genes Neighboring gene phosphoribosyl pyrophosphate synthetase associated protein 2 Neighboring gene ras-related protein Rab-11A-like Neighboring gene SMCR8-C9orf72 complex subunit Neighboring gene DNA topoisomerase III alpha

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_046304.1 Chromosome 21 Reference mRhiFer1_v1.p

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cobalt ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables glycine hydroxymethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables mRNA 5'-UTR binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables mRNA regulatory element binding translation repressor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-serine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in folic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in glycine biosynthetic process from serine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in purine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine hydroxymethyltransferase, cytosolic

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_004115265.2-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRhiFer1_v1.p

    Genomic

    1. NC_046304.1 Reference mRhiFer1_v1.p

      Range
      526915..556467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_033089667.1 → XP_032945558.1  serine hydroxymethyltransferase, cytosolic

      UniProtKB/TrEMBL
      A0A671E4Y6, A0A7J7TFV9
      Related
      ENSRFEP00010008291.1, ENSRFET00010009117.2
      Conserved Domains (1) summary
      PLN03226
      Location:24 → 481
      PLN03226; serine hydroxymethyltransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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