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    POLY polyprotein;protein F [ Hepatitis C virus genotype 3 ]

    Gene ID: 11027185, updated on 18-Aug-2023

    Summary

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    Gene symbol
    POLY
    Gene description
    polyprotein;protein F
    Locus tag
    HCV3_gp1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Hepatitis C virus genotype 3 (subtype: 3a, isolate: NZL1, nat-host: Homo sapiens)
    Lineage
    Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes; Amarillovirales; Flaviviridae; Hepacivirus
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    Genomic context

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    Sequence:
    NC_009824.1 (340..9405)

    NC_009824.1Genomic Context describing neighboring genes

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009824.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel substitution in NS5A enhances the resistance of hepatitis C virus genotype 3 to daclatasvir. Fernandes Campos GR, et al. J Gen Virol, 2021 Jan. PMID 33141008, Free PMC Article
    2. Mutations in the NS5A gene are associated with response to interferon+ribavirin combination therapy in patients with chronic hepatitis C virus 3a infection. Ullah S, et al. Eur J Gastroenterol Hepatol, 2013 Oct. PMID 23611896
    3. Mutations in two PKR-binding domains in chronic hepatitis C of genotype 3a and correlation with viral loads and interferon responsiveness. Yokozaki S, et al. J Med Virol, 2011 Oct. PMID 21837788
    4. NS3 protease of genotype 3 subtype h HCV identified in southeastern France. Colson P, et al. Antivir Ther, 2011. PMID 21685551
    5. Positional effect of phosphorylation sites 266 and 267 in the cytoplasmic domain of the E2 protein of hepatitis C virus 3a genotype: interferon resistance analysis via sequence alignment. Rafique S, et al. Virol J, 2011 May 5. PMID 21545731, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The A150V Polymorphism of Genotype 3 Hepatitis C Virus Polymerase Inhibits Interferon Alfa by Suppressing Protein Kinase R Activation.
      Title: The A150V Polymorphism of Genotype 3 Hepatitis C Virus Polymerase Inhibits Interferon Alfa by Suppressing Protein Kinase R Activation.
    2. A novel substitution in NS5A enhances the resistance of hepatitis C virus genotype 3 to daclatasvir.
      Title: A novel substitution in NS5A enhances the resistance of hepatitis C virus genotype 3 to daclatasvir.
    3. Mutations in the NS5A gene are associated with response to interferon+ribavirin combination therapy in patients with chronic hepatitis C virus 3a infection.
      Title: Mutations in the NS5A gene are associated with response to interferon+ribavirin combination therapy in patients with chronic hepatitis C virus 3a infection.
    4. study shows NS5A-IFN sensitivity-determining region (ISDR) is significantly associated with HCV viral load suggesting that the ISDR plays an important role in regulating viral replication in patients infected with HCV genotype 3a
      Title: Mutations in two PKR-binding domains in chronic hepatitis C of genotype 3a and correlation with viral loads and interferon responsiveness.
    5. NS3 protease sequences of HCV-3h recovered in the present study harbour specific amino acid residues not encountered in other reference HCV genotypes and subtypes at nine of the 181 NS3 protease positions.
      Title: NS3 protease of genotype 3 subtype h HCV identified in southeastern France.
    6. A hybrid in-silico and wet laboratory approach of motif prediction, evolutionary and structural analysis has pointed out serine 266 and 267 of the hepatitis C virus E2 gene as a hopeful claimant for the serine phosphorylation.
      Title: Positional effect of phosphorylation sites 266 and 267 in the cytoplasmic domain of the E2 protein of hepatitis C virus 3a genotype: interferon resistance analysis via sequence alignment.
    Submit: New GeneRIF Correction

    General protein information

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    Preferred Names
    polyprotein;protein F
    Names
    core protein
    E1 protein
    E2 protein
    NS2 protein
    NS3 protease/helicase
    NS4A protein
    NS4B protein
    NS5A protein
    NS5B RNA-dependent RNA polymerase
    p7 protein
    YP_009272631.1
    • -2/+1 frameshift protein F; position predicted based on homology to protein F/predicted ribosomal slippage site in HCV1 RefSeq NC_004102.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_009824.1 Reference assembly

      Range
      340..9405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_001469631.1 polyprotein [Hepatitis C virus genotype 3]

      See identical proteins and their annotated locations for YP_001469631.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q81258
      UniProtKB/TrEMBL
      A0A076G8P8
      Conserved Domains (15) summary
      pfam01001
      Location:1734 → 1927
      HCV_NS4b; Hepatitis C virus non-structural protein NS4b
      pfam01539
      Location:193 → 382
      HCV_env; Hepatitis C virus envelope glycoprotein E1
      pfam01560
      Location:386 → 735
      HCV_NS1; Hepatitis C virus non-structural protein E2/NS1
      pfam01543
      Location:2 → 115
      HCV_capsid; Hepatitis C virus capsid protein
      pfam08301
      Location:2074 → 2174
      HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
      pfam01542
      Location:116 → 190
      HCV_core; Hepatitis C virus core protein
      pfam12941
      Location:2185 → 2430
      HCV_NS5a_C; HCV NS5a protein C-terminal region
      cl38915
      Location:1368 → 1492
      DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases
      pfam00998
      Location:2433 → 2944
      RdRP_3; Viral RNA dependent RNA polymerase
      pfam01006
      Location:1664 → 1717
      HCV_NS4a; Hepatitis C virus non-structural protein NS4a
      pfam01506
      Location:1982 → 2002
      HCV_NS5a; Hepatitis C virus non-structural 5a protein membrane anchor
      pfam01538
      Location:818 → 1011
      HCV_NS2; Hepatitis C virus non-structural protein NS2
      pfam02907
      Location:1062 → 1210
      Peptidase_S29; Hepatitis C virus NS3 protease
      pfam08300
      Location:2012 → 2073
      HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain
      cl28899
      Location:1230 → 1372
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    2. YP_001491549.1 core protein

      Conserved Domains (2) summary
      pfam01543
      Location:2 → 115
      HCV_capsid; Hepatitis C virus capsid protein
      pfam01542
      Location:116 → 190
      HCV_core; Hepatitis C virus core protein

    3. YP_001491550.1 E1 protein

      Conserved Domains (1) summary
      pfam01539
      Location:2 → 191
      HCV_env; Hepatitis C virus envelope glycoprotein E1

    4. YP_001491551.1 E2 protein

      Conserved Domains (1) summary
      pfam01560
      Location:3 → 352
      HCV_NS1; Hepatitis C virus non-structural protein E2/NS1

    5. YP_001491552.1 NS2 protein

      Conserved Domains (1) summary
      pfam01538
      Location:83 → 276
      HCV_NS2; Hepatitis C virus non-structural protein NS2

    6. YP_001491553.1 NS3 protease/helicase

      Conserved Domains (4) summary
      pfam02907
      Location:50 → 198
      Peptidase_S29; Hepatitis C virus NS3 protease
      smart00487
      Location:211 → 349
      DEXDc; DEAD-like helicases superfamily
      cd00046
      Location:218 → 345
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:372 → 449
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

    7. YP_001491554.1 NS4A protein

      Conserved Domains (1) summary
      pfam01006
      Location:1 → 54
      HCV_NS4a; Hepatitis C virus non-structural protein NS4a

    8. YP_001491555.1 NS4B protein

      Conserved Domains (1) summary
      pfam01001
      Location:17 → 210
      HCV_NS4b; Hepatitis C virus non-structural protein NS4b

    9. YP_001491556.1 NS5A protein

      Conserved Domains (4) summary
      pfam08301
      Location:96 → 196
      HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
      pfam01506
      Location:4 → 24
      HCV_NS5a; Hepatitis C virus non-structural 5a protein membrane anchor
      pfam08300
      Location:34 → 95
      HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain
      pfam12941
      Location:207 → 452
      HCV_NS5a_C; HCV NS5a protein C-terminal region

    10. YP_001491557.1 NS5B RNA-dependent RNA polymerase

      Conserved Domains (1) summary
      pfam00998
      Location:3 → 514
      RdRP_3; Viral RNA dependent RNA polymerase

    11. YP_009272632.1 p7 protein

    12. YP_009272631.1 protein F [Hepatitis C virus genotype 3]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7U3NU65, A0A7U3NUI4
    Protein Accession Links
    GenPept Link UniProtKB Link
    BAA04609.1

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