Parkin expression in parkin-deficient U87MG glioma cells
Summary:
Analysis of U87MG glioma cells stably expressing parkin or vector alone. Parkin expression is dramatically reduced in glioma cells. Parkin mutations are a major cause of parkinsonism. Results provide insight into tumor suppressor function of parkin in brain tumors.
GPL6244:
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Citation:
Yeo CW, Ng FS, Chai C, Tan JM et al. Parkin pathway activation mitigates glioma cell proliferation and predicts patient survival. Cancer Res 2012 May 15;72(10):2543-53. PMID: 22431710
