Mitochondrial complex I inhibitor rotenone effect on primary cortical neurons: time course
Summary:
Analysis of cortical neurons treated with 10nM rotenone for 8, 15, and 24hrs. Rotenone is a classical, high affinity inhibitor of mitochondrial complex I. Results provide insight into temporal molecular events underlying rotenone-mediated cortical neuronal death.
Yap YW, Chen MJ, Peng ZF, Manikandan J et al. Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling. Neurochem Int 2013 Apr;62(5):653-63. PMID: 23186747
