CRTC3 CREB regulated transcription coactivator 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CRTC3provided by HGNC
Official Full Name: CREB regulated transcription coactivator 3provided by HGNC
Primary source: HGNC:HGNC:26148
See related: Ensembl:ENSG00000140577 MIM:608986; AllianceGenome:HGNC:26148
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TORC3; TORC-3
Summary: This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Expression: Ubiquitous expression in ovary (RPKM 20.6), fat (RPKM 11.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q26.1

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (90529923..90645345)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (88285952..88401360)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (91073155..91188577)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Morphological and biological properties of silica nanoparticles for CRTC3-siRNA delivery and downregulation of the RGS2 expression in preadipocytes.
Title: Morphological and biological properties of silica nanoparticles for CRTC3-siRNA delivery and downregulation of the RGS2 expression in preadipocytes.
TORC2/3-mediated DUSP1 upregulation is essential for human decidualization.
Title: TORC2/3-mediated DUSP1 upregulation is essential for human decidualization.
Colorectal cancer risk variants rs10161980 and rs7495132 are associated with cancer survival outcome by a recessive mode of inheritance.
Title: Colorectal cancer risk variants rs10161980 and rs7495132 are associated with cancer survival outcome by a recessive mode of inheritance.
Pancreatic mucoepidermoid carcinoma does not have CRTC1/3-MAML2 fusion gene and MAML2 gene rearrangement.
Title: "Pancreatic Mucoepidermoid Carcinoma" Is not a Pancreatic Counterpart of CRTC1/3-MAML2 Fusion Gene-related Mucoepidermoid Carcinoma of the Salivary Gland, and May More Appropriately be Termed Pancreatic Adenosquamous Carcinoma With Mucoepidermoid Carcinoma-like Features.
CRTC3-MAML2 gene fusion occurs in hidradenomas.
Title: A novel fusion gene CRTC3-MAML2 in hidradenoma: histopathological significance.
CRTC3 polymorphism was associated with the onset of acute coronary syndrome in Han Chinese patients, which may be related to the imbalance of the lipid metabolism
Title: Cyclic adenosine monophosphate-regulated transcriptional co-activator 3 polymorphism in Chinese patients with acute coronary syndrome.
findings suggest further characterization of MECs is needed before considering the CRTC1/3-MAML2 gene fusion as a prognostic biomarker
Title: Correlation of Crtc1/3-Maml2 fusion status, grade and survival in mucoepidermoid carcinoma.
revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions in cutaneous hidradenoma
Title: Cutaneous hidradenoma: a study of 21 neoplasms revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions.
The CRTC3 polymorphism rs3862434 is associated with the plasma level of total cholesterol, and rs11635252 is associated with the risks of overweight and hypertriglyceridemia in a Chinese Han population.
Title: CRTC3 polymorphisms were associated with the plasma level of total cholesterol and the risks of overweight and hypertriglyceridemia in a Chinese Han population.
Metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands did not harbor CRTC1-MAML2 and CRTC3-MAML2 fusion transcripts, respectively, or MAML2 gene rearrangement.
Title: CRTC1-MAML2 and CRTC3-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Whole genome association scan for genetic polymorphisms influencing information processing speed. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of CREB regulated transcription coactivator 3 (CRTC3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D15S1476E (e-PCR)
- UniSTS:474425

SHGC-37377 (e-PCR)
- UniSTS:34381

SHGC-32525 (e-PCR)
- UniSTS:36954

NoName (e-PCR)
- UniSTS:481946

NoName (e-PCR)
- UniSTS:486301

RH91249 (e-PCR)
- UniSTS:91568

PMC311040P16 (e-PCR)
- UniSTS:272853

D15S1153 (e-PCR)
- UniSTS:154586

D15S1159 (e-PCR)
- UniSTS:154592

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cAMP response element binding protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to cAMP	IBA Inferred from Biological aspect of Ancestor more info
involved_in energy homeostasis	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in macrophage activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of CREB transcription factor activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CREB-regulated transcription coactivator 3

Names: transducer of regulated CREB protein 3; transducer of regulated cAMP response element-binding protein (CREB) 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_047180.1 RefSeqGene

Range

5038..120460

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001042574.3 → NP_001036039.1 CREB-regulated transcription coactivator 3 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' terminal exon compared to variant 1. It encodes isoform b which is shorter than isoform a.

Source sequence(s)

AI969212, AK025521, AK074170, AL360259, AY360173, BP238198, BP365179, DB288138, HY057135, HY109267

Consensus CDS

CCDS45348.1

UniProtKB/TrEMBL

Q8TEF4

Related

ENSP00000416573.2, ENST00000420329.6

Conserved Domains (4) summary

PHA03378
Location:346 → 537

PHA03378; EBNA-3B; Provisional

pfam12884
Location:11 → 64

TORC_N; Transducer of regulated CREB activity, N-terminus

pfam12885
Location:159 → 319

TORC_M; Transducer of regulated CREB activity middle domain

pfam12886
Location:545 → 618

TORC_C; Transducer of regulated CREB activity, C-terminus
NM_022769.5 → NP_073606.3 CREB-regulated transcription coactivator 3 isoform a

See identical proteins and their annotated locations for NP_073606.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AC021422, AI969212, AK074170, AL360259, AY360173, BP238198, BP365179, CN298837, DB288138, HY057135, HY109267

Consensus CDS

CCDS32331.1

UniProtKB/Swiss-Prot

Q6DK61, Q6DK62, Q6UUV7, Q8NF38, Q9H6U2

UniProtKB/TrEMBL

Q8TEF4

Related

ENSP00000268184.6, ENST00000268184.11

Conserved Domains (4) summary

PHA03378
Location:346 → 537

PHA03378; EBNA-3B; Provisional

pfam12884
Location:11 → 64

TORC_N; Transducer of regulated CREB activity, N-terminus

pfam12885
Location:159 → 319

TORC_M; Transducer of regulated CREB activity middle domain

pfam12886
Location:545 → 619

TORC_C; Transducer of regulated CREB activity, C-terminus