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Conserved domains on  [gi|1843978505|ref|NP_001369703|]
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interleukin-6 receptor subunit alpha isoform 9 precursor [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10414115)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 40-93 8.78e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09240:

Pssm-ID: 473895  Cd Length: 96  Bit Score: 55.11  E-value: 8.78e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1843978505  40 GDSEPCQYSQES--QKFSCQLAVPEGDSS-FYIVSMCV--ASSVGSKFSKTQTFQGCGI 93
Cdd:pfam09240  38 GPVLQCQYYIRDdgTRIGCQFDDLEGLSSsFHQVYICVngSSSAGPIRSSDQTFQLQNI 96
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 96-188 2.51e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 2.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978505  96 PDPPANITVTAVarNPRWLSVTWQDPHSWNSSFyrLRFELRYRAERSKTFTTWMVKDL-QHHCVIHDAWSGLRHVVQLRA 174
Cdd:cd00063     1 PSPPTNLRVTDV--TSTSVTLSWTPPEDDGGPI--TGYVVEYREKGSGDWKEVEVTPGsETSYTLTGLKPGTEYEFRVRA 76

                          90
                  ....*....|....
gi 1843978505 175 QEEFGQGEWSEWSP 188
Cdd:cd00063    77 VNGGGESPPSESVT 90
 
Name Accession Description Interval E-value
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 40-93 8.78e-10

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 55.11  E-value: 8.78e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1843978505  40 GDSEPCQYSQES--QKFSCQLAVPEGDSS-FYIVSMCV--ASSVGSKFSKTQTFQGCGI 93
Cdd:pfam09240  38 GPVLQCQYYIRDdgTRIGCQFDDLEGLSSsFHQVYICVngSSSAGPIRSSDQTFQLQNI 96
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 96-188 2.51e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 2.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978505  96 PDPPANITVTAVarNPRWLSVTWQDPHSWNSSFyrLRFELRYRAERSKTFTTWMVKDL-QHHCVIHDAWSGLRHVVQLRA 174
Cdd:cd00063     1 PSPPTNLRVTDV--TSTSVTLSWTPPEDDGGPI--TGYVVEYREKGSGDWKEVEVTPGsETSYTLTGLKPGTEYEFRVRA 76

                          90
                  ....*....|....
gi 1843978505 175 QEEFGQGEWSEWSP 188
Cdd:cd00063    77 VNGGGESPPSESVT 90
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 96-181 1.44e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 1.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978505   96 PDPPANITVTAVarNPRWLSVTWQDPHSWNSSFYRLRFELRYRaERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQ 175
Cdd:smart00060   1 PSPPSNLRVTDV--TSTSVTLSWEPPPDDGITGYIVGYRVEYR-EEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                   ....*.
gi 1843978505  176 EEFGQG 181
Cdd:smart00060  78 NGAGEG 83
 
Name Accession Description Interval E-value
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 40-93 8.78e-10

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 55.11  E-value: 8.78e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1843978505  40 GDSEPCQYSQES--QKFSCQLAVPEGDSS-FYIVSMCV--ASSVGSKFSKTQTFQGCGI 93
Cdd:pfam09240  38 GPVLQCQYYIRDdgTRIGCQFDDLEGLSSsFHQVYICVngSSSAGPIRSSDQTFQLQNI 96
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 96-188 2.51e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 2.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978505  96 PDPPANITVTAVarNPRWLSVTWQDPHSWNSSFyrLRFELRYRAERSKTFTTWMVKDL-QHHCVIHDAWSGLRHVVQLRA 174
Cdd:cd00063     1 PSPPTNLRVTDV--TSTSVTLSWTPPEDDGGPI--TGYVVEYREKGSGDWKEVEVTPGsETSYTLTGLKPGTEYEFRVRA 76

                          90
                  ....*....|....
gi 1843978505 175 QEEFGQGEWSEWSP 188
Cdd:cd00063    77 VNGGGESPPSESVT 90
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 96-181 1.44e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 1.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978505   96 PDPPANITVTAVarNPRWLSVTWQDPHSWNSSFYRLRFELRYRaERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQ 175
Cdd:smart00060   1 PSPPSNLRVTDV--TSTSVTLSWEPPPDDGITGYIVGYRVEYR-EEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                   ....*.
gi 1843978505  176 EEFGQG 181
Cdd:smart00060  78 NGAGEG 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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