Bone morphogenetic protein 4 and forskolin effect on embryonic AGM VE-cadherin+ cells
Summary:
Analysis of vascular endothelial (VE)-cadherin+ cells isolated from aorta-gonad-mesonephros (AGM) region of E11.5 embryos then treated with bone morphogenetic protein (BMP) 4, adenylyl cyclase activator forskolin, or both. Results provide insight into the role of BMP signaling in AGM hematopoiesis.
Kim PG, Nakano H, Das PP, Chen MJ et al. Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence. J Exp Med 2015 May 4;212(5):633-48. PMID: 25870201
