H3K9me2 methyltransferase G9a depletion effect on breast cancer cell line
Summary:
Analysis of MDA-MB231 breast cancer cells depleted for G9a, a methyltransferase that mediates histone H3 lysine-9 di-methylation (H3K9me2). G9a depletion inhibits migratory ability and invasiveness of MDA-MB231 cells. Results provide insight into role of G9a and H3K9me2 in breast cancer progression.
GPL6244:
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Citations:
Dong C, Wu Y, Yao J, Wang Y et al. G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer. J Clin Invest 2012 Apr;122(4):1469-86. PMID: 22406531
Dong C, Yuan T, Wu Y, Wang Y et al. Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell 2013 Mar 18;23(3):316-31. PMID: 23453623
