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    IL6R interleukin 6 receptor [ Homo sapiens (human) ]

    Gene ID: 3570, updated on 2-Nov-2024

    Summary

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    Official Symbol
    IL6Rprovided by HGNC
    Official Full Name
    interleukin 6 receptorprovided by HGNC
    Primary source
    HGNC:HGNC:6019
    See related
    Ensembl:ENSG00000160712 MIM:147880; AllianceGenome:HGNC:6019
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IL6Q; gp80; CD126; HIES5; IL-6R; IL6RA; IL6RQ; IL-1Ra; IL-6RA; IL6QTL; IL-6R-1
    Summary
    This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been identified in this gene. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, Aug 2020]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
    Expression
    Ubiquitous expression in appendix (RPKM 12.7), lymph node (RPKM 12.1) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IL6R in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (154405343..154469450)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (153542427..153606601)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154377819..154441926)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATPase phospholipid transporting 8B2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154320806-154321790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154321791-154322774 Neighboring gene RNA, U7 small nuclear 57 pseudogene Neighboring gene MPRA-validated peak417 silencer Neighboring gene MPRA-validated peak418 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1778 Neighboring gene mitochondrial ribosomal protein S33 pseudogene 1 Neighboring gene ribosomal protein SA pseudogene 17 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1356 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1357 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154378343-154378949 Neighboring gene IL6R antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154390689-154391202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154399170-154399670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154399671-154400171 Neighboring gene proteasome 26S subunit, non-ATPase, 8 pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154404493-154405326 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154405327-154406158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154406159-154406992 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154417761-154418260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154437441-154437942 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154461067-154461569 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154461570-154462071 Neighboring gene Src homology 2 domain containing E Neighboring gene tudor domain containing 10 Neighboring gene Sharpr-MPRA regulatory region 5559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1779 Neighboring gene UBE2Q1 antisense RNA 1 Neighboring gene ubiquitin conjugating enzyme E2 Q1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Influence of IL6R gene polymorphisms in the effectiveness to treatment with tocilizumab in rheumatoid arthritis. Maldonado-Montoro M, et al. Pharmacogenomics J, 2018 Jan. PMID 27958380
    2. Interleukin 6 receptor (IL-6R) was an independent prognostic factor in cervical cancer. Luan S, et al. Histol Histopathol, 2018 Mar. PMID 28741286
    3. Increased copy number of the interleukin-6 receptor gene is associated with adverse survival in multiple myeloma patients treated with autologous stem cell transplantation. Kim SY, et al. Biol Blood Marrow Transplant, 2011 Jun. PMID 21220034
    4. Circulating Soluble IL-6 Receptor Concentration and Visceral Adipocyte Size Are Related to Insulin Resistance in Taiwanese Adults with Morbid Obesity. Kuo FC, et al. Metab Syndr Relat Disord, 2017 May. PMID 28346858
    5. Neutrophil-mediated IL-6 receptor trans-signaling and the risk of chronic obstructive pulmonary disease and asthma. Farahi N, et al. Hum Mol Genet, 2017 Apr 15. PMID 28334838, Free PMC Article

    See all (504) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IL-6R (trans-signaling) is a key regulator of reverse cholesterol transport in lipid-laden macrophages.
      Title: IL-6R (trans-signaling) is a key regulator of reverse cholesterol transport in lipid-laden macrophages.
    2. Genetic variations of IL10 and IL6R genes in acute anterior uveitis in Han Chinese.
      Title: Genetic variations of IL10 and IL6R genes in acute anterior uveitis in Han Chinese.
    3. Causal relationship of interleukin-6 and its receptor on sarcopenia traits using mendelian randomization.
      Title: Causal relationship of interleukin-6 and its receptor on sarcopenia traits using mendelian randomization.
    4. The Possible Association of IL-6R Gene Polymorphisms in the Development of Diabetic Nephropathy.
      Title: The Possible Association of IL-6R Gene Polymorphisms in the Development of Diabetic Nephropathy.
    5. No Association of Polymorphisms in the Genes Encoding Interleukin-6 and Interleukin-6 Receptor Subunit Alpha with the Risk of Keloids in Polish Patients.
      Title: No Association of Polymorphisms in the Genes Encoding Interleukin-6 and Interleukin-6 Receptor Subunit Alpha with the Risk of Keloids in Polish Patients.
    6. Heterogeneous associations between interleukin-6 receptor variants and phenotypes across ancestries and implications for therapy.
      Title: Heterogeneous associations between interleukin-6 receptor variants and phenotypes across ancestries and implications for therapy.
    7. Role of interleukin-6 and endothelin-1 receptors in enhanced melanocyte dendricity of facial spots and suppression of their ligands by niacinamide and tranexamic acid.
      Title: Role of interleukin-6 and endothelin-1 receptors in enhanced melanocyte dendricity of facial spots and suppression of their ligands by niacinamide and tranexamic acid.
    8. Associations between serum estradiol and IL-6/sIL-6R/sgp130 complex in female patients with major depressive disorder.
      Title: Associations between serum estradiol and IL-6/sIL-6R/sgp130 complex in female patients with major depressive disorder.
    9. Role of interleukin 6 and its soluble receptor on the diffusion barrier dysfunction of alveolar tissue.
      Title: Role of interleukin 6 and its soluble receptor on the diffusion barrier dysfunction of alveolar tissue.
    10. Possible Role of IL-6R/STAT3/MiRNA-34a Feedback Loop in Osteosarcoma.
      Title: Possible Role of IL-6R/STAT3/MiRNA-34a Feedback Loop in Osteosarcoma.
    Submit: New GeneRIF Correction See all GeneRIFs (393)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.
    EBI GWAS Catalog
    A genome-wide association study identifies protein quantitative trait loci (pQTLs).
    EBI GWAS Catalog
    Framingham Heart Study genome-wide association: results for pulmonary function measures.
    EBI GWAS Catalog
    Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.
    EBI GWAS Catalog
    Genetics of rheumatoid arthritis contributes to biology and drug discovery.
    EBI GWAS Catalog
    Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.
    EBI GWAS Catalog
    Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
    EBI GWAS Catalog
    Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.
    EBI GWAS Catalog
    Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
    EBI GWAS Catalog
    Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
    EBI GWAS Catalog
    Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 infected clinical samples have plasma extracellular vesicles that contain elevated CCL1 (I309), IGFBP1, CCL5 (RANTES), GMCSF, ANG, ADIPOQ (ACRP30), CSF3 (GCSF), CXCL1 (GRO), ICAM1, IL2RA, IL6R, TNFRSF1A, and TIMP1 when compared to healthy donors PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of interleukin 6 receptor (IL6R) in human B cells PubMed
    Envelope surface glycoprotein gp160, precursor env Antibodies against cell surface molecules LFA-1, ICAM-1, HLA-DR, and CD28 inhibit the HIV-1 gp160-induced B cell differentiation response; gp160 also induces IL-6R and CD23 molecule expression on B cells PubMed
    Tat tat Ectopic expression of HIV-1 Tat induces the production of human IL-6 (huIL-6) and its receptor (huIL-6Ra) and activates STAT3 signaling; these effects are involved in Tat-mediated activation of Kaposi's sarcoma-associated herpes virus (KSHV) replication PubMed
    tat IL-6 and IL-6 receptor are upregulated in human epithelial cells by HIV-1 Tat treatment PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC104991

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ciliary neurotrophic factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to ciliary neurotrophic factor receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cytokine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables interleukin-11 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-11 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-6 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-6 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to interleukin-6 receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to interleukin-6 receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T-helper 17 cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in T-helper 17 cell lineage commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in acute-phase response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway via STAT IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ciliary neurotrophic factor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in endocrine pancreas development IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in endocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in extrinsic apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in hepatic immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in interleukin-11-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in interleukin-6-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interleukin-6-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in interleukin-6-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in interleukin-6-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in monocyte chemotaxis IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in negative regulation of collagen biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-8 production NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in neutrophil mediated immunity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of chemokine production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of glomerular mesangial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of leukocyte chemotaxis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of osteoblast differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of positive regulation of platelet aggregation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to cytokine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ciliary neurotrophic factor receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of interleukin-6 receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-6 receptor subunit alpha
    Names
    CD126 antigen
    IL-6 receptor subunit alpha
    membrane glycoprotein 80

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012087.1 RefSeqGene

      Range
      5151..69258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000565.4 → NP_000556.1  interleukin-6 receptor subunit alpha isoform 1 precursor

      See identical proteins and their annotated locations for NP_000556.1

      Status: REVIEWED

      Source sequence(s)
      AA035377, AL162591, BC132684, X12830
      Consensus CDS
      CCDS1067.1
      UniProtKB/Swiss-Prot
      A8KAE8, B2R6V4, P08887, Q16202, Q53EQ7, Q5FWG2, Q5VZ23
      UniProtKB/TrEMBL
      A0N0L5
      Related
      ENSP00000357470.3, ENST00000368485.8
      Conserved Domains (3) summary
      smart00408
      Location:39 → 97
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:216 → 308
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam09240
      Location:118 → 213
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    2. NM_001206866.2 → NP_001193795.1  interleukin-6 receptor subunit alpha isoform 3 precursor

      See identical proteins and their annotated locations for NP_001193795.1

      Status: REVIEWED

      Source sequence(s)
      AL162591
      Consensus CDS
      CCDS72927.1
      UniProtKB/TrEMBL
      A0A087WTB5
      Related
      ENSP00000477739.1, ENST00000622330.5
      Conserved Domains (3) summary
      cd00063
      Location:216 → 308
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam09240
      Location:118 → 213
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      cd20939
      Location:34 → 110
      IgC2_D1_IL-6RA; Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126); member of the C2-set of IgSF domains

    3. NM_001382769.1 → NP_001369698.1  interleukin-6 receptor subunit alpha isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162591
      Conserved Domains (3) summary
      cd00063
      Location:216 → 308
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam09240
      Location:118 → 213
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      cd20939
      Location:34 → 110
      IgC2_D1_IL-6RA; Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126); member of the C2-set of IgSF domains

    4. NM_001382770.1 → NP_001369699.1  interleukin-6 receptor subunit alpha isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162591
      Conserved Domains (3) summary
      cd00063
      Location:216 → 308
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam09240
      Location:118 → 213
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      cd20939
      Location:34 → 110
      IgC2_D1_IL-6RA; Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126); member of the C2-set of IgSF domains

    5. NM_001382771.1 → NP_001369700.1  interleukin-6 receptor subunit alpha isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162591
      Conserved Domains (3) summary
      cd00063
      Location:216 → 308
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam09240
      Location:118 → 213
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      cd20939
      Location:34 → 110
      IgC2_D1_IL-6RA; Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126); member of the C2-set of IgSF domains

    6. NM_001382772.1 → NP_001369701.1  interleukin-6 receptor subunit alpha isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162591
      Conserved Domains (3) summary
      cd00063
      Location:216 → 306
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam09240
      Location:118 → 213
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      cd20939
      Location:34 → 110
      IgC2_D1_IL-6RA; Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126); member of the C2-set of IgSF domains

    7. NM_001382773.1 → NP_001369702.1  interleukin-6 receptor subunit alpha isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162591
      Conserved Domains (3) summary
      cd00063
      Location:216 → 308
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam09240
      Location:118 → 213
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      cd20939
      Location:34 → 110
      IgC2_D1_IL-6RA; Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126); member of the C2-set of IgSF domains

    8. NM_001382774.1 → NP_001369703.1  interleukin-6 receptor subunit alpha isoform 9 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162591
      Conserved Domains (2) summary
      cd00063
      Location:96 → 188
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:40 → 93
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    9. NM_181359.3 → NP_852004.1  interleukin-6 receptor subunit alpha isoform 2 precursor

      See identical proteins and their annotated locations for NP_852004.1

      Status: REVIEWED

      Source sequence(s)
      AA035377, AL162591, BC089410
      Consensus CDS
      CCDS1068.1
      UniProtKB/Swiss-Prot
      P08887
      Related
      ENSP00000340589.4, ENST00000344086.8
      Conserved Domains (3) summary
      smart00408
      Location:39 → 97
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:216 → 308
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam09240
      Location:118 → 213
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      154405343..154469450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001199.2 → XP_016856688.1  interleukin-6 receptor subunit alpha isoform X1

    2. XM_047419655.1 → XP_047275611.1  interleukin-6 receptor subunit alpha isoform X6

    3. XM_005245139.2 → XP_005245196.1  interleukin-6 receptor subunit alpha isoform X8

      Conserved Domains (4) summary
      smart00408
      Location:39 → 97
      IGc2; Immunoglobulin C-2 Type
      smart00060
      Location:216 → 277
      FN3; Fibronectin type 3 domain
      smart00410
      Location:33 → 110
      IG_like; Immunoglobulin like
      pfam09240
      Location:118 → 213
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    4. XM_047419654.1 → XP_047275610.1  interleukin-6 receptor subunit alpha isoform X5

    5. XM_047419657.1 → XP_047275613.1  interleukin-6 receptor subunit alpha isoform X9

    6. XM_047419656.1 → XP_047275612.1  interleukin-6 receptor subunit alpha isoform X7

    7. XM_047419648.1 → XP_047275604.1  interleukin-6 receptor subunit alpha isoform X2

    8. XM_047419649.1 → XP_047275605.1  interleukin-6 receptor subunit alpha isoform X3

    9. XM_047419650.1 → XP_047275606.1  interleukin-6 receptor subunit alpha isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      153542427..153606601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336391.1 → XP_054192366.1  interleukin-6 receptor subunit alpha isoform X1

    2. XM_054336401.1 → XP_054192376.1  interleukin-6 receptor subunit alpha isoform X6

    3. XM_054336405.1 → XP_054192380.1  interleukin-6 receptor subunit alpha isoform X8

    4. XM_054336403.1 → XP_054192378.1  interleukin-6 receptor subunit alpha isoform X7

    5. XM_054336393.1 → XP_054192368.1  interleukin-6 receptor subunit alpha isoform X2

    6. XM_054336395.1 → XP_054192370.1  interleukin-6 receptor subunit alpha isoform X3

    7. XM_054336397.1 → XP_054192372.1  interleukin-6 receptor subunit alpha isoform X4

    8. XM_054336398.1 → XP_054192373.1  interleukin-6 receptor subunit alpha isoform X14

    9. XM_054336402.1 → XP_054192377.1  interleukin-6 receptor subunit alpha isoform X17

    10. XM_054336390.1 → XP_054192365.1  interleukin-6 receptor subunit alpha isoform X10

    11. XM_054336399.1 → XP_054192374.1  interleukin-6 receptor subunit alpha isoform X15

    12. XM_054336400.1 → XP_054192375.1  interleukin-6 receptor subunit alpha isoform X16

    13. XM_054336406.1 → XP_054192381.1  interleukin-6 receptor subunit alpha isoform X19

    14. XM_054336392.1 → XP_054192367.1  interleukin-6 receptor subunit alpha isoform X11

    15. XM_054336404.1 → XP_054192379.1  interleukin-6 receptor subunit alpha isoform X18

    16. XM_054336394.1 → XP_054192369.1  interleukin-6 receptor subunit alpha isoform X12

    17. XM_054336396.1 → XP_054192371.1  interleukin-6 receptor subunit alpha isoform X13

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08887.1 GenPept UniProtKB/Swiss-Prot:P08887

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