SMRT depleted breast cancer cell line response to estradiol: time course
Summary:
Analysis of ER-alpha+ MCF7 breast cancer cells depleted for the silencing mediator of retinoic acid and thyroid hormone receptor (SMRT). SMRT depleted cells examined 4 and 24 hours following treatment with estradiol. Results provide insight into the role of SMRT in breast cancer progression.
GPL6244:
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Citation:
Blackmore JK, Karmakar S, Gu G, Chaubal V et al. The SMRT coregulator enhances growth of estrogen receptor-α-positive breast cancer cells by promotion of cell cycle progression and inhibition of apoptosis. Endocrinology 2014 Sep;155(9):3251-61. PMID: 24971610
