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Conserved domains on  [gi|1823852584|ref|XP_032945558|]
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serine hydroxymethyltransferase, cytosolic [Rhinolophus ferrumequinum]

Protein Classification

serine hydroxymethyltransferase( domain architecture ID 11477583)

serine hydroxymethyltransferase catalyzes the reversible, simultaneous conversions of L-serine to glycine (retro-aldol cleavage) and tetrahydrofolate to 5,10-methylenetetrahydrofolate (hydrolysis)

CATH:  3.90.1150.10|3.40.640.10
EC:  2.1.2.1
Gene Ontology:  GO:0004372|GO:0030170|GO:0070905|GO:0008270|GO:0019264|GO:0048027
PubMed:  12686103|2201683|10800595|10673430

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03226 PLN03226
serine hydroxymethyltransferase; Provisional
 24-481 0e+00

serine hydroxymethyltransferase; Provisional


:

Pssm-ID: 215639  Cd Length: 475  Bit Score: 831.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584  24 QPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFVDELEILCQKRALQV 103
Cdd:PLN03226   13 APLEEVDPEIADIIEKEKRRQWKGLELIASENFTSRAVMEALGSCLTNKYSEGLPGARYYGGNEYIDQIETLCQKRALEA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 104 YDLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTEKKKISATSIFFESMPYKVNPETGYINY 183
Cdd:PLN03226   93 FRLDPEKWGVNVQPLSGSPANFAVYTALLQPHDRIMGLDLPHGGHLSHGYQTDGKKISATSIYFESMPYRLDESTGLIDY 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 184 DQLEENARLFHPKLIIAGTSCYSRNLDYARLRRIADDNGAYLMADMAHISGLVAAGVVPSPFEHCHVVSTTTHKTLRGCR 263
Cdd:PLN03226  173 DKLEKKAMLFRPKLIIAGASAYPRDWDYARMRKIADKVGALLMCDMAHISGLVAAQEAASPFEYCDVVTTTTHKSLRGPR 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 264 AGMIFYRRGVRSVDpKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTPEFRIYQRQVVANSRALAATLM 343
Cdd:PLN03226  253 GGMIFFRKGPKPPK-GQGEGAVYDYEDKINFAVFPGLQGGPHNHTIAALAVALKQAMTPEFKAYQKQVKANAAALANRLM 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 344 ELGYTVVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDKSALRPSGLRLGTPALTSRGLLEKEFQKVAH 423
Cdd:PLN03226  332 SKGYKLVTGGTDNHLVLWDLRPLGLTGSRVEKVLDLAHITLNKNAVPGDSSALVPGGVRIGTPAMTSRGLVEKDFEKVAE 411

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1823852584 424 FIHRGIELTLQLQSDVGARatLKEFKEKLAGDEkHRSAIRALREEVESFASLFPLPGL 481
Cdd:PLN03226  412 FLHRAVTIALKIQKEHGKK--LKDFKKGLESND-FSKDIEALRAEVEEFATSFPMPGF 466
 
Name Accession Description Interval E-value
PLN03226 PLN03226
serine hydroxymethyltransferase; Provisional
 24-481 0e+00

serine hydroxymethyltransferase; Provisional


Pssm-ID: 215639  Cd Length: 475  Bit Score: 831.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584  24 QPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFVDELEILCQKRALQV 103
Cdd:PLN03226   13 APLEEVDPEIADIIEKEKRRQWKGLELIASENFTSRAVMEALGSCLTNKYSEGLPGARYYGGNEYIDQIETLCQKRALEA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 104 YDLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTEKKKISATSIFFESMPYKVNPETGYINY 183
Cdd:PLN03226   93 FRLDPEKWGVNVQPLSGSPANFAVYTALLQPHDRIMGLDLPHGGHLSHGYQTDGKKISATSIYFESMPYRLDESTGLIDY 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 184 DQLEENARLFHPKLIIAGTSCYSRNLDYARLRRIADDNGAYLMADMAHISGLVAAGVVPSPFEHCHVVSTTTHKTLRGCR 263
Cdd:PLN03226  173 DKLEKKAMLFRPKLIIAGASAYPRDWDYARMRKIADKVGALLMCDMAHISGLVAAQEAASPFEYCDVVTTTTHKSLRGPR 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 264 AGMIFYRRGVRSVDpKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTPEFRIYQRQVVANSRALAATLM 343
Cdd:PLN03226  253 GGMIFFRKGPKPPK-GQGEGAVYDYEDKINFAVFPGLQGGPHNHTIAALAVALKQAMTPEFKAYQKQVKANAAALANRLM 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 344 ELGYTVVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDKSALRPSGLRLGTPALTSRGLLEKEFQKVAH 423
Cdd:PLN03226  332 SKGYKLVTGGTDNHLVLWDLRPLGLTGSRVEKVLDLAHITLNKNAVPGDSSALVPGGVRIGTPAMTSRGLVEKDFEKVAE 411

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1823852584 424 FIHRGIELTLQLQSDVGARatLKEFKEKLAGDEkHRSAIRALREEVESFASLFPLPGL 481
Cdd:PLN03226  412 FLHRAVTIALKIQKEHGKK--LKDFKKGLESND-FSKDIEALRAEVEEFATSFPMPGF 466
SHMT pfam00464
Serine hydroxymethyltransferase;
26-425 0e+00

Serine hydroxymethyltransferase;


Pssm-ID: 395372  Cd Length: 399  Bit Score: 784.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584  26 LKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFVDELEILCQKRALQVYD 105
Cdd:pfam00464   1 LEDSDPEVFDIIKKEKERQREGIELIASENFTSRAVMEALGSVLTNKYSEGYPGKRYYGGCEHVDEIETLCQDRALEAFG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 106 LDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTEKKKISATSIFFESMPYKVNPETGYINYDQ 185
Cdd:pfam00464  81 LDPAKWGVNVQPLSGSPANLAVYTALLEPGDRIMGLDLPHGGHLTHGYPVNSKKISASSKFFESMPYGVDPETGYIDYDQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 186 LEENARLFHPKLIIAGTSCYSRNLDYARLRRIADDNGAYLMADMAHISGLVAAGVVPSPFEHCHVVSTTTHKTLRGCRAG 265
Cdd:pfam00464 161 LEKNAKLFRPKLIVAGTSAYSRLIDYARFREIADEVGAYLMVDMAHISGLVAAGVIPSPFPYADVVTTTTHKTLRGPRGG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 266 MIFYRRGVRSVDpKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTPEFRIYQRQVVANSRALAATLMEL 345
Cdd:pfam00464 241 MIFYRKGVKSVD-KTGKEILYELEKKINSAVFPGLQGGPHNHVIAAKAVALKQALTPEFKEYQQQVVKNAKALAEALTER 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 346 GYTVVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDKSALRPSGLRLGTPALTSRGLLEKEFQKVAHFI 425
Cdd:pfam00464 320 GYKLVSGGTDNHLVLVDLRPKGLDGARAEKVLEAANITANKNTIPGDKSAFVPSGLRLGTPALTSRGFGEADFEKVAGFI 399
SHMT cd00378
Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate ...
 27-452 0e+00

Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl group of N5, N10-methylene tetrahydrofolate to glycine resulting in the formation of serine and tetrahydrofolate. Both eukaryotic and prokaryotic SHMT enzymes form tight obligate homodimers; the mammalian enzyme forms a homotetramer comprising four pyridoxal phosphate-bound active sites.


Pssm-ID: 99733  Cd Length: 402  Bit Score: 658.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584  27 KDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFVDELEILCQKRALQVYDL 106
Cdd:cd00378     1 ADVDPEIAEIIKKENERQRETLELIASENFTSPAVMEAMGSDLTNKYAEGYPGKRYYGGCEYVDEIEDLAIERAKKLFGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 107 DpqcwGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTekkKISATSIFFESMPYKVNPETGYINYDQL 186
Cdd:cd00378    81 E----YANVQPHSGSQANLAVYFALLEPGDTIMGLDLSHGGHLTHGSFT---KVSASGKLFESVPYGVDPETGLIDYDAL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 187 EENARLFHPKLIIAGTSCYSRNLDYARLRRIADDNGAYLMADMAHISGLVAAGVVPSPFEHCHVVSTTTHKTLRGCRAGM 266
Cdd:cd00378   154 EKMALEFKPKLIVAGASAYPRPIDFKRFREIADEVGAYLLVDMAHVAGLVAGGVFPNPLPGADVVTTTTHKTLRGPRGGL 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 267 IFYRRGvrsvdpktgkeilyNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTPEFRIYQRQVVANSRALAATLMELG 346
Cdd:cd00378   234 ILTRKG--------------ELAKKINSAVFPGLQGGPHLHVIAAKAVALKEALEPEFKAYAKQVVENAKALAEALKERG 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 347 YTVVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDKS-ALRPSGLRLGTPALTSRGLLEKEFQKVAHFI 425
Cdd:cd00378   300 FKVVSGGTDNHLVLVDLRPKGITGKAAEDALEEAGITVNKNTLPWDPSsPFVPSGIRIGTPAMTTRGMGEEEMEEIADFI 379

                         410       420
                  ....*....|....*....|....*..
gi 1823852584 426 HRGIELTlqlqSDVGARATLKEFKEKL 452
Cdd:cd00378   380 ARALKDA----EDVAVAEEVRKEVAEL 402
GlyA COG0112
Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Glycine/serine ...
 22-480 0e+00

Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Glycine/serine hydroxymethyltransferase is part of the Pathway/BioSystem: Serine biosynthesis


Pssm-ID: 439882  Cd Length: 414  Bit Score: 603.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584  22 MAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFVDELEILCQKRAL 101
Cdd:COG0112     1 MLSSLAEVDPEIAEAIEKELERQEEGIELIASENFVSPAVLEAQGSVLTNKYAEGYPGKRYYGGCEYVDEVEQLAIERAK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 102 QVYDLDpqcwGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGfmtekKKISATSIFFESMPYKVNPETGYI 181
Cdd:COG0112    81 ELFGAE----HANVQPHSGSQANLAVYFALLKPGDTILGMDLAHGGHLTHG-----SPVNFSGKGYNVVSYGVDPETGLI 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 182 NYDQLEENARLFHPKLIIAGTSCYSRNLDYARLRRIADDNGAYLMADMAHISGLVAAGVVPSPFEHCHVVSTTTHKTLRG 261
Cdd:COG0112   152 DYDEVRKLALEHKPKLIIAGASAYPRPIDFARFREIADEVGAYLMVDMAHIAGLVAGGLHPSPVPGADVVTTTTHKTLRG 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 262 CRAGMIFyrrgvrsvdpkTGKEilynLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTPEFRIYQRQVVANSRALAAT 341
Cdd:COG0112   232 PRGGLIL-----------CNEE----LAKKIDSAVFPGLQGGPLMHVIAAKAVAFKEALTPEFKEYAKQVVKNAKALAEA 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 342 LMELGYTVVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGD-KSALRPSGLRLGTPALTSRGLLEKEFQK 420
Cdd:COG0112   297 LAERGFRVVSGGTDNHLVLVDLRSKGLTGKEAEKALERAGITVNKNAIPFDpRSPFVTSGIRIGTPAVTTRGMKEAEMEE 376

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 421 VAHFIHRGIEltlqlqsdvgaratlkefkeklagDEKHRSAIRALREEVESFASLFPLPG 480
Cdd:COG0112   377 IAELIADVLD------------------------NPEDEAVLAEVREEVKELCKRFPLYP 412
 
Name Accession Description Interval E-value
PLN03226 PLN03226
serine hydroxymethyltransferase; Provisional
 24-481 0e+00

serine hydroxymethyltransferase; Provisional


Pssm-ID: 215639  Cd Length: 475  Bit Score: 831.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584  24 QPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFVDELEILCQKRALQV 103
Cdd:PLN03226   13 APLEEVDPEIADIIEKEKRRQWKGLELIASENFTSRAVMEALGSCLTNKYSEGLPGARYYGGNEYIDQIETLCQKRALEA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 104 YDLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTEKKKISATSIFFESMPYKVNPETGYINY 183
Cdd:PLN03226   93 FRLDPEKWGVNVQPLSGSPANFAVYTALLQPHDRIMGLDLPHGGHLSHGYQTDGKKISATSIYFESMPYRLDESTGLIDY 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 184 DQLEENARLFHPKLIIAGTSCYSRNLDYARLRRIADDNGAYLMADMAHISGLVAAGVVPSPFEHCHVVSTTTHKTLRGCR 263
Cdd:PLN03226  173 DKLEKKAMLFRPKLIIAGASAYPRDWDYARMRKIADKVGALLMCDMAHISGLVAAQEAASPFEYCDVVTTTTHKSLRGPR 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 264 AGMIFYRRGVRSVDpKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTPEFRIYQRQVVANSRALAATLM 343
Cdd:PLN03226  253 GGMIFFRKGPKPPK-GQGEGAVYDYEDKINFAVFPGLQGGPHNHTIAALAVALKQAMTPEFKAYQKQVKANAAALANRLM 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 344 ELGYTVVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDKSALRPSGLRLGTPALTSRGLLEKEFQKVAH 423
Cdd:PLN03226  332 SKGYKLVTGGTDNHLVLWDLRPLGLTGSRVEKVLDLAHITLNKNAVPGDSSALVPGGVRIGTPAMTSRGLVEKDFEKVAE 411

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1823852584 424 FIHRGIELTLQLQSDVGARatLKEFKEKLAGDEkHRSAIRALREEVESFASLFPLPGL 481
Cdd:PLN03226  412 FLHRAVTIALKIQKEHGKK--LKDFKKGLESND-FSKDIEALRAEVEEFATSFPMPGF 466
SHMT pfam00464
Serine hydroxymethyltransferase;
26-425 0e+00

Serine hydroxymethyltransferase;


Pssm-ID: 395372  Cd Length: 399  Bit Score: 784.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584  26 LKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFVDELEILCQKRALQVYD 105
Cdd:pfam00464   1 LEDSDPEVFDIIKKEKERQREGIELIASENFTSRAVMEALGSVLTNKYSEGYPGKRYYGGCEHVDEIETLCQDRALEAFG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 106 LDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTEKKKISATSIFFESMPYKVNPETGYINYDQ 185
Cdd:pfam00464  81 LDPAKWGVNVQPLSGSPANLAVYTALLEPGDRIMGLDLPHGGHLTHGYPVNSKKISASSKFFESMPYGVDPETGYIDYDQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 186 LEENARLFHPKLIIAGTSCYSRNLDYARLRRIADDNGAYLMADMAHISGLVAAGVVPSPFEHCHVVSTTTHKTLRGCRAG 265
Cdd:pfam00464 161 LEKNAKLFRPKLIVAGTSAYSRLIDYARFREIADEVGAYLMVDMAHISGLVAAGVIPSPFPYADVVTTTTHKTLRGPRGG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 266 MIFYRRGVRSVDpKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTPEFRIYQRQVVANSRALAATLMEL 345
Cdd:pfam00464 241 MIFYRKGVKSVD-KTGKEILYELEKKINSAVFPGLQGGPHNHVIAAKAVALKQALTPEFKEYQQQVVKNAKALAEALTER 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 346 GYTVVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDKSALRPSGLRLGTPALTSRGLLEKEFQKVAHFI 425
Cdd:pfam00464 320 GYKLVSGGTDNHLVLVDLRPKGLDGARAEKVLEAANITANKNTIPGDKSAFVPSGLRLGTPALTSRGFGEADFEKVAGFI 399
PTZ00094 PTZ00094
serine hydroxymethyltransferase; Provisional
 24-481 0e+00

serine hydroxymethyltransferase; Provisional


Pssm-ID: 240264  Cd Length: 452  Bit Score: 773.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584  24 QPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFVDELEILCQKRALQV 103
Cdd:PTZ00094   13 QSLKEADPELYELIEKEKERQIEGLELIASENFTSRAVLECLGSCFTNKYAEGLPGNRYYGGNEVVDKIENLCQKRALEA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 104 YDLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTEKKKISATSIFFESMPYKVNPEtGYINY 183
Cdd:PTZ00094   93 FGLDPEEWGVNVQPYSGSPANFAVYTALLQPHDRIMGLDLPSGGHLTHGFYTAKKKVSATSIYFESLPYQVNEK-GLIDY 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 184 DQLEENARLFHPKLIIAGTSCYSRNLDYARLRRIADDNGAYLMADMAHISGLVAAGVVPSPFEHCHVVSTTTHKTLRGCR 263
Cdd:PTZ00094  172 DKLEELAKAFRPKLIIAGASAYPRDIDYKRFREICDSVGAYLMADIAHTSGLVAAGVLPSPFPYADVVTTTTHKSLRGPR 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 264 AGMIFYRRGVRSvdpktgkeilyNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTPEFRIYQRQVVANSRALAATLM 343
Cdd:PTZ00094  252 SGLIFYRKKVKP-----------DIENKINEAVFPGLQGGPHNHQIAAIAVQLKEVQSPEWKEYAKQVLKNAKALAAALE 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 344 ELGYTVVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDKSALRPSGLRLGTPALTSRGLLEKEFQKVAH 423
Cdd:PTZ00094  321 KRGYDLVTGGTDNHLVLVDLRPFGITGSKMEKLLDAVNISVNKNTIPGDKSALNPSGVRLGTPALTTRGAKEKDFKFVAD 400

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1823852584 424 FIHRGIELTLQLQSDVGarATLKEFKEKLAGDEKhrsaIRALREEVESFASLFPLPGL 481
Cdd:PTZ00094  401 FLDRAVKLAQEIQKQVG--KKLVDFKKALEKNPE----LQKLRQEVVEFASQFPFPGI 452
SHMT cd00378
Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate ...
 27-452 0e+00

Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl group of N5, N10-methylene tetrahydrofolate to glycine resulting in the formation of serine and tetrahydrofolate. Both eukaryotic and prokaryotic SHMT enzymes form tight obligate homodimers; the mammalian enzyme forms a homotetramer comprising four pyridoxal phosphate-bound active sites.


Pssm-ID: 99733  Cd Length: 402  Bit Score: 658.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584  27 KDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFVDELEILCQKRALQVYDL 106
Cdd:cd00378     1 ADVDPEIAEIIKKENERQRETLELIASENFTSPAVMEAMGSDLTNKYAEGYPGKRYYGGCEYVDEIEDLAIERAKKLFGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 107 DpqcwGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTekkKISATSIFFESMPYKVNPETGYINYDQL 186
Cdd:cd00378    81 E----YANVQPHSGSQANLAVYFALLEPGDTIMGLDLSHGGHLTHGSFT---KVSASGKLFESVPYGVDPETGLIDYDAL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 187 EENARLFHPKLIIAGTSCYSRNLDYARLRRIADDNGAYLMADMAHISGLVAAGVVPSPFEHCHVVSTTTHKTLRGCRAGM 266
Cdd:cd00378   154 EKMALEFKPKLIVAGASAYPRPIDFKRFREIADEVGAYLLVDMAHVAGLVAGGVFPNPLPGADVVTTTTHKTLRGPRGGL 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 267 IFYRRGvrsvdpktgkeilyNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTPEFRIYQRQVVANSRALAATLMELG 346
Cdd:cd00378   234 ILTRKG--------------ELAKKINSAVFPGLQGGPHLHVIAAKAVALKEALEPEFKAYAKQVVENAKALAEALKERG 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 347 YTVVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDKS-ALRPSGLRLGTPALTSRGLLEKEFQKVAHFI 425
Cdd:cd00378   300 FKVVSGGTDNHLVLVDLRPKGITGKAAEDALEEAGITVNKNTLPWDPSsPFVPSGIRIGTPAMTTRGMGEEEMEEIADFI 379

                         410       420
                  ....*....|....*....|....*..
gi 1823852584 426 HRGIELTlqlqSDVGARATLKEFKEKL 452
Cdd:cd00378   380 ARALKDA----EDVAVAEEVRKEVAEL 402
GlyA COG0112
Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Glycine/serine ...
 22-480 0e+00

Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Glycine/serine hydroxymethyltransferase is part of the Pathway/BioSystem: Serine biosynthesis


Pssm-ID: 439882  Cd Length: 414  Bit Score: 603.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584  22 MAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFVDELEILCQKRAL 101
Cdd:COG0112     1 MLSSLAEVDPEIAEAIEKELERQEEGIELIASENFVSPAVLEAQGSVLTNKYAEGYPGKRYYGGCEYVDEVEQLAIERAK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 102 QVYDLDpqcwGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGfmtekKKISATSIFFESMPYKVNPETGYI 181
Cdd:COG0112    81 ELFGAE----HANVQPHSGSQANLAVYFALLKPGDTILGMDLAHGGHLTHG-----SPVNFSGKGYNVVSYGVDPETGLI 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 182 NYDQLEENARLFHPKLIIAGTSCYSRNLDYARLRRIADDNGAYLMADMAHISGLVAAGVVPSPFEHCHVVSTTTHKTLRG 261
Cdd:COG0112   152 DYDEVRKLALEHKPKLIIAGASAYPRPIDFARFREIADEVGAYLMVDMAHIAGLVAGGLHPSPVPGADVVTTTTHKTLRG 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 262 CRAGMIFyrrgvrsvdpkTGKEilynLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTPEFRIYQRQVVANSRALAAT 341
Cdd:COG0112   232 PRGGLIL-----------CNEE----LAKKIDSAVFPGLQGGPLMHVIAAKAVAFKEALTPEFKEYAKQVVKNAKALAEA 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 342 LMELGYTVVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGD-KSALRPSGLRLGTPALTSRGLLEKEFQK 420
Cdd:COG0112   297 LAERGFRVVSGGTDNHLVLVDLRSKGLTGKEAEKALERAGITVNKNAIPFDpRSPFVTSGIRIGTPAVTTRGMKEAEMEE 376

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 421 VAHFIHRGIEltlqlqsdvgaratlkefkeklagDEKHRSAIRALREEVESFASLFPLPG 480
Cdd:COG0112   377 IAELIADVLD------------------------NPEDEAVLAEVREEVKELCKRFPLYP 412
glyA PRK00011
serine hydroxymethyltransferase; Reviewed
 21-480 0e+00

serine hydroxymethyltransferase; Reviewed


Pssm-ID: 234571  Cd Length: 416  Bit Score: 595.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584  21 MMAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFVDELEILCQKRA 100
Cdd:PRK00011    1 FFMDNLAEYDPEIADAIEQELKRQEEHIELIASENFVSPAVMEAQGSVLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 101 LQVYDLDpqcwGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGfmtekKKISATSIFFESMPYKVNPETGY 180
Cdd:PRK00011   81 KELFGAE----YANVQPHSGSQANAAVYFALLKPGDTILGMDLAHGGHLTHG-----SPVNFSGKLYNVVSYGVDEETGL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 181 INYDQLEENARLFHPKLIIAGTSCYSRNLDYARLRRIADDNGAYLMADMAHISGLVAAGVVPSPFEHCHVVSTTTHKTLR 260
Cdd:PRK00011  152 IDYDEVEKLALEHKPKLIIAGASAYSRPIDFKRFREIADEVGAYLMVDMAHIAGLVAAGVHPSPVPHADVVTTTTHKTLR 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 261 GCRAGMIFYRrgvrsvDPKTGKEIlynlesliNSAVFPGLQGGPHNHAIAGVAVALKQAMTPEFRIYQRQVVANSRALAA 340
Cdd:PRK00011  232 GPRGGLILTN------DEELAKKI--------NSAVFPGIQGGPLMHVIAAKAVAFKEALEPEFKEYAQQVVKNAKALAE 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 341 TLMELGYTVVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGD-KSALRPSGLRLGTPALTSRGLLEKEFQ 419
Cdd:PRK00011  298 ALAERGFRVVSGGTDNHLVLVDLRSKGLTGKEAEAALEEANITVNKNAVPFDpRSPFVTSGIRIGTPAITTRGFKEAEMK 377

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1823852584 420 KVAHFIHRGIEltlqlqsDVGARATLKEfkeklagdekhrsairaLREEVESFASLFPLPG 480
Cdd:PRK00011  378 EIAELIADVLD-------NPDDEAVIEE-----------------VKEEVKELCKRFPLYK 414
PLN02271 PLN02271
serine hydroxymethyltransferase
 24-480 0e+00

serine hydroxymethyltransferase


Pssm-ID: 215153  Cd Length: 586  Bit Score: 565.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584  24 QPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFVDELEILCQKRALQV 103
Cdd:PLN02271  127 QPLPEADPDIHELMEKEKQRQFKGIELIASENFVCRAVMEALGSHLTNKYSEGMPGARYYTGNQYIDQIERLCCERALAA 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 104 YDLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTEK-KKISATSIFFESMPYKVNPETGYIN 182
Cdd:PLN02271  207 FGLDSEKWGVNVQPYSCTSANFAVYTGLLLPGDRIMGLDSPSGGHMSHGYYTPGgKKVSGASIFFESLPYKVNPQTGYID 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 183 YDQLEENARLFHPKLIIAGTSCYSRNLDYARLRRIADDNGAYLMADMAHISGLVAAGVVPSPFEHCHVVSTTTHKTLRGC 262
Cdd:PLN02271  287 YDKLEEKALDFRPKILICGGSSYPREWDYARFRQIADKCGAVLMCDMAHISGLVAAKECVNPFDYCDIVTSTTHKSLRGP 366

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 263 RAGMIFYRRGV----RSVDPKTGKEIL-YNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTPEFRIYQRQVVANSRA 337
Cdd:PLN02271  367 RGGIIFYRKGPklrkQGMLLSHGDDNShYDFEEKINFAVFPSLQGGPHNNHIAALAIALKQVATPEYKAYMQQVKKNAQA 446

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 338 LAATLMELGYTVVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDKSALRPSGLRLGTPALTSRGLLEKE 417
Cdd:PLN02271  447 LASALLRRKCRLVTGGTDNHLLLWDLTTLGLTGKNYEKVCEMCHITLNKTAIFGDNGTISPGGVRIGTPAMTSRGCLESD 526

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1823852584 418 FQKVAHFIHRGIELTLQLQSDVGaratlKEFKEKLAGDEKHRSaIRALREEVESFASLFPLPG 480
Cdd:PLN02271  527 FETIADFLLRAAQIASAVQREHG-----KLQKEFLKGLQNNKD-IVELRNRVEAFASQFAMPG 583
PRK13034 PRK13034
serine hydroxymethyltransferase; Reviewed
 22-479 0e+00

serine hydroxymethyltransferase; Reviewed


Pssm-ID: 237280  Cd Length: 416  Bit Score: 527.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584  22 MAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFVDELEILCQKRAL 101
Cdd:PRK13034    5 FSDSLEEYDDEVFAAINKELERQQDHLELIASENFTSPAVMEAQGSVLTNKYAEGYPGKRYYGGCEFVDEVEALAIERAK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 102 QVYdldpQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGfmtekKKISATSIFFESMPYKVNPETGYI 181
Cdd:PRK13034   85 QLF----GCDYANVQPHSGSQANGAVYLALLKPGDTILGMSLSHGGHLTHG-----AKVSLSGKWYNAVQYGVDRLTGLI 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 182 NYDQLEENARLFHPKLIIAGTSCYSRNLDYARLRRIADDNGAYLMADMAHISGLVAAGVVPSPFEHCHVVSTTTHKTLRG 261
Cdd:PRK13034  156 DYDEVEELAKEHKPKLIIAGFSAYPRELDFARFREIADEVGALLMVDMAHIAGLVAAGEHPNPFPHAHVVTTTTHKTLRG 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 262 CRAGMifyrrgvrsvdpktgkeILYNLESL---INSAVFPGLQGGPHNHAIAGVAVALKQAMTPEFRIYQRQVVANSRAL 338
Cdd:PRK13034  236 PRGGM-----------------ILTNDEEIakkINSAVFPGLQGGPLMHVIAAKAVAFGEALQPEFKTYAKQVIANAQAL 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 339 AATLMELGYTVVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGD-KSALRPSGLRLGTPALTSRGLLEKE 417
Cdd:PRK13034  299 AEVLKERGYDLVSGGTDNHLLLVDLRPKGLSGKDAEQALERAGITVNKNTVPGDtESPFVTSGIRIGTPAGTTRGFGEAE 378

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1823852584 418 FQKVAHFIhrgieltLQLQSDVGARATLKEfkeklagdekhrsairaLREEVESFASLFPLP 479
Cdd:PRK13034  379 FREIANWI-------LDVLDDLGNAALEQR-----------------VRKEVKALCSRFPIY 416
PRK13580 PRK13580
glycine hydroxymethyltransferase;
37-481 2.94e-125

glycine hydroxymethyltransferase;


Pssm-ID: 184161  Cd Length: 493  Bit Score: 373.99  E-value: 2.94e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584  37 IKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFVDELEILCQKRALQVYDLDPQCwgvnVQ 116
Cdd:PRK13580   41 IRQELADQRSSLKLIASENYSSLAVQLAMGNLLTDKYAEGTPGHRFYAGCQNVDTVEWEAAEHAKELFGAEHAY----VQ 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 117 PYSGSPANFAVYTAL---------VEPHG----------------------RIMGLDLPDGGHLTHGFmteKKKISatSI 165
Cdd:PRK13580  117 PHSGADANLVAFWAIlahkvespaLEKLGaktvndlteedwealraelgnqRLLGMSLDSGGHLTHGF---RPNIS--GK 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 166 FFESMPYKVNPETGYINYDQLEENARLFHPKLIIAGTSCYSRNLDYARLRRIADDNGAYLMADMAHISGLVAAGVVP--- 242
Cdd:PRK13580  192 MFHQRSYGVDPDTGLLDYDEIAALAREFKPLILVAGYSAYPRRVNFAKLREIADEVGAVLMVDMAHFAGLVAGKVFTgde 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 243 SPFEHCHVVSTTTHKTLRGCRAGMIFyrrgvrsvdpkTGKEilynLESLINSAVfPGLQGGPHNHAIAGVAVALKQAMTP 322
Cdd:PRK13580  272 DPVPHADIVTTTTHKTLRGPRGGLVL-----------AKKE----YADAVDKGC-PLVLGGPLPHVMAAKAVALAEARTP 335

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 323 EFRIYQRQVVANSRALAATLMELGYTVVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDKS-ALRPSGL 401
Cdd:PRK13580  336 EFQKYAQQVVDNARALAEGFLKRGARLVTGGTDNHLVLIDVTSFGLTGRQAESALLDAGIVTNRNSIPSDPNgAWYTSGI 415

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 402 RLGTPALTSRGLLEKEFQKVAHFIHRGIELTlqlqsDVGARATLKEFKEKLAGDEKHRSAIRAlreEVESFASLFPL-PG 480
Cdd:PRK13580  416 RLGTPALTTLGMGSDEMDEVAELIVKVLSNT-----TPGTTAEGAPSKAKYELDEGVAQEVRA---RVAELLARFPLyPE 487


                  .
gi 1823852584 481 L 481
Cdd:PRK13580  488 I 488
AAT_I cd01494
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 96-270 2.90e-33

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


Pssm-ID: 99742 [Multi-domain]  Cd Length: 170  Bit Score: 123.65  E-value: 2.90e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584  96 CQKRALQVYDldPQCWGVNVQPySGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHgfmtekkkiSATSIFFESMPYKVN 175
Cdd:cd01494     5 LEEKLARLLQ--PGNDKAVFVP-SGTGANEAALLALLGPGDEVIVDANGHGSRYWV---------AAELAGAKPVPVPVD 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 176 PETGY-INYDQLEENARLFHPKLIIAGTSCYSRNL--DYARLRRIADDNGAYLMADMAHISGLVAAGVVPSPFEHCHVVS 252
Cdd:cd01494    73 DAGYGgLDVAILEELKAKPNVALIVITPNTTSGGVlvPLKEIRKIAKEYGILLLVDAASAGGASPAPGVLIPEGGADVVT 152

                         170
                  ....*....|....*...
gi 1823852584 253 TTTHKTLRGCRAGMIFYR 270
Cdd:cd01494   153 FSLHKNLGGEGGGVVIVK 170
KBL_like cd06454
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ...
 119-397 6.05e-04

KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.


Pssm-ID: 99747 [Multi-domain]  Cd Length: 349  Bit Score: 41.78  E-value: 6.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 119 SGSPANFAVYTALVEPHGRImgldLPDggHLTHGFMTEKKKISATSIFfesmPYKVNpetgyiNYDQLEE---NARLFHP 195
Cdd:cd06454    69 SGYAANDGVLSTLAGKGDLI----ISD--SLNHASIIDGIRLSGAKKR----IFKHN------DMEDLEKllrEARRPYG 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 196 KLIIAGTSCYSRNLDYARLRRI---ADDNGAYLMADMAHISGLV---AAGVVPSPFEHCHV--VSTTTHKTLrGCRAGMI 267
Cdd:cd06454   133 KKLIVTEGVYSMDGDIAPLPELvdlAKKYGAILFVDEAHSVGVYgphGRGVEEFGGLTDDVdiIMGTLGKAF-GAVGGYI 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 268 FYRRGVRSVdpktgkeILYNLESLINSAVFPglqggPHNhaIAGVAVALKQAMT-PEFRIYQRqvvANSRALAATLMELG 346
Cdd:cd06454   212 AGSKELIDY-------LRSYARGFIFSTSLP-----PAV--AAAALAALEVLQGgPERRERLQ---ENVRYLRRGLKELG 274

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 347 YTVvtGGSDNHLILVDLrskgtdGGRAEKVLEACSI---------ACNKNTCPGDKSALR 397
Cdd:cd06454   275 FPV--GGSPSHIIPPLI------GDDPAKAVAFSDAllergiyvqAIRYPTVPRGTARLR 326
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
113-397 9.84e-04

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 41.14  E-value: 9.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 113 VNVQPYSGSPANFAVYTALVEPHGRIMGLDLPdgghlTHGFMTEKKKISAtsifFESMPYKVNPETGY-INYDQLEE--N 189
Cdd:pfam00155  64 AAVVFGSGAGANIEALIFLLANPGDAILVPAP-----TYASYIRIARLAG----GEVVRYPLYDSNDFhLDFDALEAalK 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 190 ARlfhPKLIIAgTSCYS---RNLDYARLRRIAD---DNGAYLMADMAHISGL--------VAAGVVPSPfeHCHVVSTTT 255
Cdd:pfam00155 135 EK---PKVVLH-TSPHNptgTVATLEELEKLLDlakEHNILLLVDEAYAGFVfgspdavaTRALLAEGP--NLLVVGSFS 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823852584 256 hKT--LRGCRAGMIFYRRGVRSvdpktgkeilyNLESLINSAVFPGlqggphnhaiAGVAVALKQAMTPEFRI-----YQ 328
Cdd:pfam00155 209 -KAfgLAGWRVGYILGNAAVIS-----------QLRKLARPFYSST----------HLQAAAAAALSDPLLVAseleeMR 266

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1823852584 329 RQVVANSRALAATLMELGYTVVtgGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDKSALR 397
Cdd:pfam00155 267 QRIKERRDYLRDGLQAAGLSVL--PSQAGFFLLTGLDPETAKELAQVLLEEVGVYVTPGSSPGVPGWLR 333
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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